B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors
Immune profile of B and T cells and tertiary lymphoid structures (TLSs) may differ in tumors of lung cancer (LC) patients with/without chronic obstructive pulmonary disease (COPD), and may also influence patient survival. We sought to analyze: (1) TLSs, germinal centers (GCs), B and T cells, and (2)...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/47024 |
| Acceso en línea: | http://hdl.handle.net/10230/47024 http://dx.doi.org/10.3390/cancers12092644 |
| Access Level: | acceso abierto |
| Palabra clave: | B cells Chronic respiratory diseases Lung cancer Overall survival Tertiary lymphoid structures |
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B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumorsTang, JunRamis Cabrer, Daniel, 1993-Curull Serrano, VíctorWang, XuejieMateu Jiménez, Mercè, 1990-Pijuan Andujar, LaraDuran Jordà, Xavier, 1974-Qin, LiyunRodríguez-Fuster, AlbertoAguiló Espases, RafaelBarreiro Portela, EstherB cellsChronic respiratory diseasesLung cancerOverall survivalTertiary lymphoid structuresImmune profile of B and T cells and tertiary lymphoid structures (TLSs) may differ in tumors of lung cancer (LC) patients with/without chronic obstructive pulmonary disease (COPD), and may also influence patient survival. We sought to analyze: (1) TLSs, germinal centers (GCs), B and T cells, and (2) associations of the immune biomarkers with the patients' 10-year overall survival (OS). TLSs (numbers and area), B [cluster of differentiation (CD) 20], and T (CD3), and GCs cells were identified in both tumor and non-tumor specimens (thoracotomy) from 90 LC-COPD patients and 43 LC-only patients. Ten-year OS was analyzed in the patients. Immune profile in tumors of LC-COPD versus LC: TLS numbers and areas significantly decreased in tumors of LC-COPD compared to LC patients. No significant differences were observed in tumors between LC-COPD and LC patients for B or T cells. Immune profile in tumors versus non-tumor specimens: TLS areas and B cells significantly increased, T cells significantly decreased in tumors of both LC and LC-COPD patients. Survival: in LC-COPD patients: greater area of TLSs and proportion of B cells were associated with longer survival rates. The immune tumor microenvironment differs in patients with underlying COPD and these different phenotypes may eventually impact the response to immunotherapy in patients with LC.MDPI202120212020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/47024http://dx.doi.org/10.3390/cancers12092644reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCancers (Basel). 2020; 12(9):2644© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/470242026-06-12T07:21:37Z |
| dc.title.none.fl_str_mv |
B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors |
| title |
B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors |
| spellingShingle |
B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors Tang, Jun B cells Chronic respiratory diseases Lung cancer Overall survival Tertiary lymphoid structures |
| title_short |
B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors |
| title_full |
B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors |
| title_fullStr |
B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors |
| title_full_unstemmed |
B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors |
| title_sort |
B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors |
| dc.creator.none.fl_str_mv |
Tang, Jun Ramis Cabrer, Daniel, 1993- Curull Serrano, Víctor Wang, Xuejie Mateu Jiménez, Mercè, 1990- Pijuan Andujar, Lara Duran Jordà, Xavier, 1974- Qin, Liyun Rodríguez-Fuster, Alberto Aguiló Espases, Rafael Barreiro Portela, Esther |
| author |
Tang, Jun |
| author_facet |
Tang, Jun Ramis Cabrer, Daniel, 1993- Curull Serrano, Víctor Wang, Xuejie Mateu Jiménez, Mercè, 1990- Pijuan Andujar, Lara Duran Jordà, Xavier, 1974- Qin, Liyun Rodríguez-Fuster, Alberto Aguiló Espases, Rafael Barreiro Portela, Esther |
| author_role |
author |
| author2 |
Ramis Cabrer, Daniel, 1993- Curull Serrano, Víctor Wang, Xuejie Mateu Jiménez, Mercè, 1990- Pijuan Andujar, Lara Duran Jordà, Xavier, 1974- Qin, Liyun Rodríguez-Fuster, Alberto Aguiló Espases, Rafael Barreiro Portela, Esther |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
B cells Chronic respiratory diseases Lung cancer Overall survival Tertiary lymphoid structures |
| topic |
B cells Chronic respiratory diseases Lung cancer Overall survival Tertiary lymphoid structures |
| description |
Immune profile of B and T cells and tertiary lymphoid structures (TLSs) may differ in tumors of lung cancer (LC) patients with/without chronic obstructive pulmonary disease (COPD), and may also influence patient survival. We sought to analyze: (1) TLSs, germinal centers (GCs), B and T cells, and (2) associations of the immune biomarkers with the patients' 10-year overall survival (OS). TLSs (numbers and area), B [cluster of differentiation (CD) 20], and T (CD3), and GCs cells were identified in both tumor and non-tumor specimens (thoracotomy) from 90 LC-COPD patients and 43 LC-only patients. Ten-year OS was analyzed in the patients. Immune profile in tumors of LC-COPD versus LC: TLS numbers and areas significantly decreased in tumors of LC-COPD compared to LC patients. No significant differences were observed in tumors between LC-COPD and LC patients for B or T cells. Immune profile in tumors versus non-tumor specimens: TLS areas and B cells significantly increased, T cells significantly decreased in tumors of both LC and LC-COPD patients. Survival: in LC-COPD patients: greater area of TLSs and proportion of B cells were associated with longer survival rates. The immune tumor microenvironment differs in patients with underlying COPD and these different phenotypes may eventually impact the response to immunotherapy in patients with LC. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/47024 http://dx.doi.org/10.3390/cancers12092644 |
| url |
http://hdl.handle.net/10230/47024 http://dx.doi.org/10.3390/cancers12092644 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Cancers (Basel). 2020; 12(9):2644 |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf application/pdf |
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MDPI |
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MDPI |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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