Voluntary wheel running preserves lumbar perineuronal nets, enhances motor functions and prevents hyperreflexia after spinal cord injury

Perineuronal nets (PNN) are a promising candidate to harness neural plasticity since their activity-dependent modulation allows to either stabilize the circuits or increase plasticity. Modulation of plasticity is the basis of rehabilitation strategies to reduce maladaptive plasticity after spinal co...

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Autores: Sánchez-Ventura, J., Gimenez-Llort, Lydia|||0000-0002-4091-489X, Penas Pérez, Clara|||0000-0003-0554-3832, Udina i Bonet, Esther|||0000-0003-1954-8562
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:266960
Acceso en línea:https://ddd.uab.cat/record/266960
https://dx.doi.org/urn:doi:10.1016/j.expneurol.2020.113533
Access Level:acceso abierto
Palabra clave:Activity-dependent therapy
Hyperreflexia
Motoneurons
Neuropathic pain
Perineuronal nets
Physical activity
Spinal cord injury
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spelling Voluntary wheel running preserves lumbar perineuronal nets, enhances motor functions and prevents hyperreflexia after spinal cord injurySánchez-Ventura, J.Gimenez-Llort, Lydia|||0000-0002-4091-489XPenas Pérez, Clara|||0000-0003-0554-3832Udina i Bonet, Esther|||0000-0003-1954-8562Activity-dependent therapyHyperreflexiaMotoneuronsNeuropathic painPerineuronal netsPhysical activitySpinal cord injuryPerineuronal nets (PNN) are a promising candidate to harness neural plasticity since their activity-dependent modulation allows to either stabilize the circuits or increase plasticity. Modulation of plasticity is the basis of rehabilitation strategies to reduce maladaptive plasticity after spinal cord injuries (SCI). Hence, it is important to understand how spinal PNN are affected after SCI and rehabilitation. Thus, this work aims to describe functional and PNN changes after thoracic SCI in mice, followed by different activity-dependent therapies: enriched environment, voluntary wheel and forced treadmill running. We found that the contusion provoked thermal hyperalgesia, hyperreflexia and locomotor impairment as measured by thermal plantar test, H wave recordings and the BMS score of locomotion, respectively. In the spinal cord, SCI reduced PNN density around lumbar motoneurons. In contrast, activity-based therapies increased motoneuron activity and reversed PNN decrease. The voluntary wheel group showed full preservation of PNN which also correlated with reduced hyperreflexia and better locomotor recovery. Furthermore, both voluntary wheel and treadmill running reduced hyperalgesia, but this finding was independent of lumbar PNN levels. In the brainstem sensory nuclei, SCI did not modify PNN whereas some activity-based therapies reduced them. The results of the present study highlight the impact of SCI on decreasing PNN at caudal segments of the spinal cord and the potential of physical activity-based therapies to reverse PNN disaggregation and to improve functional recovery. As modulating plasticity is crucial for restoring damaged neural circuits, regulating PNN by activity is an encouraging target to improve the outcome after injury. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501SMURhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/266960https://dx.doi.org/urn:doi:10.1016/j.expneurol.2020.113533reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2669602026-06-06T12:50:31Z
dc.title.none.fl_str_mv Voluntary wheel running preserves lumbar perineuronal nets, enhances motor functions and prevents hyperreflexia after spinal cord injury
title Voluntary wheel running preserves lumbar perineuronal nets, enhances motor functions and prevents hyperreflexia after spinal cord injury
spellingShingle Voluntary wheel running preserves lumbar perineuronal nets, enhances motor functions and prevents hyperreflexia after spinal cord injury
Sánchez-Ventura, J.
Activity-dependent therapy
Hyperreflexia
Motoneurons
Neuropathic pain
Perineuronal nets
Physical activity
Spinal cord injury
title_short Voluntary wheel running preserves lumbar perineuronal nets, enhances motor functions and prevents hyperreflexia after spinal cord injury
title_full Voluntary wheel running preserves lumbar perineuronal nets, enhances motor functions and prevents hyperreflexia after spinal cord injury
title_fullStr Voluntary wheel running preserves lumbar perineuronal nets, enhances motor functions and prevents hyperreflexia after spinal cord injury
title_full_unstemmed Voluntary wheel running preserves lumbar perineuronal nets, enhances motor functions and prevents hyperreflexia after spinal cord injury
title_sort Voluntary wheel running preserves lumbar perineuronal nets, enhances motor functions and prevents hyperreflexia after spinal cord injury
dc.creator.none.fl_str_mv Sánchez-Ventura, J.
Gimenez-Llort, Lydia|||0000-0002-4091-489X
Penas Pérez, Clara|||0000-0003-0554-3832
Udina i Bonet, Esther|||0000-0003-1954-8562
author Sánchez-Ventura, J.
author_facet Sánchez-Ventura, J.
Gimenez-Llort, Lydia|||0000-0002-4091-489X
Penas Pérez, Clara|||0000-0003-0554-3832
Udina i Bonet, Esther|||0000-0003-1954-8562
author_role author
author2 Gimenez-Llort, Lydia|||0000-0002-4091-489X
Penas Pérez, Clara|||0000-0003-0554-3832
Udina i Bonet, Esther|||0000-0003-1954-8562
author2_role author
author
author
dc.subject.none.fl_str_mv Activity-dependent therapy
Hyperreflexia
Motoneurons
Neuropathic pain
Perineuronal nets
Physical activity
Spinal cord injury
topic Activity-dependent therapy
Hyperreflexia
Motoneurons
Neuropathic pain
Perineuronal nets
Physical activity
Spinal cord injury
description Perineuronal nets (PNN) are a promising candidate to harness neural plasticity since their activity-dependent modulation allows to either stabilize the circuits or increase plasticity. Modulation of plasticity is the basis of rehabilitation strategies to reduce maladaptive plasticity after spinal cord injuries (SCI). Hence, it is important to understand how spinal PNN are affected after SCI and rehabilitation. Thus, this work aims to describe functional and PNN changes after thoracic SCI in mice, followed by different activity-dependent therapies: enriched environment, voluntary wheel and forced treadmill running. We found that the contusion provoked thermal hyperalgesia, hyperreflexia and locomotor impairment as measured by thermal plantar test, H wave recordings and the BMS score of locomotion, respectively. In the spinal cord, SCI reduced PNN density around lumbar motoneurons. In contrast, activity-based therapies increased motoneuron activity and reversed PNN decrease. The voluntary wheel group showed full preservation of PNN which also correlated with reduced hyperreflexia and better locomotor recovery. Furthermore, both voluntary wheel and treadmill running reduced hyperalgesia, but this finding was independent of lumbar PNN levels. In the brainstem sensory nuclei, SCI did not modify PNN whereas some activity-based therapies reduced them. The results of the present study highlight the impact of SCI on decreasing PNN at caudal segments of the spinal cord and the potential of physical activity-based therapies to reverse PNN disaggregation and to improve functional recovery. As modulating plasticity is crucial for restoring damaged neural circuits, regulating PNN by activity is an encouraging target to improve the outcome after injury.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
SMUR
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format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/266960
https://dx.doi.org/urn:doi:10.1016/j.expneurol.2020.113533
url https://ddd.uab.cat/record/266960
https://dx.doi.org/urn:doi:10.1016/j.expneurol.2020.113533
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
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dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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