Sarcopenia: molecular pathways and potential targets for intervention

Producción Científica

Detalles Bibliográficos
Autores: Pascual Fernández, Jorge, Fernández Montero, Alejandro, Córdova Martínez, Alfredo, Pastor Campos, Diego, Martínez Rodríguez, Alejandro, Roche Collado, Enrique
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/58822
Acceso en línea:https://doi.org/10.3390/ijms21228844
https://uvadoc.uva.es/handle/10324/58822
Access Level:acceso abierto
Palabra clave:Muscle strength
Muscle tone
Aging
Aging - Physiological aspects
Oxidative stress
Inflammation
Exercise
Ejercicio físico
2411 Fisiología Humana
2402.15 Envejecimiento Somático
id ES_fec93c810ea745a080bd7d99a631c5ac
oai_identifier_str oai:uvadoc.uva.es:10324/58822
network_acronym_str ES
network_name_str España
repository_id_str
spelling Sarcopenia: molecular pathways and potential targets for interventionPascual Fernández, JorgeFernández Montero, AlejandroCórdova Martínez, AlfredoPastor Campos, DiegoMartínez Rodríguez, AlejandroRoche Collado, EnriqueMuscle strengthMuscle toneAgingAging - Physiological aspectsOxidative stressInflammationExerciseEjercicio físico2411 Fisiología Humana2402.15 Envejecimiento SomáticoProducción CientíficaAging is associated with sarcopenia. The loss of strength results in decreased muscle mass and motor function. This process accelerates the progressive muscle deterioration observed in older adults, favoring the presence of debilitating pathologies. In addition, sarcopenia leads to a decrease in quality of life, significantly affecting self-sufficiency. Altogether, these results in an increase in economic resources from the National Health Systems devoted to mitigating this problem in the elderly, particularly in developed countries. Different etiological determinants are involved in the progression of the disease, including: neurological factors, endocrine alterations, as well as nutritional and lifestyle changes related to the adoption of more sedentary habits. Molecular and cellular mechanisms have not been clearly characterized, resulting in the absence of an effective treatment for sarcopenia. Nevertheless, physical activity seems to be the sole strategy to delay sarcopenia and its symptoms. The present review intends to bring together the data explaining how physical activity modulates at a molecular and cellular level all factors that predispose or favor the progression of this deteriorating pathology.Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) - (Grant 190290)Instituto de Salud Carlos III - Fondo Europeo de Desarrollo Regional (CB12/03/30038)MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/ijms21228844https://uvadoc.uva.es/handle/10324/58822reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/1422-0067/21/22/8844info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/588222026-06-13T12:44:47Z
dc.title.none.fl_str_mv Sarcopenia: molecular pathways and potential targets for intervention
title Sarcopenia: molecular pathways and potential targets for intervention
spellingShingle Sarcopenia: molecular pathways and potential targets for intervention
Pascual Fernández, Jorge
Muscle strength
Muscle tone
Aging
Aging - Physiological aspects
Oxidative stress
Inflammation
Exercise
Ejercicio físico
2411 Fisiología Humana
2402.15 Envejecimiento Somático
title_short Sarcopenia: molecular pathways and potential targets for intervention
title_full Sarcopenia: molecular pathways and potential targets for intervention
title_fullStr Sarcopenia: molecular pathways and potential targets for intervention
title_full_unstemmed Sarcopenia: molecular pathways and potential targets for intervention
title_sort Sarcopenia: molecular pathways and potential targets for intervention
dc.creator.none.fl_str_mv Pascual Fernández, Jorge
Fernández Montero, Alejandro
Córdova Martínez, Alfredo
Pastor Campos, Diego
Martínez Rodríguez, Alejandro
Roche Collado, Enrique
author Pascual Fernández, Jorge
author_facet Pascual Fernández, Jorge
Fernández Montero, Alejandro
Córdova Martínez, Alfredo
Pastor Campos, Diego
Martínez Rodríguez, Alejandro
Roche Collado, Enrique
author_role author
author2 Fernández Montero, Alejandro
Córdova Martínez, Alfredo
Pastor Campos, Diego
Martínez Rodríguez, Alejandro
Roche Collado, Enrique
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Muscle strength
Muscle tone
Aging
Aging - Physiological aspects
Oxidative stress
Inflammation
Exercise
Ejercicio físico
2411 Fisiología Humana
2402.15 Envejecimiento Somático
topic Muscle strength
Muscle tone
Aging
Aging - Physiological aspects
Oxidative stress
Inflammation
Exercise
Ejercicio físico
2411 Fisiología Humana
2402.15 Envejecimiento Somático
description Producción Científica
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/ijms21228844
https://uvadoc.uva.es/handle/10324/58822
url https://doi.org/10.3390/ijms21228844
https://uvadoc.uva.es/handle/10324/58822
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/1422-0067/21/22/8844
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425715835830272
score 15,300719

Similares en LA Referencia