Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate

The pain assessment in advanced dementia (PAINAD) appears to be a clinically useful tool. However, the salivary determination of tumor necrosis factor receptor type II (sTNF-RII) and secretory IgA (sIgA) as pain biomarkers is still incipient. The aim was to correlate the PAINAD score with sTNF-RII a...

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Autores: Cantón-Habas, Vanesa, Rich-Ruiz, Manuel, Moreno-Casbas, Teresa, Ramírez-Expósito, María Jesús, Martínez-Martos, Jose Manuel, Carrera-González, María Del Pilar
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/12877
Acceso en línea:http://hdl.handle.net/20.500.12105/12877
Access Level:acceso abierto
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spelling Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicateCantón-Habas, VanesaRich-Ruiz, ManuelMoreno-Casbas, TeresaRamírez-Expósito, María JesúsMartínez-Martos, Jose ManuelCarrera-González, María Del PilarThe pain assessment in advanced dementia (PAINAD) appears to be a clinically useful tool. However, the salivary determination of tumor necrosis factor receptor type II (sTNF-RII) and secretory IgA (sIgA) as pain biomarkers is still incipient. The aim was to correlate the PAINAD score with sTNF-RII and sIgA biomarker levels in the saliva of patients with advanced dementia. In this regard, a cross-sectional study was conducted. The sample consisted of 75 elderly patients with a clinical diagnosis of dementia and a global deterioration scale (GDS) score of 5 to 7. The PAINAD scale was determined by a previously trained professional and the collection of salivary samples was performed using the passive secretion method. Human sTNF-RII and sIgA using ELISA kits. The results showed a correlation between the PAINAD scale (numeric, binary, and recoded) and sTNF-RII and sIgA (p < 0.001). No association between the sociodemographic and clinical variables and the PAINAD scale was found (p > 0.05). Between 97.3% and 96.2% of patients with pain on the PAINAD scale also showed pain based on the sTNF-RII levels; in all of them, sIgA levels did not fit the logistic models. Therefore, the correlation highlights the usefulness of this scale and confirms the usefulness of sTNF-RII and sIgA as biomarkers of pain.Multidisciplinary Digital Publishing Institute (MDPI)Regional Government of Andalusia (España)20212021-05-0520212021-04-0120212021-04-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/12877reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/128772026-06-12T12:43:37Z
dc.title.none.fl_str_mv Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate
title Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate
spellingShingle Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate
Cantón-Habas, Vanesa
title_short Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate
title_full Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate
title_fullStr Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate
title_full_unstemmed Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate
title_sort Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate
dc.creator.none.fl_str_mv Cantón-Habas, Vanesa
Rich-Ruiz, Manuel
Moreno-Casbas, Teresa
Ramírez-Expósito, María Jesús
Martínez-Martos, Jose Manuel
Carrera-González, María Del Pilar
author Cantón-Habas, Vanesa
author_facet Cantón-Habas, Vanesa
Rich-Ruiz, Manuel
Moreno-Casbas, Teresa
Ramírez-Expósito, María Jesús
Martínez-Martos, Jose Manuel
Carrera-González, María Del Pilar
author_role author
author2 Rich-Ruiz, Manuel
Moreno-Casbas, Teresa
Ramírez-Expósito, María Jesús
Martínez-Martos, Jose Manuel
Carrera-González, María Del Pilar
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Regional Government of Andalusia (España)
description The pain assessment in advanced dementia (PAINAD) appears to be a clinically useful tool. However, the salivary determination of tumor necrosis factor receptor type II (sTNF-RII) and secretory IgA (sIgA) as pain biomarkers is still incipient. The aim was to correlate the PAINAD score with sTNF-RII and sIgA biomarker levels in the saliva of patients with advanced dementia. In this regard, a cross-sectional study was conducted. The sample consisted of 75 elderly patients with a clinical diagnosis of dementia and a global deterioration scale (GDS) score of 5 to 7. The PAINAD scale was determined by a previously trained professional and the collection of salivary samples was performed using the passive secretion method. Human sTNF-RII and sIgA using ELISA kits. The results showed a correlation between the PAINAD scale (numeric, binary, and recoded) and sTNF-RII and sIgA (p < 0.001). No association between the sociodemographic and clinical variables and the PAINAD scale was found (p > 0.05). Between 97.3% and 96.2% of patients with pain on the PAINAD scale also showed pain based on the sTNF-RII levels; in all of them, sIgA levels did not fit the logistic models. Therefore, the correlation highlights the usefulness of this scale and confirms the usefulness of sTNF-RII and sIgA as biomarkers of pain.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-05-05
2021
2021-04-01
2021
2021-04-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/12877
url http://hdl.handle.net/20.500.12105/12877
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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