Paraneoplastic neurologic syndromes associated with nasopharyngeal carcinoma: a systematic review
Introduction and objectives: Paraneoplastic syndromes (PS) are a heterogeneous group of cancer-associated disorders caused by mechanisms other than metastases, metabolic, nutritional deficits, infections, or side effects of cancer treatment PS appear in 1-7.4 % of all cancer patients. Paraneoplastic...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unican.es:10902/38709 |
| Acceso en línea: | https://hdl.handle.net/10902/38709 |
| Access Level: | acceso abierto |
| Palabra clave: | Paraneoplastic Myelitis Nasopharyngeal carcinoma Antineural antibodies Head and neck carcinoma Paraneoplásico Carcinoma nasofaríngeo Anticuerpos antineuronales Carcinoma de cabeza y cuello Mielitis |
| Sumario: | Introduction and objectives: Paraneoplastic syndromes (PS) are a heterogeneous group of cancer-associated disorders caused by mechanisms other than metastases, metabolic, nutritional deficits, infections, or side effects of cancer treatment PS appear in 1-7.4 % of all cancer patients. Paraneoplastic neurological syndromes (PNS) associated with nasopharyngeal carcinoma (NC) are very rare. The objective of this review is to characterize the PNS associated with NC. Methods: A systematic review of cases of PNS associated to NC was carried out. The following databases were used for the search: Pubmed, Web of Science and Cochrane library. As search terms we used the keywords: ?paraneoplastic syndrome? and ?nasopharyngeal carcinoma?. Results: We included a total of 11 patients in the review. The PNS most frequently identified were cerebellar degeneration, limbic encephalitis, and opsoclonus-myoclonus syndrome. Auto antibodies against neural structures were identified in 5 cases (anti-Yo, anti-Hu and anti-RI). Regarding neurological prognosis, neurological symptoms did not improve or improved only partially after both primary tumor and steroids and immunoglobulins. Conclusions: Clinicians should consider the possibility of a paraneo-plastic etiology when caring for patients with NC who present with subacute neurological symptoms. The prognosis of PNS after treatment is poor. |
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