Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study

Background Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high incidence of CV disease (mainly due to accelerated atherosclerosis) exhibited by axS...

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Autores: Rueda-Gotor, J, Lopez-Mejias, R, Remuzgo-Martinez, S, Pulito-Cueto, V, Corrales, A, Lera-Gomez, L, Portilla, V, Gonzalez-Mazon, I, Blanco, R, Exposito, R, Mata, C, Llorca, J, Hernandez-Hernandez, V, Rodriguez-Lozano, C, Barbarroja, N, Castro, RO, Vicente, E, Fernandez-Carballido, C, Martinez-Vidal, MP, Castro-Corredor, D, Anino-Fernandez, J, Peiteado, D, Plasencia-Rodriguez, C, Galindez-Agirregoikoa, E, Garcia-Vivar, ML, Gualillo, O, Quevedo-Abeledo, JC, Castaneda, S, Ferraz-Amaro, I, Gonzalez-Gay, MA, Genre, F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p12103
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/12103
Access Level:acceso abierto
Palabra clave:Vaspin
Axial spondyloarthritis
Biomarker
Subclinical atherosclerosis
Cardiovascular risk
Polymorphism
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spelling Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological studyRueda-Gotor, JLopez-Mejias, RRemuzgo-Martinez, SPulito-Cueto, VCorrales, ALera-Gomez, LPortilla, VGonzalez-Mazon, IBlanco, RExposito, RMata, CLlorca, JHernandez-Hernandez, VRodriguez-Lozano, CBarbarroja, NCastro, ROVicente, EFernandez-Carballido, CMartinez-Vidal, MPCastro-Corredor, DAnino-Fernandez, JPeiteado, DPlasencia-Rodriguez, CGalindez-Agirregoikoa, EGarcia-Vivar, MLGualillo, OQuevedo-Abeledo, JCCastaneda, SFerraz-Amaro, IGonzalez-Gay, MAGenre, FVaspinAxial spondyloarthritisBiomarkerSubclinical atherosclerosisCardiovascular riskPolymorphismBackground Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high incidence of CV disease (mainly due to accelerated atherosclerosis) exhibited by axSpA patients, we wondered if vaspin could also be a key molecule in this process. However, data on the role of vaspin regarding atherosclerotic disease in the context of axSpA is scarce. For this reason, we aimed to evaluate the implication of vaspin, at the genetic and serological level, in subclinical atherosclerosis and CV risk in axSpA. Methods This study included 510 patients diagnosed with axSpA. Carotid ultrasound (US) was performed to evaluate the presence of subclinical atherosclerosis. Three vaspin gene variants (rs2236242, rs7159023, and rs35262691) were genotyped by TaqMan probes. Serum vaspin levels were assessed by enzyme-linked immunosorbent assay. Statistical analysis was performed using STATA (R) v.11.1. Results Serum vaspin levels were significantly higher in female patients than in males and also in obese patients when compared to those with normal weight (p < 0.05). At the genetic level, we disclosed that the minor allele of rs2236242 (A) was associated with lower serum vaspin levels in axSpA, while the rs7159023 minor allele (A) was linked to higher serum levels (p < 0.05). When the three polymorphisms assessed were combined conforming haplotypes, we disclosed that the TGC haplotype related to high serum levels of vaspin (p = 0.01). However, no statistically significant association was observed between vaspin and markers of subclinical atherosclerosis, both at the genetic and serological level. Conclusions Our results revealed that vaspin is linked to CV risk factors that may influence on the atherosclerotic process in axSpA. Additionally, we disclosed that serum vaspin concentration is genetically modulated in a large cohort of patients with axSpA.BMC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/12103ARTHRITIS RESEARCH & THERAPYISSN: 14786354ISSNe: 14786362reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p121032026-06-11T12:45:17Z
dc.title.none.fl_str_mv Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study
title Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study
spellingShingle Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study
Rueda-Gotor, J
Vaspin
Axial spondyloarthritis
Biomarker
Subclinical atherosclerosis
Cardiovascular risk
Polymorphism
title_short Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study
title_full Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study
title_fullStr Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study
title_full_unstemmed Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study
title_sort Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study
dc.creator.none.fl_str_mv Rueda-Gotor, J
Lopez-Mejias, R
Remuzgo-Martinez, S
Pulito-Cueto, V
Corrales, A
Lera-Gomez, L
Portilla, V
Gonzalez-Mazon, I
Blanco, R
Exposito, R
Mata, C
Llorca, J
Hernandez-Hernandez, V
Rodriguez-Lozano, C
Barbarroja, N
Castro, RO
Vicente, E
Fernandez-Carballido, C
Martinez-Vidal, MP
Castro-Corredor, D
Anino-Fernandez, J
Peiteado, D
Plasencia-Rodriguez, C
Galindez-Agirregoikoa, E
Garcia-Vivar, ML
Gualillo, O
Quevedo-Abeledo, JC
Castaneda, S
Ferraz-Amaro, I
Gonzalez-Gay, MA
Genre, F
author Rueda-Gotor, J
author_facet Rueda-Gotor, J
Lopez-Mejias, R
Remuzgo-Martinez, S
Pulito-Cueto, V
Corrales, A
Lera-Gomez, L
Portilla, V
Gonzalez-Mazon, I
Blanco, R
Exposito, R
Mata, C
Llorca, J
Hernandez-Hernandez, V
Rodriguez-Lozano, C
Barbarroja, N
Castro, RO
Vicente, E
Fernandez-Carballido, C
Martinez-Vidal, MP
Castro-Corredor, D
Anino-Fernandez, J
Peiteado, D
Plasencia-Rodriguez, C
Galindez-Agirregoikoa, E
Garcia-Vivar, ML
Gualillo, O
Quevedo-Abeledo, JC
Castaneda, S
Ferraz-Amaro, I
Gonzalez-Gay, MA
Genre, F
author_role author
author2 Lopez-Mejias, R
Remuzgo-Martinez, S
Pulito-Cueto, V
Corrales, A
Lera-Gomez, L
Portilla, V
Gonzalez-Mazon, I
Blanco, R
Exposito, R
Mata, C
Llorca, J
Hernandez-Hernandez, V
Rodriguez-Lozano, C
Barbarroja, N
Castro, RO
Vicente, E
Fernandez-Carballido, C
Martinez-Vidal, MP
Castro-Corredor, D
Anino-Fernandez, J
Peiteado, D
Plasencia-Rodriguez, C
Galindez-Agirregoikoa, E
Garcia-Vivar, ML
Gualillo, O
Quevedo-Abeledo, JC
Castaneda, S
Ferraz-Amaro, I
Gonzalez-Gay, MA
Genre, F
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Vaspin
Axial spondyloarthritis
Biomarker
Subclinical atherosclerosis
Cardiovascular risk
Polymorphism
topic Vaspin
Axial spondyloarthritis
Biomarker
Subclinical atherosclerosis
Cardiovascular risk
Polymorphism
description Background Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high incidence of CV disease (mainly due to accelerated atherosclerosis) exhibited by axSpA patients, we wondered if vaspin could also be a key molecule in this process. However, data on the role of vaspin regarding atherosclerotic disease in the context of axSpA is scarce. For this reason, we aimed to evaluate the implication of vaspin, at the genetic and serological level, in subclinical atherosclerosis and CV risk in axSpA. Methods This study included 510 patients diagnosed with axSpA. Carotid ultrasound (US) was performed to evaluate the presence of subclinical atherosclerosis. Three vaspin gene variants (rs2236242, rs7159023, and rs35262691) were genotyped by TaqMan probes. Serum vaspin levels were assessed by enzyme-linked immunosorbent assay. Statistical analysis was performed using STATA (R) v.11.1. Results Serum vaspin levels were significantly higher in female patients than in males and also in obese patients when compared to those with normal weight (p < 0.05). At the genetic level, we disclosed that the minor allele of rs2236242 (A) was associated with lower serum vaspin levels in axSpA, while the rs7159023 minor allele (A) was linked to higher serum levels (p < 0.05). When the three polymorphisms assessed were combined conforming haplotypes, we disclosed that the TGC haplotype related to high serum levels of vaspin (p = 0.01). However, no statistically significant association was observed between vaspin and markers of subclinical atherosclerosis, both at the genetic and serological level. Conclusions Our results revealed that vaspin is linked to CV risk factors that may influence on the atherosclerotic process in axSpA. Additionally, we disclosed that serum vaspin concentration is genetically modulated in a large cohort of patients with axSpA.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/12103
url https://fisabio.portalinvestigacion.com/publicaciones/12103
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv ARTHRITIS RESEARCH & THERAPY
ISSN: 14786354
ISSNe: 14786362
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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