Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women

Little is known about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women >30 years of age. This information is needed to assess the impact of HPV vaccines and consider new screening strat...

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Autores: Muñoz, Nubia, Hernandez-Suarez, G., Méndez, F., Molano, Monica, Posso, H., Moreno Aguado, Víctor, Murillo, R., Ronderos, M., Meijer, Chris J. L. M., Muñoz, Á., INC HPV Study Group
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/120856
Acesso em linha:https://hdl.handle.net/2445/120856
Access Level:acceso abierto
Palavra-chave:Papil·lomavirus
Vacuna del papil·lomavirus
Coll uterí
Tumors
Factors de risc en les malalties
Dones
Colòmbia
Papillomaviruses
Papillomavirus vaccines
Cervix uteri
Risk factors in diseases
Women
Colombia
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network_name_str España
repository_id_str
spelling Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian womenMuñoz, NubiaHernandez-Suarez, G.Méndez, F.Molano, MonicaPosso, H.Moreno Aguado, VíctorMurillo, R.Ronderos, M.Meijer, Chris J. L. M.Muñoz, Á.INC HPV Study GroupPapil·lomavirusVacuna del papil·lomavirusColl uteríTumorsFactors de risc en les malaltiesDonesColòmbiaPapillomavirusesPapillomavirus vaccinesCervix uteriTumorsRisk factors in diseasesWomenColombiaLittle is known about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women >30 years of age. This information is needed to assess the impact of HPV vaccines and consider new screening strategies. A cohort of 1728 women 15-85 years old with normal cytology at baseline was followed every 6 months for an average of 9 years. Women with squamous intraepithelial lesions were referred for biopsy and treatment. The Kaplan-Meier method was used to estimate the median duration of infection and Cox regression analysis was undertaken to assess determinants of clearance and risk of CIN2/3 associated with HPV persistence. No difference in the likelihood of clearance was observed by HPV type or woman's age, with the exception of lower clearance for HPV16 infection in women under 30 years of age. Viral load was inversely associated with clearance. In conclusion, viral load is the main determinant of persistence, and persistence of HPV16 infections carry a higher risk of CIN2/3.Cancer Research UK2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/120856Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/sj.bjc.6604972British Journal of Cancer, 2009, vol. 100, num. 7, p. 1184-1190https://doi.org/10.1038/sj.bjc.6604972cc-by-nc-sa (c) Muñoz, N. et al., 2009http://creativecommons.org/licenses/by-nc-sa/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1208562026-05-27T06:46:51Z
dc.title.none.fl_str_mv Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
title Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
spellingShingle Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
Muñoz, Nubia
Papil·lomavirus
Vacuna del papil·lomavirus
Coll uterí
Tumors
Factors de risc en les malalties
Dones
Colòmbia
Papillomaviruses
Papillomavirus vaccines
Cervix uteri
Tumors
Risk factors in diseases
Women
Colombia
title_short Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
title_full Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
title_fullStr Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
title_full_unstemmed Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
title_sort Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
dc.creator.none.fl_str_mv Muñoz, Nubia
Hernandez-Suarez, G.
Méndez, F.
Molano, Monica
Posso, H.
Moreno Aguado, Víctor
Murillo, R.
Ronderos, M.
Meijer, Chris J. L. M.
Muñoz, Á.
INC HPV Study Group
author Muñoz, Nubia
author_facet Muñoz, Nubia
Hernandez-Suarez, G.
Méndez, F.
Molano, Monica
Posso, H.
Moreno Aguado, Víctor
Murillo, R.
Ronderos, M.
Meijer, Chris J. L. M.
Muñoz, Á.
INC HPV Study Group
author_role author
author2 Hernandez-Suarez, G.
Méndez, F.
Molano, Monica
Posso, H.
Moreno Aguado, Víctor
Murillo, R.
Ronderos, M.
Meijer, Chris J. L. M.
Muñoz, Á.
INC HPV Study Group
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Papil·lomavirus
Vacuna del papil·lomavirus
Coll uterí
Tumors
Factors de risc en les malalties
Dones
Colòmbia
Papillomaviruses
Papillomavirus vaccines
Cervix uteri
Tumors
Risk factors in diseases
Women
Colombia
topic Papil·lomavirus
Vacuna del papil·lomavirus
Coll uterí
Tumors
Factors de risc en les malalties
Dones
Colòmbia
Papillomaviruses
Papillomavirus vaccines
Cervix uteri
Tumors
Risk factors in diseases
Women
Colombia
description Little is known about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women >30 years of age. This information is needed to assess the impact of HPV vaccines and consider new screening strategies. A cohort of 1728 women 15-85 years old with normal cytology at baseline was followed every 6 months for an average of 9 years. Women with squamous intraepithelial lesions were referred for biopsy and treatment. The Kaplan-Meier method was used to estimate the median duration of infection and Cox regression analysis was undertaken to assess determinants of clearance and risk of CIN2/3 associated with HPV persistence. No difference in the likelihood of clearance was observed by HPV type or woman's age, with the exception of lower clearance for HPV16 infection in women under 30 years of age. Viral load was inversely associated with clearance. In conclusion, viral load is the main determinant of persistence, and persistence of HPV16 infections carry a higher risk of CIN2/3.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/120856
url https://hdl.handle.net/2445/120856
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/sj.bjc.6604972
British Journal of Cancer, 2009, vol. 100, num. 7, p. 1184-1190
https://doi.org/10.1038/sj.bjc.6604972
dc.rights.none.fl_str_mv cc-by-nc-sa (c) Muñoz, N. et al., 2009
http://creativecommons.org/licenses/by-nc-sa/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-sa (c) Muñoz, N. et al., 2009
http://creativecommons.org/licenses/by-nc-sa/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cancer Research UK
publisher.none.fl_str_mv Cancer Research UK
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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