Activity of Host Antimicrobials against Multidrug-Resistant Acinetobacter baumannii Acquiring Colistin Resistance through Loss of Lipopolysaccharide

Acinetobacter baumannii can acquire resistance to the cationic peptide antibiotic colistin through complete loss of lipopolysaccharide (LPS) expression. The activities of the host cationic antimicrobials LL-37 and human lysozyme against multidrug-resistant clinical isolates of A. baumannii that acqu...

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Bibliographic Details
Authors: García Quintanilla, Meritxell de Jesús, Pulido, Marina R., Moreno-Martínez, Patricia, Martín-Peña, Reyes, López Rojas, Rafael, Pachón Díaz, Jerónimo, McConnell, Michael J.
Format: article
Status:Versión aceptada para publicación
Publication Date:2014
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/160804
Online Access:https://hdl.handle.net/11441/160804
https://doi.org/10.1128/AAC.02642-13
Access Level:Open access
Keyword:Acinetobacter baumannii
Cationic peptide antibiotic colistin
Lipopolysaccharide (LPS)
Description
Summary:Acinetobacter baumannii can acquire resistance to the cationic peptide antibiotic colistin through complete loss of lipopolysaccharide (LPS) expression. The activities of the host cationic antimicrobials LL-37 and human lysozyme against multidrug-resistant clinical isolates of A. baumannii that acquired colistin resistance through lipopolysaccharide loss were characterized. We demonstrate that LL-37 has activity against strains lacking lipopolysaccharide that is similar to that of their colistin-sensitive parent strains, whereas human lysozyme has increased activity against colistin-resistant strains lacking LPS.

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