Brightness and shadows of mitochondrial ROS in the brain

Mitochondrial reactive oxygen species (mROS) have been generally considered harmful byproducts wanted to clear when elevated to avoid brain damage. However, the abundance of mROS in astrocytes is very high -about one order of magnitude above that in neurons-, despite they are essential to preserve c...

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Detalles Bibliográficos
Autores: Jimenez-Blasco, Daniel, Almeida, Angeles, Bolaños, Juan P.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/341188
Acceso en línea:http://hdl.handle.net/10261/341188
Access Level:acceso abierto
Palabra clave:Astrocytes
Reactive oxygen species
Mitochondria
Supercomplexes
Neurons
Glutathione
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spelling Brightness and shadows of mitochondrial ROS in the brainJimenez-Blasco, DanielAlmeida, AngelesBolaños, Juan P.AstrocytesReactive oxygen speciesMitochondriaSupercomplexesNeuronsGlutathioneMitochondrial reactive oxygen species (mROS) have been generally considered harmful byproducts wanted to clear when elevated to avoid brain damage. However, the abundance of mROS in astrocytes is very high -about one order of magnitude above that in neurons-, despite they are essential to preserve cell metabolism and animal behavior. Here, we have focused on this apparent ambiguity by discussing (i) the intrinsic mechanisms accounting for the higher production of mROS by the mitochondrial respiratory chain in astrocytes than in neurons, (ii) the specific molecular targets of astrocytic beneficial mROS, and (iii) how decreased astrocytic mROS causes excess neuronal mROS leading to cellular and organismal damage. We hope that this mini-review serves to clarifying the apparent controversy on the beneficial versus deleterious faces of ROS in the brain from molecular to higher-order organismal levels.Authors were supported by the NextGenerationEU/PRTR and Agencia Estatal de Investigación (10.13039/501100011033; PID2019-105699RB-I00; PID2022-138813OB-I00; PDC2021–121013-I00; RED2018–102576-T to JPB; RED2022–134407-T to AA); Plan Nacional de Drogas (2020I028 to JPB); Instituto de Salud Carlos III (CB16/10/00282 to JPB; PI21/00727; PMP22/00084 and RD21/0006/0005 co-funded by the European Union, to AA); Marie Sklodowska-Curie Action HORIZON-MSCA-2021-DN-01 (101072759 to JPB and AAP), and Junta de Castilla y León (CS/151P20 co-funded by P.O. FEDER to AA; Apoyo Regional a la Competitividad Empresarial, ICE 04/18/LE/0017 to JPB, and Escalera de Excelencia CLU-2017-03 to JPB and AA). DJB is a recipient of a Juan de la Cierva-Incorporación contract (IJC2020–044230-I).Peer reviewedElsevierEuropean CommissionAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Ministerio de Ciencia e Innovación (España)Instituto de Salud Carlos IIIJunta de Castilla y LeónConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/341188reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105699RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138813OB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-121013-I00info:eu-repo/grantAgreement/AEI//RED2018-102576-Tinfo:eu-repo/grantAgreement/AEI//RED2022-134407-Tinfo:eu-repo/grantAgreement/EC/HE/101072759info:eu-repo/grantAgreement/AEI//IJC2020-044230-Ihttp://dx.doi.org/10.1016/j.nbd.2023.106199Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3411882026-05-22T06:33:51Z
dc.title.none.fl_str_mv Brightness and shadows of mitochondrial ROS in the brain
title Brightness and shadows of mitochondrial ROS in the brain
spellingShingle Brightness and shadows of mitochondrial ROS in the brain
Jimenez-Blasco, Daniel
Astrocytes
Reactive oxygen species
Mitochondria
Supercomplexes
Neurons
Glutathione
title_short Brightness and shadows of mitochondrial ROS in the brain
title_full Brightness and shadows of mitochondrial ROS in the brain
title_fullStr Brightness and shadows of mitochondrial ROS in the brain
title_full_unstemmed Brightness and shadows of mitochondrial ROS in the brain
title_sort Brightness and shadows of mitochondrial ROS in the brain
dc.creator.none.fl_str_mv Jimenez-Blasco, Daniel
Almeida, Angeles
Bolaños, Juan P.
author Jimenez-Blasco, Daniel
author_facet Jimenez-Blasco, Daniel
Almeida, Angeles
Bolaños, Juan P.
author_role author
author2 Almeida, Angeles
Bolaños, Juan P.
author2_role author
author
dc.contributor.none.fl_str_mv European Commission
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Ministerio de Ciencia e Innovación (España)
Instituto de Salud Carlos III
Junta de Castilla y León
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Astrocytes
Reactive oxygen species
Mitochondria
Supercomplexes
Neurons
Glutathione
topic Astrocytes
Reactive oxygen species
Mitochondria
Supercomplexes
Neurons
Glutathione
description Mitochondrial reactive oxygen species (mROS) have been generally considered harmful byproducts wanted to clear when elevated to avoid brain damage. However, the abundance of mROS in astrocytes is very high -about one order of magnitude above that in neurons-, despite they are essential to preserve cell metabolism and animal behavior. Here, we have focused on this apparent ambiguity by discussing (i) the intrinsic mechanisms accounting for the higher production of mROS by the mitochondrial respiratory chain in astrocytes than in neurons, (ii) the specific molecular targets of astrocytic beneficial mROS, and (iii) how decreased astrocytic mROS causes excess neuronal mROS leading to cellular and organismal damage. We hope that this mini-review serves to clarifying the apparent controversy on the beneficial versus deleterious faces of ROS in the brain from molecular to higher-order organismal levels.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/341188
url http://hdl.handle.net/10261/341188
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105699RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138813OB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-121013-I00
info:eu-repo/grantAgreement/AEI//RED2018-102576-T
info:eu-repo/grantAgreement/AEI//RED2022-134407-T
info:eu-repo/grantAgreement/EC/HE/101072759
info:eu-repo/grantAgreement/AEI//IJC2020-044230-I
http://dx.doi.org/10.1016/j.nbd.2023.106199
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
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