Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive Disorder

Resting-state fMRI (RS-fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS-fMRI have found abnormal connectivity in several regions of the brain, particularly in the defau...

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Autores: Demirtas, M, Tornador, C, Falcón, C, López-Solà, M, Hernández-Ribas, R, Pujol, J, Menchón, JM, Ritter, P, Cardoner, N, Soriano-Mas, C, Deco, G
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6091
Acesso em linha:https://i3pt.portalinvestigacion.com/publicaciones/6091
Access Level:acceso abierto
Palavra-chave:mood disorders
major depressive disorder
dynamic functional connectivity
resting state
fMRI
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spelling Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive DisorderDemirtas, MTornador, CFalcón, CLópez-Solà, MHernández-Ribas, RPujol, JMenchón, JMRitter, PCardoner, NSoriano-Mas, CDeco, Gmood disordersmajor depressive disorderdynamic functional connectivityresting statefMRIResting-state fMRI (RS-fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS-fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self-referential thoughts and ruminations has made the use of the resting-state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS-fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network. (C) 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.WILEY2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/6091HUMAN BRAIN MAPPINGISSN: 10659471ISSNe: 10970193reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p60912026-06-21T15:30:37Z
dc.title.none.fl_str_mv Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive Disorder
title Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive Disorder
spellingShingle Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive Disorder
Demirtas, M
mood disorders
major depressive disorder
dynamic functional connectivity
resting state
fMRI
title_short Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive Disorder
title_full Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive Disorder
title_fullStr Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive Disorder
title_full_unstemmed Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive Disorder
title_sort Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive Disorder
dc.creator.none.fl_str_mv Demirtas, M
Tornador, C
Falcón, C
López-Solà, M
Hernández-Ribas, R
Pujol, J
Menchón, JM
Ritter, P
Cardoner, N
Soriano-Mas, C
Deco, G
author Demirtas, M
author_facet Demirtas, M
Tornador, C
Falcón, C
López-Solà, M
Hernández-Ribas, R
Pujol, J
Menchón, JM
Ritter, P
Cardoner, N
Soriano-Mas, C
Deco, G
author_role author
author2 Tornador, C
Falcón, C
López-Solà, M
Hernández-Ribas, R
Pujol, J
Menchón, JM
Ritter, P
Cardoner, N
Soriano-Mas, C
Deco, G
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv mood disorders
major depressive disorder
dynamic functional connectivity
resting state
fMRI
topic mood disorders
major depressive disorder
dynamic functional connectivity
resting state
fMRI
description Resting-state fMRI (RS-fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS-fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self-referential thoughts and ruminations has made the use of the resting-state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS-fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network. (C) 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/6091
url https://i3pt.portalinvestigacion.com/publicaciones/6091
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv HUMAN BRAIN MAPPING
ISSN: 10659471
ISSNe: 10970193
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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