Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV

A novel coronavirus recently identified in Wuhan, China (SARS-CoV-2) has expanded the number of highly pathogenic coronaviruses affecting humans. The SARS-CoV-2 represents a potential epidemic or pandemic threat, which requires a quick response for preparedness against this infection. The present re...

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Autores: Veljkovic, Veljko|||0000-0002-1980-0927, Vergara-Alert, Júlia|||0000-0001-7484-444X, Segalés Coma, Joaquim|||0000-0002-1539-7261, Paessler, Slobodan
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:dnet:uabarcelona_::d3125497419135b9f4ec493544234542
Acceso en línea:https://ddd.uab.cat/record/327107
https://dx.doi.org/urn:doi:10.12688/f1000research.22149.4
Access Level:acceso abierto
Palabra clave:2019-nCoV
Wuhan coronavirus
SARS
MERS
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spelling Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoVprediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine targetVeljkovic, Veljko|||0000-0002-1980-0927Vergara-Alert, Júlia|||0000-0001-7484-444XSegalés Coma, Joaquim|||0000-0002-1539-7261Paessler, Slobodan2019-nCoVWuhan coronavirusSARSMERSA novel coronavirus recently identified in Wuhan, China (SARS-CoV-2) has expanded the number of highly pathogenic coronaviruses affecting humans. The SARS-CoV-2 represents a potential epidemic or pandemic threat, which requires a quick response for preparedness against this infection. The present report uses the informational spectrum methodology to identify the possible origin and natural host of the new virus, as well as putative therapeutic and vaccine targets. The performed in silico analysis indicates that the newly emerging SARS-CoV-2 is closely related to severe acute respiratory syndrome (SARS)-CoV and, to a lesser degree, Middle East respiratory syndrome (MERS)-CoV. Moreover, the well-known SARS-CoV receptor (ACE2) might be a putative receptor for the novel virus as well. Actin protein was also suggested as a host factor that participates in cell entry and pathogenesis of SARS-CoV-2; therefore, drugs modulating biological activity of this protein (e.g. ibuprofen) were suggested as potential candidates for treatment of this viral infection. Additional results indicated that civets and poultry are potential candidates for the natural reservoir of the SARS-CoV-2, and that domain 288-330 of S1 protein from the SARS-CoV-2 represents promising therapeutic and/or vaccine target. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/327107https://dx.doi.org/urn:doi:10.12688/f1000research.22149.4reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::d3125497419135b9f4ec4935442345422026-06-06T12:50:31Z
dc.title.none.fl_str_mv Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV
prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target
title Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV
spellingShingle Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV
Veljkovic, Veljko|||0000-0002-1980-0927
2019-nCoV
Wuhan coronavirus
SARS
MERS
title_short Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV
title_full Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV
title_fullStr Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV
title_full_unstemmed Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV
title_sort Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV
dc.creator.none.fl_str_mv Veljkovic, Veljko|||0000-0002-1980-0927
Vergara-Alert, Júlia|||0000-0001-7484-444X
Segalés Coma, Joaquim|||0000-0002-1539-7261
Paessler, Slobodan
author Veljkovic, Veljko|||0000-0002-1980-0927
author_facet Veljkovic, Veljko|||0000-0002-1980-0927
Vergara-Alert, Júlia|||0000-0001-7484-444X
Segalés Coma, Joaquim|||0000-0002-1539-7261
Paessler, Slobodan
author_role author
author2 Vergara-Alert, Júlia|||0000-0001-7484-444X
Segalés Coma, Joaquim|||0000-0002-1539-7261
Paessler, Slobodan
author2_role author
author
author
dc.subject.none.fl_str_mv 2019-nCoV
Wuhan coronavirus
SARS
MERS
topic 2019-nCoV
Wuhan coronavirus
SARS
MERS
description A novel coronavirus recently identified in Wuhan, China (SARS-CoV-2) has expanded the number of highly pathogenic coronaviruses affecting humans. The SARS-CoV-2 represents a potential epidemic or pandemic threat, which requires a quick response for preparedness against this infection. The present report uses the informational spectrum methodology to identify the possible origin and natural host of the new virus, as well as putative therapeutic and vaccine targets. The performed in silico analysis indicates that the newly emerging SARS-CoV-2 is closely related to severe acute respiratory syndrome (SARS)-CoV and, to a lesser degree, Middle East respiratory syndrome (MERS)-CoV. Moreover, the well-known SARS-CoV receptor (ACE2) might be a putative receptor for the novel virus as well. Actin protein was also suggested as a host factor that participates in cell entry and pathogenesis of SARS-CoV-2; therefore, drugs modulating biological activity of this protein (e.g. ibuprofen) were suggested as potential candidates for treatment of this viral infection. Additional results indicated that civets and poultry are potential candidates for the natural reservoir of the SARS-CoV-2, and that domain 288-330 of S1 protein from the SARS-CoV-2 represents promising therapeutic and/or vaccine target.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/327107
https://dx.doi.org/urn:doi:10.12688/f1000research.22149.4
url https://ddd.uab.cat/record/327107
https://dx.doi.org/urn:doi:10.12688/f1000research.22149.4
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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