The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells

In the adult mammalian brain, most neural stem cells (NSCs) are held in a reversible state of quiescence, which is essential to avoid NSC exhaustion and determine the appropriate neurogenesis rate. NSCs of the mouse adult subependymal niche provide neurons for olfactory circuits and can be found at...

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Autores: González, Laura, Domingo Muelas, Ana, Duart Abadia, Pere, Núñez, Marc, Mikolcevic, Petra, Llonch, Elisabet, Cubillos Rojas, Mónica, Cánovas Bilbao, Begoña, Forrow, Stephen M. A., Morante Redolat, José Manuel, Fariñas, Isabel, Nebreda, Àngel R.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/201147
Acesso em linha:https://hdl.handle.net/2445/201147
Access Level:Acceso aberto
Palavra-chave:Neurociències
Biologia molecular
Neurosciences
Molecular biology
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spelling The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cellsGonzález, LauraDomingo Muelas, AnaDuart Abadia, PereNúñez, MarcMikolcevic, PetraLlonch, ElisabetCubillos Rojas, MónicaCánovas Bilbao, BegoñaForrow, Stephen M. A.Morante Redolat, José ManuelFariñas, IsabelNebreda, Àngel R.NeurociènciesBiologia molecularNeurosciencesMolecular biologyIn the adult mammalian brain, most neural stem cells (NSCs) are held in a reversible state of quiescence, which is essential to avoid NSC exhaustion and determine the appropriate neurogenesis rate. NSCs of the mouse adult subependymal niche provide neurons for olfactory circuits and can be found at different depths of quiescence, but very little is known on how their quiescence-to-activation transition is controlled. Here, we identify the atypical cyclin-dependent kinase (CDK) activator RingoA as a regulator of this process. We show that the expression of RingoA increases the levels of CDK activity and facilitates cell cycle entry of a subset of NSCs that divide slowly. Accordingly, RingoA-deficient mice exhibit reduced olfactory neurogenesis with an accumulation of quiescent NSCs. Our results indicate that RingoA plays an important role in setting the threshold of CDK activity required for adult NSCs to exit quiescence and may represent a dormancy regulator in adult mammalian tissues.© 2023 The Author(s).Elsevier2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion18 p.application/pdfhttps://hdl.handle.net/2445/201147Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.isci.2023.106202Iscience, 2023, vol. 26, num. 3https://doi.org/10.1016/j.isci.2023.106202cc by-nc-nd (c) González, Laura et al, 2023http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2011472026-05-29T05:05:01Z
dc.title.none.fl_str_mv The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
title The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
spellingShingle The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
González, Laura
Neurociències
Biologia molecular
Neurosciences
Molecular biology
title_short The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
title_full The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
title_fullStr The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
title_full_unstemmed The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
title_sort The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
dc.creator.none.fl_str_mv González, Laura
Domingo Muelas, Ana
Duart Abadia, Pere
Núñez, Marc
Mikolcevic, Petra
Llonch, Elisabet
Cubillos Rojas, Mónica
Cánovas Bilbao, Begoña
Forrow, Stephen M. A.
Morante Redolat, José Manuel
Fariñas, Isabel
Nebreda, Àngel R.
author González, Laura
author_facet González, Laura
Domingo Muelas, Ana
Duart Abadia, Pere
Núñez, Marc
Mikolcevic, Petra
Llonch, Elisabet
Cubillos Rojas, Mónica
Cánovas Bilbao, Begoña
Forrow, Stephen M. A.
Morante Redolat, José Manuel
Fariñas, Isabel
Nebreda, Àngel R.
author_role author
author2 Domingo Muelas, Ana
Duart Abadia, Pere
Núñez, Marc
Mikolcevic, Petra
Llonch, Elisabet
Cubillos Rojas, Mónica
Cánovas Bilbao, Begoña
Forrow, Stephen M. A.
Morante Redolat, José Manuel
Fariñas, Isabel
Nebreda, Àngel R.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurociències
Biologia molecular
Neurosciences
Molecular biology
topic Neurociències
Biologia molecular
Neurosciences
Molecular biology
description In the adult mammalian brain, most neural stem cells (NSCs) are held in a reversible state of quiescence, which is essential to avoid NSC exhaustion and determine the appropriate neurogenesis rate. NSCs of the mouse adult subependymal niche provide neurons for olfactory circuits and can be found at different depths of quiescence, but very little is known on how their quiescence-to-activation transition is controlled. Here, we identify the atypical cyclin-dependent kinase (CDK) activator RingoA as a regulator of this process. We show that the expression of RingoA increases the levels of CDK activity and facilitates cell cycle entry of a subset of NSCs that divide slowly. Accordingly, RingoA-deficient mice exhibit reduced olfactory neurogenesis with an accumulation of quiescent NSCs. Our results indicate that RingoA plays an important role in setting the threshold of CDK activity required for adult NSCs to exit quiescence and may represent a dormancy regulator in adult mammalian tissues.© 2023 The Author(s).
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/201147
url https://hdl.handle.net/2445/201147
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.isci.2023.106202
Iscience, 2023, vol. 26, num. 3
https://doi.org/10.1016/j.isci.2023.106202
dc.rights.none.fl_str_mv cc by-nc-nd (c) González, Laura et al, 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) González, Laura et al, 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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