Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase

9 p.-2 fig

Detalhes bibliográficos
Autores: Sánchez-Gómez, Francisco J., Díez-Dacal, Beatriz, García-Martín, Elena, Agúndez, José Augusto G., Pajares, María Ángeles, Pérez-Sala, Dolores
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2016
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/136341
Acesso em linha:http://hdl.handle.net/10261/136341
Access Level:Acceso aberto
Palavra-chave:Glutathione transferase
Aldose reductase
Inflammation
Oxidative stress
Detoxification
Allergy
Drug adduct
Drug hypersensitivity
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spelling Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductaseSánchez-Gómez, Francisco J.Díez-Dacal, BeatrizGarcía-Martín, ElenaAgúndez, José Augusto G.Pajares, María ÁngelesPérez-Sala, DoloresGlutathione transferaseAldose reductaseInflammationOxidative stressDetoxificationAllergyDrug adductDrug hypersensitivity9 p.-2 figPhase I and II enzymes are involved in the metabolism of endogenous reactive compounds as well as xenobiotics, including toxicants and drugs. Genotyping studies have established several drug metabolizing enzymes as markers for risk of drug hypersensitivity. However, other candidates are emerging that are involved in drug metabolism but also in the generation of danger or costimulatory signals. Enzymes such as aldo-keto reductases (AKR) and glutathione transferases (GST) metabolize prostaglandins and reactive aldehydes with proinflammatory activity, as well as drugs and/or their reactive metabolites. In addition, their metabolic activity can have important consequences for the cellular redox status, and impacts the inflammatory response as well as the balance of inflammatory mediators, which can modulate epigenetic factors and cooperate or interfere with drug-adduct formation. These enzymes are, in turn, targets for covalent modification and regulation by oxidative stress, inflammatory mediators, and drugs. Therefore, they constitute a platform for a complex set of interactions involving drug metabolism, protein haptenation, modulation of the inflammatory response, and/or generation of danger signals with implications in drug hypersensitivity reactions. Moreover, increasing evidence supports their involvement in allergic processes. Here, we will focus on GSTP1-1 and aldose reductase (AKR1B1) and provide a perspective for their involvement in drug hypersensitivityThis work has been supported by grants SAF2012-36519 from MINECO and SAF-2015-68590-R from MINECO/FEDER and ISCIII RETIC RIRAAF RD12/0013/0008 to DP,and RD12/0013/0002 to J A.Peer reviewedFrontiers MediaMinisterio de Economía y Competitividad (España)European CommissionInstituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201620162016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/136341reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-68590-Rhttp://dx.doi.org/10.3389/fphar.2016.00237Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1363412026-05-22T06:33:51Z
dc.title.none.fl_str_mv Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase
title Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase
spellingShingle Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase
Sánchez-Gómez, Francisco J.
Glutathione transferase
Aldose reductase
Inflammation
Oxidative stress
Detoxification
Allergy
Drug adduct
Drug hypersensitivity
title_short Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase
title_full Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase
title_fullStr Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase
title_full_unstemmed Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase
title_sort Detoxifying enzymes at the cross-roads of inflammation, oxidative stress, and drug hypersensitivity: role of glutathione transferase P1-1 and aldose reductase
dc.creator.none.fl_str_mv Sánchez-Gómez, Francisco J.
Díez-Dacal, Beatriz
García-Martín, Elena
Agúndez, José Augusto G.
Pajares, María Ángeles
Pérez-Sala, Dolores
author Sánchez-Gómez, Francisco J.
author_facet Sánchez-Gómez, Francisco J.
Díez-Dacal, Beatriz
García-Martín, Elena
Agúndez, José Augusto G.
Pajares, María Ángeles
Pérez-Sala, Dolores
author_role author
author2 Díez-Dacal, Beatriz
García-Martín, Elena
Agúndez, José Augusto G.
Pajares, María Ángeles
Pérez-Sala, Dolores
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Glutathione transferase
Aldose reductase
Inflammation
Oxidative stress
Detoxification
Allergy
Drug adduct
Drug hypersensitivity
topic Glutathione transferase
Aldose reductase
Inflammation
Oxidative stress
Detoxification
Allergy
Drug adduct
Drug hypersensitivity
description 9 p.-2 fig
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/136341
url http://hdl.handle.net/10261/136341
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-68590-R
http://dx.doi.org/10.3389/fphar.2016.00237
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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