Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)

Blood transfusions are lifesaving procedures. In dogs, because of the absence of naturally occurring alloantibodies, the risk of an acute hemolytic transfusion reaction at the first transfusion is negligible, but mismatched transfusions might produce alloimmunization. Therefore, it is important to b...

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Autores: Silvestre-Ferreira, Ana C.|||0000-0002-7114-6918, Vilhena, Hugo|||0000-0003-3976-1619, Oliveira, Ana C.|||0000-0003-1427-8831, Mendoza, José R., Garcia Aura, Maria, Pastor Milán, Josep|||0000-0003-1702-9531
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:301798
Acceso en línea:https://ddd.uab.cat/record/301798
https://dx.doi.org/urn:doi:10.3390/vetsci11090449
Access Level:acceso abierto
Palabra clave:Africa
Angola
Alloimmunization
DEA 1
Blood typing
Blood group
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spelling Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)Silvestre-Ferreira, Ana C.|||0000-0002-7114-6918Vilhena, Hugo|||0000-0003-3976-1619Oliveira, Ana C.|||0000-0003-1427-8831Mendoza, José R.Garcia Aura, MariaPastor Milán, Josep|||0000-0003-1702-9531AfricaAngolaAlloimmunizationDEA 1Blood typingBlood groupBlood transfusions are lifesaving procedures. In dogs, because of the absence of naturally occurring alloantibodies, the risk of an acute hemolytic transfusion reaction at the first transfusion is negligible, but mismatched transfusions might produce alloimmunization. Therefore, it is important to blood type both donor and recipient dogs prior to blood transfusion. The prevalence of dog blood groups varies geographically and between breeds. The aim of this study was to determine the prevalence of DEA 1 in a canine population in Luanda province in Angola (Sub-Saharan Africa) and to assess the risk of alloimmunization after a mismatched blood transfusion. Of the 112 dogs tested (59 males and 53 females), 52.68% were DEA 1 positive and 47.32% DEA 1 negative. Female dogs presented a tendency to be DEA 1 positive and males DEA 1 negative (p = 0.0085). In a first-time mismatched blood transfusion, the calculated probability of a dog becoming sensitized was 24.9% and the probability of an acute hemolytic reaction following a second incompatible blood transfusion was 6.21%. These results differ from those of other African regions. In line with the results, blood typing is recommended prior to transfusion. In dogs, the risk of an acute hemolytic transfusion reaction at the first transfusion is negligible; however, mismatched transfusions may produce alloimmunization. To avoid fatal acute hemolytic reactions in subsequent blood transfusions, it is important to recognize blood groups and to blood type both the donor and the recipient. Prevalence of dog blood groups varies geographically and between breeds. Our aim was to determine DEA 1 prevalence in a canine population in Luanda (Angola) and to assess alloimmunization risk after a mismatched blood transfusion. Blood samples were typed using an immunochromatographic strip technique. Of the 112 dogs tested (59 males; 53 females), 52.68% were DEA 1 positive and 47.32% DEA 1 negative. Females tended to be DEA 1 positive, and males DEA 1 negative (p = 0.0085). In a first-time mismatched blood transfusion, the calculated probability of a dog becoming sensitized was 24.9% and the probability of an acute hemolytic reaction following a second incompatible blood transfusion was 6.21%. DEA 1 prevalence obtained was similar to that reported worldwide, but differs from other African countries. The risk of alloimmunization and acute hemolytic transfusion reactions in mismatched blood transfusions is higher than that in other African regions. Blood typing is recommended prior to transfusion. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/301798https://dx.doi.org/urn:doi:10.3390/vetsci11090449reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3017982026-06-06T12:50:31Z
dc.title.none.fl_str_mv Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)
title Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)
spellingShingle Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)
Silvestre-Ferreira, Ana C.|||0000-0002-7114-6918
Africa
Angola
Alloimmunization
DEA 1
Blood typing
Blood group
title_short Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)
title_full Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)
title_fullStr Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)
title_full_unstemmed Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)
title_sort Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa)
dc.creator.none.fl_str_mv Silvestre-Ferreira, Ana C.|||0000-0002-7114-6918
Vilhena, Hugo|||0000-0003-3976-1619
Oliveira, Ana C.|||0000-0003-1427-8831
Mendoza, José R.
Garcia Aura, Maria
Pastor Milán, Josep|||0000-0003-1702-9531
author Silvestre-Ferreira, Ana C.|||0000-0002-7114-6918
author_facet Silvestre-Ferreira, Ana C.|||0000-0002-7114-6918
Vilhena, Hugo|||0000-0003-3976-1619
Oliveira, Ana C.|||0000-0003-1427-8831
Mendoza, José R.
Garcia Aura, Maria
Pastor Milán, Josep|||0000-0003-1702-9531
author_role author
author2 Vilhena, Hugo|||0000-0003-3976-1619
Oliveira, Ana C.|||0000-0003-1427-8831
Mendoza, José R.
Garcia Aura, Maria
Pastor Milán, Josep|||0000-0003-1702-9531
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Africa
Angola
Alloimmunization
DEA 1
Blood typing
Blood group
topic Africa
Angola
Alloimmunization
DEA 1
Blood typing
Blood group
description Blood transfusions are lifesaving procedures. In dogs, because of the absence of naturally occurring alloantibodies, the risk of an acute hemolytic transfusion reaction at the first transfusion is negligible, but mismatched transfusions might produce alloimmunization. Therefore, it is important to blood type both donor and recipient dogs prior to blood transfusion. The prevalence of dog blood groups varies geographically and between breeds. The aim of this study was to determine the prevalence of DEA 1 in a canine population in Luanda province in Angola (Sub-Saharan Africa) and to assess the risk of alloimmunization after a mismatched blood transfusion. Of the 112 dogs tested (59 males and 53 females), 52.68% were DEA 1 positive and 47.32% DEA 1 negative. Female dogs presented a tendency to be DEA 1 positive and males DEA 1 negative (p = 0.0085). In a first-time mismatched blood transfusion, the calculated probability of a dog becoming sensitized was 24.9% and the probability of an acute hemolytic reaction following a second incompatible blood transfusion was 6.21%. These results differ from those of other African regions. In line with the results, blood typing is recommended prior to transfusion. In dogs, the risk of an acute hemolytic transfusion reaction at the first transfusion is negligible; however, mismatched transfusions may produce alloimmunization. To avoid fatal acute hemolytic reactions in subsequent blood transfusions, it is important to recognize blood groups and to blood type both the donor and the recipient. Prevalence of dog blood groups varies geographically and between breeds. Our aim was to determine DEA 1 prevalence in a canine population in Luanda (Angola) and to assess alloimmunization risk after a mismatched blood transfusion. Blood samples were typed using an immunochromatographic strip technique. Of the 112 dogs tested (59 males; 53 females), 52.68% were DEA 1 positive and 47.32% DEA 1 negative. Females tended to be DEA 1 positive, and males DEA 1 negative (p = 0.0085). In a first-time mismatched blood transfusion, the calculated probability of a dog becoming sensitized was 24.9% and the probability of an acute hemolytic reaction following a second incompatible blood transfusion was 6.21%. DEA 1 prevalence obtained was similar to that reported worldwide, but differs from other African countries. The risk of alloimmunization and acute hemolytic transfusion reactions in mismatched blood transfusions is higher than that in other African regions. Blood typing is recommended prior to transfusion.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/301798
https://dx.doi.org/urn:doi:10.3390/vetsci11090449
url https://ddd.uab.cat/record/301798
https://dx.doi.org/urn:doi:10.3390/vetsci11090449
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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