Modulation of antiviral genes by African swine fever isolates of diverse virulence

[Data availability statement] Publicly available datasets were analyzed in this study. This data can be found here: https://www.ncbi.nlm.nih.gov/ with accession numbers (KM102979) and (NC044943).

Detalles Bibliográficos
Autores: Franzoni, Giulia, Mura, Lorena, Zinellu, Susanna, Sánchez-Cordón, Pedro J., Pedrera, Miriam, Dei Giudici, Silvia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/399181
Acceso en línea:http://hdl.handle.net/10261/399181
https://api.elsevier.com/content/abstract/scopus_id/105008444161
Access Level:acceso abierto
Palabra clave:African swine fever virus
Cytokines
Interferon stimulatory genes
Macrophages
Pattern recognition receptors
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spelling Modulation of antiviral genes by African swine fever isolates of diverse virulenceFranzoni, GiuliaMura, LorenaZinellu, SusannaSánchez-Cordón, Pedro J.Pedrera, MiriamDei Giudici, SilviaAfrican swine fever virusCytokinesInterferon stimulatory genesMacrophagesPattern recognition receptors[Data availability statement] Publicly available datasets were analyzed in this study. This data can be found here: https://www.ncbi.nlm.nih.gov/ with accession numbers (KM102979) and (NC044943).African swine fever virus (ASFV), the aetiological agent of a devastating swine disease, has developed several strategies to replicate in porcine macrophages, its main target cells. In this work, we investigated the expression of 84 antiviral genes in macrophages infected with the virulent strain 26544/OG10 or the attenuated strain NH/P68. Infection with both strains caused an early activation of antiviral defenses, with up-regulation of RNA-sensing molecules and interferon-stimulating genes. However, as viral replication progresses, down-regulation of key inflammatory genes was observed, especially during infection with NH/P68, suggesting an impairment of macrophages' inflammatory response. Data generated provide a better portrait of ASFV immune evasion strategies.The author(s) declare that financial support was received for the research and/or publication of this article. This research was funded by the Italian Ministry for Health (grant number Research Project IZS SA 05/23 RC).Peer reviewedFrontiers MediaMinistero della SaluteSánchez-Cordón, Pedro J. [0000-0002-7202-6475]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/399181https://api.elsevier.com/content/abstract/scopus_id/105008444161reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3389/fvets.2025.1591709https://doi.org/10.3389/fvets.2025.1591709Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3991812026-05-22T06:33:51Z
dc.title.none.fl_str_mv Modulation of antiviral genes by African swine fever isolates of diverse virulence
title Modulation of antiviral genes by African swine fever isolates of diverse virulence
spellingShingle Modulation of antiviral genes by African swine fever isolates of diverse virulence
Franzoni, Giulia
African swine fever virus
Cytokines
Interferon stimulatory genes
Macrophages
Pattern recognition receptors
title_short Modulation of antiviral genes by African swine fever isolates of diverse virulence
title_full Modulation of antiviral genes by African swine fever isolates of diverse virulence
title_fullStr Modulation of antiviral genes by African swine fever isolates of diverse virulence
title_full_unstemmed Modulation of antiviral genes by African swine fever isolates of diverse virulence
title_sort Modulation of antiviral genes by African swine fever isolates of diverse virulence
dc.creator.none.fl_str_mv Franzoni, Giulia
Mura, Lorena
Zinellu, Susanna
Sánchez-Cordón, Pedro J.
Pedrera, Miriam
Dei Giudici, Silvia
author Franzoni, Giulia
author_facet Franzoni, Giulia
Mura, Lorena
Zinellu, Susanna
Sánchez-Cordón, Pedro J.
Pedrera, Miriam
Dei Giudici, Silvia
author_role author
author2 Mura, Lorena
Zinellu, Susanna
Sánchez-Cordón, Pedro J.
Pedrera, Miriam
Dei Giudici, Silvia
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministero della Salute
Sánchez-Cordón, Pedro J. [0000-0002-7202-6475]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv African swine fever virus
Cytokines
Interferon stimulatory genes
Macrophages
Pattern recognition receptors
topic African swine fever virus
Cytokines
Interferon stimulatory genes
Macrophages
Pattern recognition receptors
description [Data availability statement] Publicly available datasets were analyzed in this study. This data can be found here: https://www.ncbi.nlm.nih.gov/ with accession numbers (KM102979) and (NC044943).
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/399181
https://api.elsevier.com/content/abstract/scopus_id/105008444161
url http://hdl.handle.net/10261/399181
https://api.elsevier.com/content/abstract/scopus_id/105008444161
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3389/fvets.2025.1591709
https://doi.org/10.3389/fvets.2025.1591709
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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