Insights Into SND1 Oncogene Promoter Regulation

The staphylococcal nuclease and Tudor domain containing 1 gene (SND1), also known as Tudor-SN, TSN or p100, encodes an evolutionarily conserved protein with invariant domain composition. SND1 contains four repeated staphylococcal nuclease domains and a single Tudor domain, which confer it endonuclea...

Descripción completa

Detalles Bibliográficos
Autores: Ochoa Olascoaga, Begoña, Chico Carmona, Yolanda, Martínez San Pelayo, María José
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/30898
Acceso en línea:http://hdl.handle.net/10810/30898
Access Level:acceso abierto
Palabra clave:staphylococcal nuclease and Tudor domain containing 1
Tudor-SN
transcriptional regulation
chromosome 7 band 7q.32.1
miR-593
SND1-IT1
oncogene promoter
id ES_ff6a011bac8ffb65f864fbbfebc71212
oai_identifier_str oai:addi.ehu.eus:10810/30898
network_acronym_str ES
network_name_str España
repository_id_str
spelling Insights Into SND1 Oncogene Promoter RegulationOchoa Olascoaga, BegoñaChico Carmona, YolandaMartínez San Pelayo, María Joséstaphylococcal nuclease and Tudor domain containing 1Tudor-SNtranscriptional regulationchromosome 7 band 7q.32.1miR-593SND1-IT1oncogene promoterThe staphylococcal nuclease and Tudor domain containing 1 gene (SND1), also known as Tudor-SN, TSN or p100, encodes an evolutionarily conserved protein with invariant domain composition. SND1 contains four repeated staphylococcal nuclease domains and a single Tudor domain, which confer it endonuclease activity and extraordinary capacity for interacting with nucleic acids, individual proteins and protein complexes. Originally described as a transcriptional coactivator, SND1 plays fundamental roles in the regulation of gene expression, including RNA splicing, interference, stability, and editing, as well as in the regulation of protein and lipid homeostasis. Recently, SND1 has gained attention as a potential disease biomarker due to its positive correlation with cancer progression and metastatic spread. Such functional diversity of SND1 marks this gene as interesting for further analysis in relation with the multiple levels of regulation of SND1 protein production. In this review, we summarize the SND1 genomic region and promoter architecture, the set of transcription factors that can bind the proximal promoter, and the evidence supporting transactivation of SND1 promoter by a number of signal transduction pathways operating in different cell types and conditions. Unraveling the mechanisms responsible for SND1 promoter regulation is of utmost interest to decipher the SND1 contribution in the realm of both normal and abnormal physiology.Work in the authors' lab is supported by Spanish Ministry of Economy, Industry and Competitiveness grants SAF-2015-64352-R and RTC-2015-3693-1 and Basque Government grants IT-971-16 and KK2018-00090.Frontiers Media SA201920192018info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/30898reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/SAF-2015-64352-R/info:eu-repo/grantAgreement/MINECO/RTC-2015-3693-1/https://www.frontiersin.org/articles/10.3389/fonc.2018.00606/fullinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/Copyright © 2018 Ochoa, Chico and Martínez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Atribución 3.0 Españaoai:addi.ehu.eus:10810/308982026-06-18T09:23:17Z
dc.title.none.fl_str_mv Insights Into SND1 Oncogene Promoter Regulation
title Insights Into SND1 Oncogene Promoter Regulation
spellingShingle Insights Into SND1 Oncogene Promoter Regulation
Ochoa Olascoaga, Begoña
staphylococcal nuclease and Tudor domain containing 1
Tudor-SN
transcriptional regulation
chromosome 7 band 7q.32.1
miR-593
SND1-IT1
oncogene promoter
title_short Insights Into SND1 Oncogene Promoter Regulation
title_full Insights Into SND1 Oncogene Promoter Regulation
title_fullStr Insights Into SND1 Oncogene Promoter Regulation
title_full_unstemmed Insights Into SND1 Oncogene Promoter Regulation
title_sort Insights Into SND1 Oncogene Promoter Regulation
dc.creator.none.fl_str_mv Ochoa Olascoaga, Begoña
Chico Carmona, Yolanda
Martínez San Pelayo, María José
author Ochoa Olascoaga, Begoña
author_facet Ochoa Olascoaga, Begoña
Chico Carmona, Yolanda
Martínez San Pelayo, María José
author_role author
author2 Chico Carmona, Yolanda
Martínez San Pelayo, María José
author2_role author
author
dc.subject.none.fl_str_mv staphylococcal nuclease and Tudor domain containing 1
Tudor-SN
transcriptional regulation
chromosome 7 band 7q.32.1
miR-593
SND1-IT1
oncogene promoter
topic staphylococcal nuclease and Tudor domain containing 1
Tudor-SN
transcriptional regulation
chromosome 7 band 7q.32.1
miR-593
SND1-IT1
oncogene promoter
description The staphylococcal nuclease and Tudor domain containing 1 gene (SND1), also known as Tudor-SN, TSN or p100, encodes an evolutionarily conserved protein with invariant domain composition. SND1 contains four repeated staphylococcal nuclease domains and a single Tudor domain, which confer it endonuclease activity and extraordinary capacity for interacting with nucleic acids, individual proteins and protein complexes. Originally described as a transcriptional coactivator, SND1 plays fundamental roles in the regulation of gene expression, including RNA splicing, interference, stability, and editing, as well as in the regulation of protein and lipid homeostasis. Recently, SND1 has gained attention as a potential disease biomarker due to its positive correlation with cancer progression and metastatic spread. Such functional diversity of SND1 marks this gene as interesting for further analysis in relation with the multiple levels of regulation of SND1 protein production. In this review, we summarize the SND1 genomic region and promoter architecture, the set of transcription factors that can bind the proximal promoter, and the evidence supporting transactivation of SND1 promoter by a number of signal transduction pathways operating in different cell types and conditions. Unraveling the mechanisms responsible for SND1 promoter regulation is of utmost interest to decipher the SND1 contribution in the realm of both normal and abnormal physiology.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/30898
url http://hdl.handle.net/10810/30898
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/SAF-2015-64352-R/
info:eu-repo/grantAgreement/MINECO/RTC-2015-3693-1/
https://www.frontiersin.org/articles/10.3389/fonc.2018.00606/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425772584763392
score 15,301629

Similares en LA Referencia