SEOM Clinical Guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2016)

The goal of this article is to provide recommendations for the diagnosis and treatment of muscle-invasive and metastatic bladder cancer. The diagnosis of muscle-invasive bladder cancer is made by pathologic evaluation after transurethral resection. Recently, a molecular classification has been propo...

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Autores: Lazaro, M, Gallardo, E, Domenech, M, Pinto, A, Gonzalez Del Alba, Aranzazu, Puente, J, Fernandez, O, Font, Albert, Lainez, N, Vazquez, S
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/20299
Acceso en línea:http://hdl.handle.net/20.500.12105/20299
Access Level:acceso abierto
Palabra clave:Bladder cancer
Cystectomy
Chemotherapy
Clinical guidelines
Guías de Práctica Clínica como Asunto
Humanos
Músculo Esquelético
Invasividad Neoplásica
Carcinoma de Células Transicionales
España
Neoplasias de la Vejiga Urinaria
Urinary Bladder Neoplasms
Spain
Muscle, Skeletal
Neoplasm Invasiveness
Humans
Carcinoma, Transitional Cell
Practice Guidelines as Topic
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repository_id_str
spelling SEOM Clinical Guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2016)Lazaro, MGallardo, EDomenech, MPinto, AGonzalez Del Alba, AranzazuPuente, JFernandez, OFont, AlbertLainez, NVazquez, SBladder cancerCystectomyChemotherapyClinical guidelinesGuías de Práctica Clínica como AsuntoHumanosMúsculo EsqueléticoInvasividad NeoplásicaCarcinoma de Células TransicionalesEspañaNeoplasias de la Vejiga UrinariaUrinary Bladder NeoplasmsSpainMuscle, SkeletalNeoplasm InvasivenessHumansCarcinoma, Transitional CellPractice Guidelines as TopicThe goal of this article is to provide recommendations for the diagnosis and treatment of muscle-invasive and metastatic bladder cancer. The diagnosis of muscle-invasive bladder cancer is made by pathologic evaluation after transurethral resection. Recently, a molecular classification has been proposed. Staging of muscle-invasive bladder cancer must be done by computed tomography scans of the chest, abdomen and pelvis and classified on the basis of UICC system. Radical cystectomy and lymph node dissection are the treatment of choice. In muscle-invasive bladder cancer, neoadjuvant chemotherapy should be recommended in patients with good performance status and no renal function impairment. Although there is insufficient evidence for use of adjuvant chemotherapy, its use must be considered when neoadjuvant therapy had not been administered in high-risk patients. Multimodality bladder-preserving treatment in localized disease is an alternative in selected and compliant patients for whom cystectomy is not considered for clinical or personal reasons. In metastatic disease, the first-line treatment for patients must be based on cisplatin-containing combination. Vinflunine is the only drug approved for use in second line in Europe. Recently, immunotherapy treatment has demonstrated activity in this setting.Springer20242024-07-0920162016-12-0120162016-12-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/20299reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/202992026-06-12T12:43:37Z
dc.title.none.fl_str_mv SEOM Clinical Guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2016)
title SEOM Clinical Guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2016)
spellingShingle SEOM Clinical Guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2016)
Lazaro, M
Bladder cancer
Cystectomy
Chemotherapy
Clinical guidelines
Guías de Práctica Clínica como Asunto
Humanos
Músculo Esquelético
Invasividad Neoplásica
Carcinoma de Células Transicionales
España
Neoplasias de la Vejiga Urinaria
Urinary Bladder Neoplasms
Spain
Muscle, Skeletal
Neoplasm Invasiveness
Humans
Carcinoma, Transitional Cell
Practice Guidelines as Topic
title_short SEOM Clinical Guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2016)
title_full SEOM Clinical Guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2016)
title_fullStr SEOM Clinical Guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2016)
title_full_unstemmed SEOM Clinical Guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2016)
title_sort SEOM Clinical Guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2016)
dc.creator.none.fl_str_mv Lazaro, M
Gallardo, E
Domenech, M
Pinto, A
Gonzalez Del Alba, Aranzazu
Puente, J
Fernandez, O
Font, Albert
Lainez, N
Vazquez, S
author Lazaro, M
author_facet Lazaro, M
Gallardo, E
Domenech, M
Pinto, A
Gonzalez Del Alba, Aranzazu
Puente, J
Fernandez, O
Font, Albert
Lainez, N
Vazquez, S
author_role author
author2 Gallardo, E
Domenech, M
Pinto, A
Gonzalez Del Alba, Aranzazu
Puente, J
Fernandez, O
Font, Albert
Lainez, N
Vazquez, S
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Bladder cancer
Cystectomy
Chemotherapy
Clinical guidelines
Guías de Práctica Clínica como Asunto
Humanos
Músculo Esquelético
Invasividad Neoplásica
Carcinoma de Células Transicionales
España
Neoplasias de la Vejiga Urinaria
Urinary Bladder Neoplasms
Spain
Muscle, Skeletal
Neoplasm Invasiveness
Humans
Carcinoma, Transitional Cell
Practice Guidelines as Topic
topic Bladder cancer
Cystectomy
Chemotherapy
Clinical guidelines
Guías de Práctica Clínica como Asunto
Humanos
Músculo Esquelético
Invasividad Neoplásica
Carcinoma de Células Transicionales
España
Neoplasias de la Vejiga Urinaria
Urinary Bladder Neoplasms
Spain
Muscle, Skeletal
Neoplasm Invasiveness
Humans
Carcinoma, Transitional Cell
Practice Guidelines as Topic
description The goal of this article is to provide recommendations for the diagnosis and treatment of muscle-invasive and metastatic bladder cancer. The diagnosis of muscle-invasive bladder cancer is made by pathologic evaluation after transurethral resection. Recently, a molecular classification has been proposed. Staging of muscle-invasive bladder cancer must be done by computed tomography scans of the chest, abdomen and pelvis and classified on the basis of UICC system. Radical cystectomy and lymph node dissection are the treatment of choice. In muscle-invasive bladder cancer, neoadjuvant chemotherapy should be recommended in patients with good performance status and no renal function impairment. Although there is insufficient evidence for use of adjuvant chemotherapy, its use must be considered when neoadjuvant therapy had not been administered in high-risk patients. Multimodality bladder-preserving treatment in localized disease is an alternative in selected and compliant patients for whom cystectomy is not considered for clinical or personal reasons. In metastatic disease, the first-line treatment for patients must be based on cisplatin-containing combination. Vinflunine is the only drug approved for use in second line in Europe. Recently, immunotherapy treatment has demonstrated activity in this setting.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-12-01
2016
2016-12-01
2024
2024-07-09
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/20299
url http://hdl.handle.net/20.500.12105/20299
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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