NMR and molecular recognition of compounds related to the immune system.

227 p.

Detalles Bibliográficos
Autor: Nobre Coelho, Helena María
Tipo de recurso: tesis doctoral
Fecha de publicación:2019
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/37386
Acceso en línea:http://hdl.handle.net/10810/37386
Access Level:acceso abierto
Palabra clave:magnetic resonance spectroscopy
enzymology
glucides
espectroscopia de resonancia magnética
enzimología
glúcidos
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spelling NMR and molecular recognition of compounds related to the immune system.Nobre Coelho, Helena Maríamagnetic resonance spectroscopyenzymologyglucidesespectroscopia de resonancia magnéticaenzimologíaglúcidos227 p.Glycans are among the most varied and complex molecules in biological systems. The glycosylation process is the most complex and widespread modification of proteins and lipids, with an unsurpassed capacity to generate a wide array of different structures. Recognition of glycans by specific receptors translates the glycome into unprecedented biological signals in physiological and pathological events. In this work, we applied Nuclear Magnetic Resonance (NMR) spectroscopy to gain structural insights of different molecular recognition processes between glycans and diverse proteins with biomedical relevance. As key highlight, key aspects of the glycosylation mechanism of MUC1 by GalNAc-Transferases (GalNAc-Ts) have been unraveled, paying special attention to the site-specificity of the process. Furthermore, our targets have an important impact in disease, particularly, in cancer (mucin-1) and in bacterial infections (Toll-like receptor 4). Throughout this Thesis, state-of-the-art NMR experiments have been applied to dissect the molecular details of these biomolecular recognition processes. Thus, ligand-based and receptor-based methods have been used, in combination with a variety of additional experimental and theoretical techniques. Thus, biophysical, biochemical, molecular biology and computational methodologies have complemented the NMR data in order to attain a complete description of the interaction events.CICBioGUNE UcibioJiménez Barbero, JesúsLete Expósito, María Esther2019201920192019info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10810/37386reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/semantics/openAccess(c)2019 HELENA MARIA NOBRE COELHOoai:addi.ehu.eus:10810/373862026-06-18T09:23:17Z
dc.title.none.fl_str_mv NMR and molecular recognition of compounds related to the immune system.
title NMR and molecular recognition of compounds related to the immune system.
spellingShingle NMR and molecular recognition of compounds related to the immune system.
Nobre Coelho, Helena María
magnetic resonance spectroscopy
enzymology
glucides
espectroscopia de resonancia magnética
enzimología
glúcidos
title_short NMR and molecular recognition of compounds related to the immune system.
title_full NMR and molecular recognition of compounds related to the immune system.
title_fullStr NMR and molecular recognition of compounds related to the immune system.
title_full_unstemmed NMR and molecular recognition of compounds related to the immune system.
title_sort NMR and molecular recognition of compounds related to the immune system.
dc.creator.none.fl_str_mv Nobre Coelho, Helena María
author Nobre Coelho, Helena María
author_facet Nobre Coelho, Helena María
author_role author
dc.contributor.none.fl_str_mv Jiménez Barbero, Jesús
Lete Expósito, María Esther
dc.subject.none.fl_str_mv magnetic resonance spectroscopy
enzymology
glucides
espectroscopia de resonancia magnética
enzimología
glúcidos
topic magnetic resonance spectroscopy
enzymology
glucides
espectroscopia de resonancia magnética
enzimología
glúcidos
description 227 p.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/37386
url http://hdl.handle.net/10810/37386
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
(c)2019 HELENA MARIA NOBRE COELHO
eu_rights_str_mv openAccess
rights_invalid_str_mv (c)2019 HELENA MARIA NOBRE COELHO
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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