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Background: MicroRNAs (miRNAs) are important regulators of gene expression, with documented roles in bone metabolism and osteoporosis, suggesting potential therapeutic targets. Our aim was to identify miRNAs differentially expressed in fractured vs nonfractured bones. Additionally, we performed a mi...

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Detalles Bibliográficos
Autores: De-Ugarte, Laura, Yoskovitz, Guy, Balcells, Susana|||0000-0003-1211-1907, Güerri-Fernández, Robert|||0000-0002-9794-9161, Martinez-Diaz, Santos, Mellibovsky, Leonardo, Urreizti, Roser|||0000-0003-3617-7134, Nogués Solán, Xavier|||0000-0002-5537-1859, Grinberg, Daniel|||0000-0001-9859-2590, Garcia-Giralt, Natalia|||0000-0001-6507-0147, Díez Pérez, Adolfo|||0000-0001-8162-0209
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:186250
Acceso en línea:https://ddd.uab.cat/record/186250
https://dx.doi.org/urn:doi:10.1186/s12920-017-0272-3
Access Level:acceso abierto
Palabra clave:Osteoporosis
MicroRNAs
Osteoblast
Fracture
Epigenetic regulation
Descripción
Sumario:Background: MicroRNAs (miRNAs) are important regulators of gene expression, with documented roles in bone metabolism and osteoporosis, suggesting potential therapeutic targets. Our aim was to identify miRNAs differentially expressed in fractured vs nonfractured bones. Additionally, we performed a miRNA profiling of primary osteoblasts to assess the origin of these differentially expressed miRNAs

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