Reversible alignment of nanoparticles and intracellular vesicles during magnetic hyperthermia experiments

This article also appears in: Celebrating Excellence in the Advanced Materials Family: Women in Materials Science.

Detalles Bibliográficos
Autores: Fernández-Afonso, Yilian, Ruta, Sergiu, Páez-Muñoz, Jose María, Zanten, Thomas S. van, Gleadhall, Sian, Fratila, Raluca M., Moros, María, Morales, María Del Puerto, Satoh, Akira, Chantrell, Roy W., Serantes, David, Gutiérrez, Lucía
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/381383
Acceso en línea:http://hdl.handle.net/10261/381383
Access Level:acceso abierto
id ES_fee8d928fbf257a08fda45ca47affdda
oai_identifier_str oai:digital.csic.es:10261/381383
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Reversible alignment of nanoparticles and intracellular vesicles during magnetic hyperthermia experiments
title Reversible alignment of nanoparticles and intracellular vesicles during magnetic hyperthermia experiments
spellingShingle Reversible alignment of nanoparticles and intracellular vesicles during magnetic hyperthermia experiments
Fernández-Afonso, Yilian
title_short Reversible alignment of nanoparticles and intracellular vesicles during magnetic hyperthermia experiments
title_full Reversible alignment of nanoparticles and intracellular vesicles during magnetic hyperthermia experiments
title_fullStr Reversible alignment of nanoparticles and intracellular vesicles during magnetic hyperthermia experiments
title_full_unstemmed Reversible alignment of nanoparticles and intracellular vesicles during magnetic hyperthermia experiments
title_sort Reversible alignment of nanoparticles and intracellular vesicles during magnetic hyperthermia experiments
dc.creator.none.fl_str_mv Fernández-Afonso, Yilian
Ruta, Sergiu
Páez-Muñoz, Jose María
Zanten, Thomas S. van
Gleadhall, Sian
Fratila, Raluca M.
Moros, María
Morales, María Del Puerto
Satoh, Akira
Chantrell, Roy W.
Serantes, David
Gutiérrez, Lucía
author Fernández-Afonso, Yilian
author_facet Fernández-Afonso, Yilian
Ruta, Sergiu
Páez-Muñoz, Jose María
Zanten, Thomas S. van
Gleadhall, Sian
Fratila, Raluca M.
Moros, María
Morales, María Del Puerto
Satoh, Akira
Chantrell, Roy W.
Serantes, David
Gutiérrez, Lucía
author_role author
author2 Ruta, Sergiu
Páez-Muñoz, Jose María
Zanten, Thomas S. van
Gleadhall, Sian
Fratila, Raluca M.
Moros, María
Morales, María Del Puerto
Satoh, Akira
Chantrell, Roy W.
Serantes, David
Gutiérrez, Lucía
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Xunta de Galicia
European Research Council
Fundación General CSIC
Centro de Supercomputación de Galicia
Gobierno de Aragón
University of Sheffield
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description This article also appears in: Celebrating Excellence in the Advanced Materials Family: Women in Materials Science.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/381383
url http://hdl.handle.net/10261/381383
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122508NB-I00
info:eu-repo/grantAgreement/AEI//CNS2023-144321
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109514RJ-I00
info:eu-repo/grantAgreement/AEI//PID2020-13480RB-I00
info:eu-repo/grantAgreement/AEI//RYC2020-029822-I
info:eu-repo/grantAgreement/EC/H2020/853468
info:eu-repo/grantAgreement/EC/H2020/101034263
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1002/adfm.202405334
https://doi.org/10.1002/adfm.202405334
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425726914035712
spelling Reversible alignment of nanoparticles and intracellular vesicles during magnetic hyperthermia experimentsFernández-Afonso, YilianRuta, SergiuPáez-Muñoz, Jose MaríaZanten, Thomas S. vanGleadhall, SianFratila, Raluca M.Moros, MaríaMorales, María Del PuertoSatoh, AkiraChantrell, Roy W.Serantes, DavidGutiérrez, LucíaThis article also appears in: Celebrating Excellence in the Advanced Materials Family: Women in Materials Science.Heating magnetic nanoparticles (MNPs) with AC (Alternating Current) magnetic fields has received significant attention in recent years, particularly for biomedical uses. However, most studies focus on characterizing the heat release, overlooking the fact that the MNPs in the viscous cell environment constitute a dynamic magnetic colloid whose configuration may evolve over time, particularly if a driving force as the AC field is applied. Aiming to shed light on this matter, in this workthe dynamics of the colloid structure during hyperthermia experiments are studied. By combining various experimental and theoretical tools, it is concluded that the AC field may drive the formation of aligned structures, and the impact that such structures may have on the associated heating is assessed. Remarkably, the results show that those field-driven structures are highly unstable for small particle sizes, rapidly disassembling upon field removal. Moreover, an analogous behavior in vitro is found, with the AC magnetic field also promoting a reversible alignment of vesicles containing the MNPs within the cells. The results suggest that the observed alignment, both of MNPs and intracellular vesicles, may be a common phenomenon in usual hyperthermia experiments, but unnoticed because of the intrinsic unstable nature of the aligned structures.Authors would like to acknowledged financial support from the following projects: Project PID2021-122508NB-I00 funded by MICIU/AEI /10.13039/501100011033 and FEDER, UE; Projects PID2019-109514RJ-100 and PID2020-13480RB-I00 funded by MICIU/AEI /10.13039/501100011033; and Project CNS2023-144321 funded by MICIU/AEI/10.13039/501100011033 and NextGenerationEU/PRTR. Xunta de Galicia was acknowledged for projects ED431F 2022/05 and ED431B 2023/055. AEI was also acknowledged for the Ramón y Cajal grant RYC2020-029822-I to D.S. Funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No 853468) was also acknowledged. Funding was also received from the European Commission through the TBMED project (DT-NMBP-02-2018, ID: 814439 to R.M.F.). In addition, the authors acknowledged the Centro de Supercomputacion de Galicia (CESGA) for computational resources. TSvZ was supported by a fellowship from the Fundación General CSIC's ComFuturo programme which had received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 101034263. The authors would like to acknowledge Fondo Social del Gobierno de Aragón (grupo DGA E15-23R), the use of Advanced Microscopy Laboratory (Universidad de Zaragoza), for access to their instrumentation and expertise. SR would like to acknowledge the Sheffield Hallam University Beowulf Cluster for computational resources.Peer reviewedWiley-VCHAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionXunta de GaliciaEuropean Research CouncilFundación General CSICCentro de Supercomputación de GaliciaGobierno de AragónUniversity of SheffieldConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/381383reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122508NB-I00info:eu-repo/grantAgreement/AEI//CNS2023-144321info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109514RJ-I00info:eu-repo/grantAgreement/AEI//PID2020-13480RB-I00info:eu-repo/grantAgreement/AEI//RYC2020-029822-Iinfo:eu-repo/grantAgreement/EC/H2020/853468info:eu-repo/grantAgreement/EC/H2020/101034263The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1002/adfm.202405334https://doi.org/10.1002/adfm.202405334Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3813832026-05-22T06:33:51Z
score 15,81155

Similares en LA Referencia