Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate

How odd! A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular...

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Autores: Maga, Giovanni, Radi, Marco, Zanoli, Samantha, Manetti, Fabrizio, Cancio, Reynel, Hübscher, Ulrich, Spadari, Silvio, Falciani, Chiara, Terrazas Martínez, Montserrat, Vilarrasa i Llorens, Jaume, Botta, Maurizio
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2007
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183770
Acceso en línea:https://hdl.handle.net/2445/183770
Access Level:acceso abierto
Palabra clave:Nucleòsids
Pirimidines
Radiocristal·lografia
Nucleosides
Pyrimidines
X-ray crystallography
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spelling Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrateMaga, GiovanniRadi, MarcoZanoli, SamanthaManetti, FabrizioCancio, ReynelHübscher, UlrichSpadari, SilvioFalciani, ChiaraTerrazas Martínez, MontserratVilarrasa i Llorens, JaumeBotta, MaurizioNucleòsidsPirimidinesRadiocristal·lografiaNucleosidesPyrimidinesX-ray crystallographyHow odd! A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.Wiley-VCH2007info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/183770Articles publicats en revistes (Química Inorgànica i Orgànica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1002/anie.200604165Angewandte Chemie-International Edition, 2007, vol. 46, num. 11, p. 1810-1813https://doi.org/10.1002/anie.200604165(c) Wiley-VCH, 2007info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1837702026-05-27T06:46:51Z
dc.title.none.fl_str_mv Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate
title Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate
spellingShingle Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate
Maga, Giovanni
Nucleòsids
Pirimidines
Radiocristal·lografia
Nucleosides
Pyrimidines
X-ray crystallography
title_short Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate
title_full Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate
title_fullStr Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate
title_full_unstemmed Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate
title_sort Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate
dc.creator.none.fl_str_mv Maga, Giovanni
Radi, Marco
Zanoli, Samantha
Manetti, Fabrizio
Cancio, Reynel
Hübscher, Ulrich
Spadari, Silvio
Falciani, Chiara
Terrazas Martínez, Montserrat
Vilarrasa i Llorens, Jaume
Botta, Maurizio
author Maga, Giovanni
author_facet Maga, Giovanni
Radi, Marco
Zanoli, Samantha
Manetti, Fabrizio
Cancio, Reynel
Hübscher, Ulrich
Spadari, Silvio
Falciani, Chiara
Terrazas Martínez, Montserrat
Vilarrasa i Llorens, Jaume
Botta, Maurizio
author_role author
author2 Radi, Marco
Zanoli, Samantha
Manetti, Fabrizio
Cancio, Reynel
Hübscher, Ulrich
Spadari, Silvio
Falciani, Chiara
Terrazas Martínez, Montserrat
Vilarrasa i Llorens, Jaume
Botta, Maurizio
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Nucleòsids
Pirimidines
Radiocristal·lografia
Nucleosides
Pyrimidines
X-ray crystallography
topic Nucleòsids
Pirimidines
Radiocristal·lografia
Nucleosides
Pyrimidines
X-ray crystallography
description How odd! A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.
publishDate 2007
dc.date.none.fl_str_mv 2007
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183770
url https://hdl.handle.net/2445/183770
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/anie.200604165
Angewandte Chemie-International Edition, 2007, vol. 46, num. 11, p. 1810-1813
https://doi.org/10.1002/anie.200604165
dc.rights.none.fl_str_mv (c) Wiley-VCH, 2007
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley-VCH, 2007
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv Articles publicats en revistes (Química Inorgànica i Orgànica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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