Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications

The binding processes of two Polo-like kinase inhibitors, RO3280 and GSK461364, to the human serum albumin (HSA) protein as well as the protonation equilibria of both compounds have been studied combining absorbance and fluorescence spectroscopy experiments together with density functional theory ca...

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Autores: Fernández Sainz, Jesús, Pacheco Liñán, Pedro José, Ripoll Llorente, María Consuelo, González Fuentes, Joaquín, Albaladejo Pérez, José, Bravo Pérez, Iván, Garzón-Ruiz, Andrés
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/36857
Acceso en línea:https://hdl.handle.net/10578/36857
Access Level:acceso abierto
Palabra clave:Drug−protein binding
Human serum albumin
Fluorescence spectroscopy
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spelling Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic ImplicationsFernández Sainz, JesúsPacheco Liñán, Pedro JoséRipoll Llorente, María ConsueloGonzález Fuentes, JoaquínAlbaladejo Pérez, JoséBravo Pérez, IvánGarzón-Ruiz, AndrésDrug−protein bindingHuman serum albuminFluorescence spectroscopyThe binding processes of two Polo-like kinase inhibitors, RO3280 and GSK461364, to the human serum albumin (HSA) protein as well as the protonation equilibria of both compounds have been studied combining absorbance and fluorescence spectroscopy experiments together with density functional theory calculations.American Chemical Society202420242023info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10578/36857reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/368572026-05-27T07:36:41Z
dc.title.none.fl_str_mv Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications
title Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications
spellingShingle Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications
Fernández Sainz, Jesús
Drug−protein binding
Human serum albumin
Fluorescence spectroscopy
title_short Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications
title_full Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications
title_fullStr Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications
title_full_unstemmed Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications
title_sort Unusually High Affinity of the PLK Inhibitors RO3280 and GSK461364 to HSA and Its Possible Pharmacokinetic Implications
dc.creator.none.fl_str_mv Fernández Sainz, Jesús
Pacheco Liñán, Pedro José
Ripoll Llorente, María Consuelo
González Fuentes, Joaquín
Albaladejo Pérez, José
Bravo Pérez, Iván
Garzón-Ruiz, Andrés
author Fernández Sainz, Jesús
author_facet Fernández Sainz, Jesús
Pacheco Liñán, Pedro José
Ripoll Llorente, María Consuelo
González Fuentes, Joaquín
Albaladejo Pérez, José
Bravo Pérez, Iván
Garzón-Ruiz, Andrés
author_role author
author2 Pacheco Liñán, Pedro José
Ripoll Llorente, María Consuelo
González Fuentes, Joaquín
Albaladejo Pérez, José
Bravo Pérez, Iván
Garzón-Ruiz, Andrés
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Drug−protein binding
Human serum albumin
Fluorescence spectroscopy
topic Drug−protein binding
Human serum albumin
Fluorescence spectroscopy
description The binding processes of two Polo-like kinase inhibitors, RO3280 and GSK461364, to the human serum albumin (HSA) protein as well as the protonation equilibria of both compounds have been studied combining absorbance and fluorescence spectroscopy experiments together with density functional theory calculations.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10578/36857
url https://hdl.handle.net/10578/36857
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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