BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis

Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, d...

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Autores: Welz, Patrick-Simon, Zinna, Valentina M., Symeonidi, Aikaterini, Koronowski, Kevin B., Kinouchi, Kenichiro, Smith, Jacob G., Marín Guillén, Inés, Castellanos, Andrés, Furrow, Stephen, Aragón, Ferrán, Crainiciuc, Georgiana, Prats, Neus, Martín Caballero, Juan, Hidalgo, Andrés, Sassone-Corsi, Paolo, Aznar Benitah, Salvador
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/141217
Acceso en línea:https://hdl.handle.net/2445/141217
Access Level:acceso abierto
Palabra clave:Ritmes circadiaris
Fisiologia
Circadian rhythms
Physiology
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spelling BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain HomeostasisWelz, Patrick-SimonZinna, Valentina M.Symeonidi, AikateriniKoronowski, Kevin B.Kinouchi, KenichiroSmith, Jacob G.Marín Guillén, InésCastellanos, AndrésFurrow, StephenAragón, FerránCrainiciuc, GeorgianaPrats, NeusMartín Caballero, JuanHidalgo, AndrésSassone-Corsi, PaoloAznar Benitah, SalvadorRitmes circadiarisFisiologiaCircadian rhythmsPhysiologyCircadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory branch using other Bmal1-dependent clocks to “remember” time in the absence of external cues.Elsevier2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/141217Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: http://dx.doi.org/10.1016/j.cell.2019.05.009Cell, 2019, vol. 177, num. 6, p. 1436-1447http://dx.doi.org/10.1016/j.cell.2019.05.009info:eu-repo/grantAgreement/EC/H2020/713673cc by-nc-nd (c) Welz et al., 2019http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1412172026-05-27T06:46:51Z
dc.title.none.fl_str_mv BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
title BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
spellingShingle BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
Welz, Patrick-Simon
Ritmes circadiaris
Fisiologia
Circadian rhythms
Physiology
title_short BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
title_full BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
title_fullStr BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
title_full_unstemmed BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
title_sort BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
dc.creator.none.fl_str_mv Welz, Patrick-Simon
Zinna, Valentina M.
Symeonidi, Aikaterini
Koronowski, Kevin B.
Kinouchi, Kenichiro
Smith, Jacob G.
Marín Guillén, Inés
Castellanos, Andrés
Furrow, Stephen
Aragón, Ferrán
Crainiciuc, Georgiana
Prats, Neus
Martín Caballero, Juan
Hidalgo, Andrés
Sassone-Corsi, Paolo
Aznar Benitah, Salvador
author Welz, Patrick-Simon
author_facet Welz, Patrick-Simon
Zinna, Valentina M.
Symeonidi, Aikaterini
Koronowski, Kevin B.
Kinouchi, Kenichiro
Smith, Jacob G.
Marín Guillén, Inés
Castellanos, Andrés
Furrow, Stephen
Aragón, Ferrán
Crainiciuc, Georgiana
Prats, Neus
Martín Caballero, Juan
Hidalgo, Andrés
Sassone-Corsi, Paolo
Aznar Benitah, Salvador
author_role author
author2 Zinna, Valentina M.
Symeonidi, Aikaterini
Koronowski, Kevin B.
Kinouchi, Kenichiro
Smith, Jacob G.
Marín Guillén, Inés
Castellanos, Andrés
Furrow, Stephen
Aragón, Ferrán
Crainiciuc, Georgiana
Prats, Neus
Martín Caballero, Juan
Hidalgo, Andrés
Sassone-Corsi, Paolo
Aznar Benitah, Salvador
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ritmes circadiaris
Fisiologia
Circadian rhythms
Physiology
topic Ritmes circadiaris
Fisiologia
Circadian rhythms
Physiology
description Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory branch using other Bmal1-dependent clocks to “remember” time in the absence of external cues.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/141217
url https://hdl.handle.net/2445/141217
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.cell.2019.05.009
Cell, 2019, vol. 177, num. 6, p. 1436-1447
http://dx.doi.org/10.1016/j.cell.2019.05.009
info:eu-repo/grantAgreement/EC/H2020/713673
dc.rights.none.fl_str_mv cc by-nc-nd (c) Welz et al., 2019
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Welz et al., 2019
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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