How Relevant are Male Factors for Fertilization and Early Embryo Development? Looking into the (Epi)genome, Proteome and Metabolome

Infertility affects 10-15% of couples at the age of conception. Mounting evidence supports that not only are paternal factors crucial during fertilization, but also for embryogenesis. This review aims to provide some clues about the contribution of male factors to reproductive success and live birth...

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Detalles Bibliográficos
Autor: Yeste Oliveras, Marc
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/26474
Acceso en línea:http://hdl.handle.net/10256/26474
Access Level:acceso abierto
Palabra clave:Espermatozoides
Reproducció humana
Fecunditat humana
Esterilitat masculina
Embriologia humana
Spermatozoa
Human reproduction
Human fertility
Male sterility
Human embryology
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spelling How Relevant are Male Factors for Fertilization and Early Embryo Development? Looking into the (Epi)genome, Proteome and MetabolomeYeste Oliveras, MarcEspermatozoidesReproducció humanaFecunditat humanaEsterilitat masculinaEmbriologia humanaSpermatozoaHuman reproductionHuman fertilityMale sterilityHuman embryologyInfertility affects 10-15% of couples at the age of conception. Mounting evidence supports that not only are paternal factors crucial during fertilization, but also for embryogenesis. This review aims to provide some clues about the contribution of male factors to reproductive success and live birth, as such contributions can be as important as that of the female. Semen is composed of two fractions: sperm and seminal plasma. Regarding the former, the integrity of sperm components (i.e., centrioles, DNA integrity and methylation, histone-to-protamine ration, specific proteins, etc.) has been proven to be essential for some of the events occurring upon engulfment of the spermatozoon into the oocyte cytoplasm. The metabolic status of sperm also seems to shape their potential fertilizing capacity. Furthermore, seminal plasma appears to modulate the female reproductive tract, and has been suggested to support embryo implantation. In spite of the aforementioned, it remains largely unaddressed how paternal factors interact with maternal ones, and whether the latter may mask the former. While assisted reproductive techniques (ART) are useful to rescue infertility, a better understanding about the contribution of semen to fertilization, embryo development and implantation can increase the efficiency of these techniques, and address further the causes of total fertilization failure, implantation deficiency and recurrent miscarriageThe author also acknowledges the support from the Regional Government of Catalonia, Spain (2017-SGR-1229) and the Catalan Institution for Research and Advanced Studies (ICREA)Open Access funding provided thanks to the CSUC agreement with Cambridge University Press (CUP)2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewed33 p.application/pdfhttp://hdl.handle.net/10256/26474European Review, 2024, vol. 32, núm. 4, p. 346-378Articles publicats (D-B)Yeste Oliveras, Marc 2025 How much relevant are male factors for fertilization and early embryo development? Looking into the (epi)genome, proteome and metabolome European Review undef undef 1 33reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1017/S1062798724000231info:eu-repo/semantics/altIdentifier/issn/1062-7987info:eu-repo/semantics/altIdentifier/eissn/1474-0575Reconeixement-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:10256/264742026-05-29T05:05:01Z
dc.title.none.fl_str_mv How Relevant are Male Factors for Fertilization and Early Embryo Development? Looking into the (Epi)genome, Proteome and Metabolome
title How Relevant are Male Factors for Fertilization and Early Embryo Development? Looking into the (Epi)genome, Proteome and Metabolome
spellingShingle How Relevant are Male Factors for Fertilization and Early Embryo Development? Looking into the (Epi)genome, Proteome and Metabolome
Yeste Oliveras, Marc
Espermatozoides
Reproducció humana
Fecunditat humana
Esterilitat masculina
Embriologia humana
Spermatozoa
Human reproduction
Human fertility
Male sterility
Human embryology
title_short How Relevant are Male Factors for Fertilization and Early Embryo Development? Looking into the (Epi)genome, Proteome and Metabolome
title_full How Relevant are Male Factors for Fertilization and Early Embryo Development? Looking into the (Epi)genome, Proteome and Metabolome
title_fullStr How Relevant are Male Factors for Fertilization and Early Embryo Development? Looking into the (Epi)genome, Proteome and Metabolome
title_full_unstemmed How Relevant are Male Factors for Fertilization and Early Embryo Development? Looking into the (Epi)genome, Proteome and Metabolome
title_sort How Relevant are Male Factors for Fertilization and Early Embryo Development? Looking into the (Epi)genome, Proteome and Metabolome
dc.creator.none.fl_str_mv Yeste Oliveras, Marc
author Yeste Oliveras, Marc
author_facet Yeste Oliveras, Marc
author_role author
dc.subject.none.fl_str_mv Espermatozoides
Reproducció humana
Fecunditat humana
Esterilitat masculina
Embriologia humana
Spermatozoa
Human reproduction
Human fertility
Male sterility
Human embryology
topic Espermatozoides
Reproducció humana
Fecunditat humana
Esterilitat masculina
Embriologia humana
Spermatozoa
Human reproduction
Human fertility
Male sterility
Human embryology
description Infertility affects 10-15% of couples at the age of conception. Mounting evidence supports that not only are paternal factors crucial during fertilization, but also for embryogenesis. This review aims to provide some clues about the contribution of male factors to reproductive success and live birth, as such contributions can be as important as that of the female. Semen is composed of two fractions: sperm and seminal plasma. Regarding the former, the integrity of sperm components (i.e., centrioles, DNA integrity and methylation, histone-to-protamine ration, specific proteins, etc.) has been proven to be essential for some of the events occurring upon engulfment of the spermatozoon into the oocyte cytoplasm. The metabolic status of sperm also seems to shape their potential fertilizing capacity. Furthermore, seminal plasma appears to modulate the female reproductive tract, and has been suggested to support embryo implantation. In spite of the aforementioned, it remains largely unaddressed how paternal factors interact with maternal ones, and whether the latter may mask the former. While assisted reproductive techniques (ART) are useful to rescue infertility, a better understanding about the contribution of semen to fertilization, embryo development and implantation can increase the efficiency of these techniques, and address further the causes of total fertilization failure, implantation deficiency and recurrent miscarriage
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/26474
url http://hdl.handle.net/10256/26474
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1017/S1062798724000231
info:eu-repo/semantics/altIdentifier/issn/1062-7987
info:eu-repo/semantics/altIdentifier/eissn/1474-0575
dc.rights.none.fl_str_mv Reconeixement-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reconeixement-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 33 p.
application/pdf
dc.source.none.fl_str_mv European Review, 2024, vol. 32, núm. 4, p. 346-378
Articles publicats (D-B)
Yeste Oliveras, Marc 2025 How much relevant are male factors for fertilization and early embryo development? Looking into the (epi)genome, proteome and metabolome European Review undef undef 1 33
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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