Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial

Phenol-rich foods consumption such as virgin olive oil (VOO) has been shown to have beneficial effects on cardiovascular diseases. The broader biochemical impact of VOO and phenol-enriched OOs remains, however, unclear. A randomized, double-blind, cross-over, controlled trial was performed with thir...

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Autores: Farràs, Marta, Swann, Jonathan Richard, Rowland, Ian, Rubió, Laura, Subirana Cachinero, Isaac, Catalán, Úrsula, Motilva, Maria José, Solà, Rosa, Covas, Maria Isabel, Blanco Vaca, Francisco, Fitó Colomer, Montserrat, Mayneris Perxachs, Jordi
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/190747
Acesso em linha:https://hdl.handle.net/2445/190747
Access Level:acceso abierto
Palavra-chave:Malalties cardiovasculars
Oli d'oliva
Cardiovascular diseases
Olive oil
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spelling Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled TrialFarràs, MartaSwann, Jonathan RichardRowland, IanRubió, LauraSubirana Cachinero, IsaacCatalán, ÚrsulaMotilva, Maria JoséSolà, RosaCovas, Maria IsabelBlanco Vaca, FranciscoFitó Colomer, MontserratMayneris Perxachs, JordiMalalties cardiovascularsOli d'olivaCardiovascular diseasesOlive oilPhenol-rich foods consumption such as virgin olive oil (VOO) has been shown to have beneficial effects on cardiovascular diseases. The broader biochemical impact of VOO and phenol-enriched OOs remains, however, unclear. A randomized, double-blind, cross-over, controlled trial was performed with thirty-three hypercholesterolemic individuals who ingested for 3-weeks (25 mL/day): (1) an OO enriched with its own olive oil phenolic compounds (PCs) (500 ppm; FOO); (2) an OO enriched with its own olive oil PCs (250 ppm) plus thyme PCs (250 ppm; FOOT); and (3) a VOO with low phenolic content (80 ppm). Serum lipid and glycemic profiles, serum H-1-NMR spectroscopy-based metabolomics, endothelial function, blood pressure, and cardiovascular risk were measured. We combined OPLS-DA with machine learning modelling to identify metabolites discrimination of the treatment groups. Both phenol-enriched OO interventions decreased the levels of glutamine, creatinine, creatine, dimethylamine, and histidine in comparison to VOO one. In addition, FOOT decreased the plasma levels of glycine and DMSO2 compared to VOO, while FOO decreased the circulating alanine concentrations but increased the plasma levels of acetone and 3-HB compared to VOO. Based on these findings, phenol-enriched OOs were shown to result in a favorable shift in the circulating metabolic phenotype, inducing a reduction in metabolites associated with cardiometabolic diseases.MDPI AG2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/190747Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/antiox11101964Antioxidants, 2022, vol. 11, núm. 10, p. 1964https://doi.org/10.3390/antiox11101964cc by (c) Farràs, Marta et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1907472026-05-27T06:46:51Z
dc.title.none.fl_str_mv Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial
title Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial
spellingShingle Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial
Farràs, Marta
Malalties cardiovasculars
Oli d'oliva
Cardiovascular diseases
Olive oil
title_short Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial
title_full Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial
title_fullStr Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial
title_full_unstemmed Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial
title_sort Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial
dc.creator.none.fl_str_mv Farràs, Marta
Swann, Jonathan Richard
Rowland, Ian
Rubió, Laura
Subirana Cachinero, Isaac
Catalán, Úrsula
Motilva, Maria José
Solà, Rosa
Covas, Maria Isabel
Blanco Vaca, Francisco
Fitó Colomer, Montserrat
Mayneris Perxachs, Jordi
author Farràs, Marta
author_facet Farràs, Marta
Swann, Jonathan Richard
Rowland, Ian
Rubió, Laura
Subirana Cachinero, Isaac
Catalán, Úrsula
Motilva, Maria José
Solà, Rosa
Covas, Maria Isabel
Blanco Vaca, Francisco
Fitó Colomer, Montserrat
Mayneris Perxachs, Jordi
author_role author
author2 Swann, Jonathan Richard
Rowland, Ian
Rubió, Laura
Subirana Cachinero, Isaac
Catalán, Úrsula
Motilva, Maria José
Solà, Rosa
Covas, Maria Isabel
Blanco Vaca, Francisco
Fitó Colomer, Montserrat
Mayneris Perxachs, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties cardiovasculars
Oli d'oliva
Cardiovascular diseases
Olive oil
topic Malalties cardiovasculars
Oli d'oliva
Cardiovascular diseases
Olive oil
description Phenol-rich foods consumption such as virgin olive oil (VOO) has been shown to have beneficial effects on cardiovascular diseases. The broader biochemical impact of VOO and phenol-enriched OOs remains, however, unclear. A randomized, double-blind, cross-over, controlled trial was performed with thirty-three hypercholesterolemic individuals who ingested for 3-weeks (25 mL/day): (1) an OO enriched with its own olive oil phenolic compounds (PCs) (500 ppm; FOO); (2) an OO enriched with its own olive oil PCs (250 ppm) plus thyme PCs (250 ppm; FOOT); and (3) a VOO with low phenolic content (80 ppm). Serum lipid and glycemic profiles, serum H-1-NMR spectroscopy-based metabolomics, endothelial function, blood pressure, and cardiovascular risk were measured. We combined OPLS-DA with machine learning modelling to identify metabolites discrimination of the treatment groups. Both phenol-enriched OO interventions decreased the levels of glutamine, creatinine, creatine, dimethylamine, and histidine in comparison to VOO one. In addition, FOOT decreased the plasma levels of glycine and DMSO2 compared to VOO, while FOO decreased the circulating alanine concentrations but increased the plasma levels of acetone and 3-HB compared to VOO. Based on these findings, phenol-enriched OOs were shown to result in a favorable shift in the circulating metabolic phenotype, inducing a reduction in metabolites associated with cardiometabolic diseases.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/190747
url https://hdl.handle.net/2445/190747
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antiox11101964
Antioxidants, 2022, vol. 11, núm. 10, p. 1964
https://doi.org/10.3390/antiox11101964
dc.rights.none.fl_str_mv cc by (c) Farràs, Marta et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Farràs, Marta et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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