An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

A new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing alphaVbeta3 integrin compared to control D...

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Detalles Bibliográficos
Autores: Gandioso, Albert, Shaili, Evyenia, Massaguer i Vall-llovera, Anna, Artigas Solé, Gerard, González-Cantó, Alejandro, Woods, Julie A., Sadler, Peter, Marchán Sancho, Vicente
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/67182
Acceso en línea:https://hdl.handle.net/2445/67182
Access Level:acceso abierto
Palabra clave:Quimioteràpia del càncer
Cancer chemotherapy
Descripción
Sumario:A new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing alphaVbeta3 integrin compared to control DU-145 human prostate carcinoma cells.

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