IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study

Interferon lambda 3 (IFNL3, previously called IL-28B) is a cytokine with effects against viral and bacterial pathogens. We aimed to analyze the IFNL3 rs12980275 SNP in patients who underwent major surgery, in order to establish its relationship with susceptibility to septic shock and septic shock-re...

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Autores: Perez-Garcia, Felipe, Soria, Susana, Jorge-Monjas, Pablo, Gómez-Sánchez, Esther, Heredia-Rodríguez, María, Gómez-Pesquera, Estefanía, Martínez-Paz, Pedro, Tamayo, Eduardo, Resino, Salvador, Fernandez-Rodriguez, Amanda, Jimenez-Sousa, Maria Angeles
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/10878
Acceso en línea:http://hdl.handle.net/20.500.12105/10878
Access Level:acceso abierto
Palabra clave:IFNL3
SNP
Major surgery
rs12980275
Sepsis
septic shock
Survival
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spelling IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective StudyPerez-Garcia, FelipeSoria, SusanaJorge-Monjas, PabloGómez-Sánchez, EstherHeredia-Rodríguez, MaríaGómez-Pesquera, EstefaníaMartínez-Paz, PedroTamayo, EduardoResino, SalvadorFernandez-Rodriguez, AmandaJimenez-Sousa, Maria AngelesIFNL3SNPMajor surgeryrs12980275Sepsisseptic shockSurvivalInterferon lambda 3 (IFNL3, previously called IL-28B) is a cytokine with effects against viral and bacterial pathogens. We aimed to analyze the IFNL3 rs12980275 SNP in patients who underwent major surgery, in order to establish its relationship with susceptibility to septic shock and septic shock-related death in these patients. We performed a case-control study on 376 patients to establish the association between IFNL3 rs12980275 SNP and the susceptibility to develop septic shock. Besides, we performed a longitudinal study among 172 septic shock patients using survival analysis with one censoring point of 28-days mortality. The IFNL3 rs12980275 polymorphism was genotyped by Agena Bioscience's MassARRAY platform. IFNL3 rs12980275 polymorphism was not associated with higher susceptibility to infection and septic shock development. Regarding survival analysis, the Kaplan-Meier analysis showed that patients with IFNL3 rs12980275 AA genotype had higher survival than patients with GG genotype (p = 0.003). The Cox regression analysis adjusted by the most relevant clinical and epidemiological characteristics showed that the GG genotype (recessive model) and the presence of the G allele (additive model) were associated with higher risk of death [adjusted hazard ratio (aHR) = 2.15, p = 0.034; aHR = 1.50, p = 0.030, respectively]. In conclusion, IFNL3 rs12980275 polymorphism was associated with septic shock-related death in patients who underwent major surgery. The A allele was linked to protection, and the G allele was associated with an increased risk of death. This is a first preliminary study that suggests for the first time a role of IFNL3 polymorphisms in the prognosis of septic shock.Frontiers MediaInstituto de Salud Carlos IIIPfizerJunta de Castilla y León (España)20202020-08-1020202020-01-0120202020-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/10878reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/108782026-06-12T12:43:37Z
dc.title.none.fl_str_mv IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study
title IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study
spellingShingle IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study
Perez-Garcia, Felipe
IFNL3
SNP
Major surgery
rs12980275
Sepsis
septic shock
Survival
title_short IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study
title_full IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study
title_fullStr IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study
title_full_unstemmed IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study
title_sort IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study
dc.creator.none.fl_str_mv Perez-Garcia, Felipe
Soria, Susana
Jorge-Monjas, Pablo
Gómez-Sánchez, Esther
Heredia-Rodríguez, María
Gómez-Pesquera, Estefanía
Martínez-Paz, Pedro
Tamayo, Eduardo
Resino, Salvador
Fernandez-Rodriguez, Amanda
Jimenez-Sousa, Maria Angeles
author Perez-Garcia, Felipe
author_facet Perez-Garcia, Felipe
Soria, Susana
Jorge-Monjas, Pablo
Gómez-Sánchez, Esther
Heredia-Rodríguez, María
Gómez-Pesquera, Estefanía
Martínez-Paz, Pedro
Tamayo, Eduardo
Resino, Salvador
Fernandez-Rodriguez, Amanda
Jimenez-Sousa, Maria Angeles
author_role author
author2 Soria, Susana
Jorge-Monjas, Pablo
Gómez-Sánchez, Esther
Heredia-Rodríguez, María
Gómez-Pesquera, Estefanía
Martínez-Paz, Pedro
Tamayo, Eduardo
Resino, Salvador
Fernandez-Rodriguez, Amanda
Jimenez-Sousa, Maria Angeles
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Pfizer
Junta de Castilla y León (España)
dc.subject.none.fl_str_mv IFNL3
SNP
Major surgery
rs12980275
Sepsis
septic shock
Survival
topic IFNL3
SNP
Major surgery
rs12980275
Sepsis
septic shock
Survival
description Interferon lambda 3 (IFNL3, previously called IL-28B) is a cytokine with effects against viral and bacterial pathogens. We aimed to analyze the IFNL3 rs12980275 SNP in patients who underwent major surgery, in order to establish its relationship with susceptibility to septic shock and septic shock-related death in these patients. We performed a case-control study on 376 patients to establish the association between IFNL3 rs12980275 SNP and the susceptibility to develop septic shock. Besides, we performed a longitudinal study among 172 septic shock patients using survival analysis with one censoring point of 28-days mortality. The IFNL3 rs12980275 polymorphism was genotyped by Agena Bioscience's MassARRAY platform. IFNL3 rs12980275 polymorphism was not associated with higher susceptibility to infection and septic shock development. Regarding survival analysis, the Kaplan-Meier analysis showed that patients with IFNL3 rs12980275 AA genotype had higher survival than patients with GG genotype (p = 0.003). The Cox regression analysis adjusted by the most relevant clinical and epidemiological characteristics showed that the GG genotype (recessive model) and the presence of the G allele (additive model) were associated with higher risk of death [adjusted hazard ratio (aHR) = 2.15, p = 0.034; aHR = 1.50, p = 0.030, respectively]. In conclusion, IFNL3 rs12980275 polymorphism was associated with septic shock-related death in patients who underwent major surgery. The A allele was linked to protection, and the G allele was associated with an increased risk of death. This is a first preliminary study that suggests for the first time a role of IFNL3 polymorphisms in the prognosis of septic shock.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-08-10
2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/10878
url http://hdl.handle.net/20.500.12105/10878
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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