Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare neurological disorder characterised by muscle weakness and impaired sensory function. The present study provides a comprehensive literature review of the burden of illness of CIDP. Methods: Systematic literature search of...

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Authors: Querol, Luis|||0000-0002-4289-8264, Crabtree, M.|||0000-0001-5310-6595, Herepath, M., Priedane, E.|||0000-0003-3600-1569, Viejo Viejo, I., Agush, S., Sommerer, P.
Format: article
Publication Date:2021
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:269630
Online Access:https://ddd.uab.cat/record/269630
https://dx.doi.org/urn:doi:10.1007/s00415-020-09998-8
Access Level:Open access
Keyword:CIDP
Burden
QoL
Epidemiology
Treatment
Cost
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spelling Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)Querol, Luis|||0000-0002-4289-8264Crabtree, M.|||0000-0001-5310-6595Herepath, M.Priedane, E.|||0000-0003-3600-1569Viejo Viejo, I.Agush, S.Sommerer, P.CIDPBurdenQoLEpidemiologyTreatmentCostBackground: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare neurological disorder characterised by muscle weakness and impaired sensory function. The present study provides a comprehensive literature review of the burden of illness of CIDP. Methods: Systematic literature search of PubMed, Embase, and key conferences in May 2019. Search terms identified studies on the epidemiology, humanistic burden, current treatment, and economic burden of CIDP published since 2009 in English. Results: Forty-five full texts and nineteen conference proceedings were identified on the epidemiology (n = 9), humanistic burden (n = 7), current treatment (n = 40), and economic burden (n = 8) of CIDP. Epidemiological studies showed incidence and prevalence of 0.2-1.6 and 0.8-8.9 per 100,000, respectively, depending on geography and diagnostic criteria. Humanistic burden studies revealed that patients experienced physical and psychosocial burden, including impaired physical function, pain and depression. Publications on current treatments reported on six main types of therapy: intravenous immunoglobulins, subcutaneous immunoglobulins, corticosteroids, plasma exchange, immunosuppressants, and immunomodulators. Treatments may be burdensome, due to adverse events and reduced independence caused by treatment administration setting. In Germany, UK, France, and the US, CIDP economic burden was driven by direct costs of treatment and hospitalisation. CIDP was associated with indirect costs driven by impaired productivity. Conclusions: This first systematic review of CIDP burden of illness demonstrates the high physical and psychosocial burden of this rare disease. Future research is required to fully characterise the burden of CIDP, and to understand how appropriate treatment can mitigate burden for patients and healthcare systems. 22021-01-0120212021-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/269630https://dx.doi.org/urn:doi:10.1007/s00415-020-09998-8reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2696302026-06-06T12:50:31Z
dc.title.none.fl_str_mv Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)
title Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)
spellingShingle Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)
Querol, Luis|||0000-0002-4289-8264
CIDP
Burden
QoL
Epidemiology
Treatment
Cost
title_short Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)
title_full Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)
title_fullStr Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)
title_full_unstemmed Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)
title_sort Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP)
dc.creator.none.fl_str_mv Querol, Luis|||0000-0002-4289-8264
Crabtree, M.|||0000-0001-5310-6595
Herepath, M.
Priedane, E.|||0000-0003-3600-1569
Viejo Viejo, I.
Agush, S.
Sommerer, P.
author Querol, Luis|||0000-0002-4289-8264
author_facet Querol, Luis|||0000-0002-4289-8264
Crabtree, M.|||0000-0001-5310-6595
Herepath, M.
Priedane, E.|||0000-0003-3600-1569
Viejo Viejo, I.
Agush, S.
Sommerer, P.
author_role author
author2 Crabtree, M.|||0000-0001-5310-6595
Herepath, M.
Priedane, E.|||0000-0003-3600-1569
Viejo Viejo, I.
Agush, S.
Sommerer, P.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CIDP
Burden
QoL
Epidemiology
Treatment
Cost
topic CIDP
Burden
QoL
Epidemiology
Treatment
Cost
description Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare neurological disorder characterised by muscle weakness and impaired sensory function. The present study provides a comprehensive literature review of the burden of illness of CIDP. Methods: Systematic literature search of PubMed, Embase, and key conferences in May 2019. Search terms identified studies on the epidemiology, humanistic burden, current treatment, and economic burden of CIDP published since 2009 in English. Results: Forty-five full texts and nineteen conference proceedings were identified on the epidemiology (n = 9), humanistic burden (n = 7), current treatment (n = 40), and economic burden (n = 8) of CIDP. Epidemiological studies showed incidence and prevalence of 0.2-1.6 and 0.8-8.9 per 100,000, respectively, depending on geography and diagnostic criteria. Humanistic burden studies revealed that patients experienced physical and psychosocial burden, including impaired physical function, pain and depression. Publications on current treatments reported on six main types of therapy: intravenous immunoglobulins, subcutaneous immunoglobulins, corticosteroids, plasma exchange, immunosuppressants, and immunomodulators. Treatments may be burdensome, due to adverse events and reduced independence caused by treatment administration setting. In Germany, UK, France, and the US, CIDP economic burden was driven by direct costs of treatment and hospitalisation. CIDP was associated with indirect costs driven by impaired productivity. Conclusions: This first systematic review of CIDP burden of illness demonstrates the high physical and psychosocial burden of this rare disease. Future research is required to fully characterise the burden of CIDP, and to understand how appropriate treatment can mitigate burden for patients and healthcare systems.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/269630
https://dx.doi.org/urn:doi:10.1007/s00415-020-09998-8
url https://ddd.uab.cat/record/269630
https://dx.doi.org/urn:doi:10.1007/s00415-020-09998-8
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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