About the existence of common determinants of gene expression in the porcine liver and skeletal muscle

[Background]: The comparison of expression QTL (eQTL) maps obtained in different tissues is an essential step to understand how gene expression is genetically regulated in a context-dependent manner. In the current work, we have compared the transcriptomic and eQTL profiles of two porcine tissues (s...

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Detalles Bibliográficos
Autores: González-Prendes, Rayner, Mármol-Sánchez, Emilio, Quintanilla, Raquel, Castelló, Anna, Zidi, Ali, Ramayo-Caldas, Yuliaxis, Figueiredo-Cardoso, T., Manunza, Arianna, Cánovas, Ángela, Amills, Marcel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/206987
Acceso en línea:http://hdl.handle.net/10261/206987
Access Level:acceso abierto
Descripción
Sumario:[Background]: The comparison of expression QTL (eQTL) maps obtained in different tissues is an essential step to understand how gene expression is genetically regulated in a context-dependent manner. In the current work, we have compared the transcriptomic and eQTL profiles of two porcine tissues (skeletal muscle and liver) which typically show highly divergent expression profiles, in 103 Duroc pigs genotyped with the Porcine SNP60 BeadChip (Illumina) and with available microarray-based measurements of hepatic and muscle mRNA levels. Since structural variation could have effects on gene expression, we have also investigated the co-localization of cis-eQTLs with copy number variant regions (CNVR) segregating in this Duroc population.