Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidence

Background: The neurodevelopmental effects of high doses of ionizing radiation (IR) in children are well established. To what extent such effects exist at low-to-moderate doses is unclear. Considering the increasing exposure of the general population to low-to-moderate levels of IR, predominantly fr...

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Detalles Bibliográficos
Autores: Pasqual, Elisa, 1989-, Bosch de Basea i Gómez, Magda, 1982-, López Vicente, Mònica, 1988-, Thierry-Chef, Isabelle, Cardis, Elisabeth
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/46812
Acceso en línea:http://hdl.handle.net/10230/46812
http://dx.doi.org/10.1016/j.envint.2019.105371
Access Level:acceso abierto
Palabra clave:Child health
Epidemiology
Ionizing radiation
Low dose
Neurodevelopment
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spelling Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidencePasqual, Elisa, 1989-Bosch de Basea i Gómez, Magda, 1982-López Vicente, Mònica, 1988-Thierry-Chef, IsabelleCardis, ElisabethChild healthEpidemiologyIonizing radiationLow doseNeurodevelopmentBackground: The neurodevelopmental effects of high doses of ionizing radiation (IR) in children are well established. To what extent such effects exist at low-to-moderate doses is unclear. Considering the increasing exposure of the general population to low-to-moderate levels of IR, predominantly from diagnostic procedures, the study of these effects has become a priority for radiation protection. Objectives: We conducted a systematic review of the current evidence for possible effects of low-to-moderate IR doses received during gestation, childhood and adolescence on different domains of neurodevelopment. Data sources: Searches were performed in PubMed, Scopus, EMBASE and Psychinfo on the 6th of June 2017 and repeated in December 2018. Study eligibility criteria: We included studies evaluating the association between low-to-moderate IR doses received during gestation, childhood and adolescence, and neurodevelopmental functions. Study appraisal and synthesis methods: Studies were evaluated using the Cochrane Collaboration's risk of bias tool adapted to environmental sciences. A qualitative synthesis was performed. Results: A total of 26 manuscripts were finally selected. Populations analyzed in these publications were exposed to the following sources of IR: atomic bomb (Hiroshima and Nagasaki), diagnostic/therapeutic radiation, and Chernobyl and nuclear weapon testing fallout. There was limited evidence for an association between low-to-moderate doses of IR and a decrease in general cognition and language abilities, that is, a causal interpretation is credible, but chance or confounding cannot not be ruled out with reasonable confidence. Evidence for a possible stronger effect when exposure occurred early in life, in particular, during the fetal period, was inadequate. Evidence for an association between IR and other specific domains, including attention, executive function, memory, processing speed, visual-spatial abilities, motor and socio-emotional development, was inadequate, due to the very limited number of studies found. Limitations, conclusions, and implications of key findings: Overall, depending on the domain, there was limited to inadequate evidence for an effect of low-to-moderate IR doses on neurodevelopment. Heterogeneity across studies in terms of outcome and exposure assessment hampered any quantitative synthesis and any stronger conclusion. Future research with adequate dosimetry and covering a range of specific neurodevelopmental outcomes would likely contribute to improve the body of evidence. Systematic review registration number: The systematic review protocol was registered in PROSPERO (registration number CRD42018091902).Elsevier202120212020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/46812http://dx.doi.org/10.1016/j.envint.2019.105371reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEnviron Int. 2020; 136:105371© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).http://creativecommons.org/licenses/BY/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/468122026-06-12T07:21:37Z
dc.title.none.fl_str_mv Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidence
title Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidence
spellingShingle Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidence
Pasqual, Elisa, 1989-
Child health
Epidemiology
Ionizing radiation
Low dose
Neurodevelopment
title_short Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidence
title_full Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidence
title_fullStr Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidence
title_full_unstemmed Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidence
title_sort Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidence
dc.creator.none.fl_str_mv Pasqual, Elisa, 1989-
Bosch de Basea i Gómez, Magda, 1982-
López Vicente, Mònica, 1988-
Thierry-Chef, Isabelle
Cardis, Elisabeth
author Pasqual, Elisa, 1989-
author_facet Pasqual, Elisa, 1989-
Bosch de Basea i Gómez, Magda, 1982-
López Vicente, Mònica, 1988-
Thierry-Chef, Isabelle
Cardis, Elisabeth
author_role author
author2 Bosch de Basea i Gómez, Magda, 1982-
López Vicente, Mònica, 1988-
Thierry-Chef, Isabelle
Cardis, Elisabeth
author2_role author
author
author
author
dc.subject.none.fl_str_mv Child health
Epidemiology
Ionizing radiation
Low dose
Neurodevelopment
topic Child health
Epidemiology
Ionizing radiation
Low dose
Neurodevelopment
description Background: The neurodevelopmental effects of high doses of ionizing radiation (IR) in children are well established. To what extent such effects exist at low-to-moderate doses is unclear. Considering the increasing exposure of the general population to low-to-moderate levels of IR, predominantly from diagnostic procedures, the study of these effects has become a priority for radiation protection. Objectives: We conducted a systematic review of the current evidence for possible effects of low-to-moderate IR doses received during gestation, childhood and adolescence on different domains of neurodevelopment. Data sources: Searches were performed in PubMed, Scopus, EMBASE and Psychinfo on the 6th of June 2017 and repeated in December 2018. Study eligibility criteria: We included studies evaluating the association between low-to-moderate IR doses received during gestation, childhood and adolescence, and neurodevelopmental functions. Study appraisal and synthesis methods: Studies were evaluated using the Cochrane Collaboration's risk of bias tool adapted to environmental sciences. A qualitative synthesis was performed. Results: A total of 26 manuscripts were finally selected. Populations analyzed in these publications were exposed to the following sources of IR: atomic bomb (Hiroshima and Nagasaki), diagnostic/therapeutic radiation, and Chernobyl and nuclear weapon testing fallout. There was limited evidence for an association between low-to-moderate doses of IR and a decrease in general cognition and language abilities, that is, a causal interpretation is credible, but chance or confounding cannot not be ruled out with reasonable confidence. Evidence for a possible stronger effect when exposure occurred early in life, in particular, during the fetal period, was inadequate. Evidence for an association between IR and other specific domains, including attention, executive function, memory, processing speed, visual-spatial abilities, motor and socio-emotional development, was inadequate, due to the very limited number of studies found. Limitations, conclusions, and implications of key findings: Overall, depending on the domain, there was limited to inadequate evidence for an effect of low-to-moderate IR doses on neurodevelopment. Heterogeneity across studies in terms of outcome and exposure assessment hampered any quantitative synthesis and any stronger conclusion. Future research with adequate dosimetry and covering a range of specific neurodevelopmental outcomes would likely contribute to improve the body of evidence. Systematic review registration number: The systematic review protocol was registered in PROSPERO (registration number CRD42018091902).
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/46812
http://dx.doi.org/10.1016/j.envint.2019.105371
url http://hdl.handle.net/10230/46812
http://dx.doi.org/10.1016/j.envint.2019.105371
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environ Int. 2020; 136:105371
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/BY/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/BY/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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