Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19
Unraveling the long-term kinetics of antibodies to SARS-CoV-2 and the individual characteristics influencing it, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential to understand protective immunity to COVID-19 and devise effective surveil...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/225440 |
| Acesso em linha: | https://hdl.handle.net/2445/225440 |
| Access Level: | acceso abierto |
| Palavra-chave: | SARS-CoV-2 Pandèmia de COVID-19, 2020-2023 COVID-19 Pandemic, 2020- 2023 |
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Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19Ortega, NataliaRibes, MartaVidal, MartaRubio, RocíoAguilar, RuthWilliams, SarahBarrios, DianaAlonso, SelenaHernández-Luis, PabloMitchell, Robert A.Jairoce, ChenjeraiCruz, AngelineJiménez, AlfonsSantano, RebecaMéndez, SusanaLamoglia Puig, MontserratRosell, NeusLlupià García, AnnaPuyol, LauraChi, JordiRodrigo-Melero, NataliaParras, DanielSerra, PauPradenas Saavedra, EdwardsTrinité, BenjaminBlanco, JuliàMayor Aparicio, Alfredo GabrielBarroso, SoniaVarela, PilarVilella, AnnaTrilla Garcia, Antonio De PaduaSantamaria, PereCarolis, CarloTortajada, MartaIzquierdo Lázaro, LuisAngulo Aguado, AnaEngel Rocamora, PabloGarcia-Basteiro, Alberto LMoncunill Piñas, GemmaDobaño, Carlota, 1969-SARS-CoV-2Pandèmia de COVID-19, 2020-2023SARS-CoV-2COVID-19 Pandemic, 2020- 2023Unraveling the long-term kinetics of antibodies to SARS-CoV-2 and the individual characteristics influencing it, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential to understand protective immunity to COVID-19 and devise effective surveillance strategies. IgM, IgA and IgG levels against six SARS-CoV-2 antigens and the nucleocapsid antigen of the four HCoV (229E, NL63, OC43 and HKU1) were quantified by Luminex, and antibody neutralization capacity was assessed by flow cytometry, in a cohort of health care workers followed up to 7 months (N = 578). Seroprevalence increases over time from 13.5% (month 0) and 15.6% (month 1) to 16.4% (month 6). Levels of antibodies, including those with neutralizing capacity, are stable over time, except IgG to nucleocapsid antigen and IgM levels that wane. After the peak response, anti-spike antibody levels increase from ~150 days post-symptom onset in all individuals (73% for IgG), in the absence of any evidence of re-exposure. IgG and IgA to HCoV are significantly higher in asymptomatic than symptomatic seropositive individuals. Thus, pre-existing cross-reactive HCoVs antibodies could have a protective effect against SARS-CoV-2 infection and COVID-19 disease.Nature Publishing Group2026202620212026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/225440Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41467-021-24979-9Nature Communications, 2021, vol. 12, num.1https://doi.org/10.1038/s41467-021-24979-9cc-by (c) Ortega, N. et al., 2021http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2254402026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19 |
| title |
Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19 |
| spellingShingle |
Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19 Ortega, Natalia SARS-CoV-2 Pandèmia de COVID-19, 2020-2023 SARS-CoV-2 COVID-19 Pandemic, 2020- 2023 |
| title_short |
Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19 |
| title_full |
Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19 |
| title_fullStr |
Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19 |
| title_full_unstemmed |
Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19 |
| title_sort |
Seven-month kinetics of SARS-CoV-2 antibodies and protective role of pre-existing antibodies to seasonal human coronaviruses on COVID-19 |
| dc.creator.none.fl_str_mv |
Ortega, Natalia Ribes, Marta Vidal, Marta Rubio, Rocío Aguilar, Ruth Williams, Sarah Barrios, Diana Alonso, Selena Hernández-Luis, Pablo Mitchell, Robert A. Jairoce, Chenjerai Cruz, Angeline Jiménez, Alfons Santano, Rebeca Méndez, Susana Lamoglia Puig, Montserrat Rosell, Neus Llupià García, Anna Puyol, Laura Chi, Jordi Rodrigo-Melero, Natalia Parras, Daniel Serra, Pau Pradenas Saavedra, Edwards Trinité, Benjamin Blanco, Julià Mayor Aparicio, Alfredo Gabriel Barroso, Sonia Varela, Pilar Vilella, Anna Trilla Garcia, Antonio De Padua Santamaria, Pere Carolis, Carlo Tortajada, Marta Izquierdo Lázaro, Luis Angulo Aguado, Ana Engel Rocamora, Pablo Garcia-Basteiro, Alberto L Moncunill Piñas, Gemma Dobaño, Carlota, 1969- |
| author |
Ortega, Natalia |
| author_facet |
Ortega, Natalia Ribes, Marta Vidal, Marta Rubio, Rocío Aguilar, Ruth Williams, Sarah Barrios, Diana Alonso, Selena Hernández-Luis, Pablo Mitchell, Robert A. Jairoce, Chenjerai Cruz, Angeline Jiménez, Alfons Santano, Rebeca Méndez, Susana Lamoglia Puig, Montserrat Rosell, Neus Llupià García, Anna Puyol, Laura Chi, Jordi Rodrigo-Melero, Natalia Parras, Daniel Serra, Pau Pradenas Saavedra, Edwards Trinité, Benjamin Blanco, Julià Mayor Aparicio, Alfredo Gabriel Barroso, Sonia Varela, Pilar Vilella, Anna Trilla Garcia, Antonio De Padua Santamaria, Pere Carolis, Carlo Tortajada, Marta Izquierdo Lázaro, Luis Angulo Aguado, Ana Engel Rocamora, Pablo Garcia-Basteiro, Alberto L Moncunill Piñas, Gemma Dobaño, Carlota, 1969- |
| author_role |
author |
| author2 |
Ribes, Marta Vidal, Marta Rubio, Rocío Aguilar, Ruth Williams, Sarah Barrios, Diana Alonso, Selena Hernández-Luis, Pablo Mitchell, Robert A. Jairoce, Chenjerai Cruz, Angeline Jiménez, Alfons Santano, Rebeca Méndez, Susana Lamoglia Puig, Montserrat Rosell, Neus Llupià García, Anna Puyol, Laura Chi, Jordi Rodrigo-Melero, Natalia Parras, Daniel Serra, Pau Pradenas Saavedra, Edwards Trinité, Benjamin Blanco, Julià Mayor Aparicio, Alfredo Gabriel Barroso, Sonia Varela, Pilar Vilella, Anna Trilla Garcia, Antonio De Padua Santamaria, Pere Carolis, Carlo Tortajada, Marta Izquierdo Lázaro, Luis Angulo Aguado, Ana Engel Rocamora, Pablo Garcia-Basteiro, Alberto L Moncunill Piñas, Gemma Dobaño, Carlota, 1969- |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
SARS-CoV-2 Pandèmia de COVID-19, 2020-2023 SARS-CoV-2 COVID-19 Pandemic, 2020- 2023 |
| topic |
SARS-CoV-2 Pandèmia de COVID-19, 2020-2023 SARS-CoV-2 COVID-19 Pandemic, 2020- 2023 |
| description |
Unraveling the long-term kinetics of antibodies to SARS-CoV-2 and the individual characteristics influencing it, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential to understand protective immunity to COVID-19 and devise effective surveillance strategies. IgM, IgA and IgG levels against six SARS-CoV-2 antigens and the nucleocapsid antigen of the four HCoV (229E, NL63, OC43 and HKU1) were quantified by Luminex, and antibody neutralization capacity was assessed by flow cytometry, in a cohort of health care workers followed up to 7 months (N = 578). Seroprevalence increases over time from 13.5% (month 0) and 15.6% (month 1) to 16.4% (month 6). Levels of antibodies, including those with neutralizing capacity, are stable over time, except IgG to nucleocapsid antigen and IgM levels that wane. After the peak response, anti-spike antibody levels increase from ~150 days post-symptom onset in all individuals (73% for IgG), in the absence of any evidence of re-exposure. IgG and IgA to HCoV are significantly higher in asymptomatic than symptomatic seropositive individuals. Thus, pre-existing cross-reactive HCoVs antibodies could have a protective effect against SARS-CoV-2 infection and COVID-19 disease. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2026 2026 2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/225440 |
| url |
https://hdl.handle.net/2445/225440 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1038/s41467-021-24979-9 Nature Communications, 2021, vol. 12, num.1 https://doi.org/10.1038/s41467-021-24979-9 |
| dc.rights.none.fl_str_mv |
cc-by (c) Ortega, N. et al., 2021 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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cc-by (c) Ortega, N. et al., 2021 http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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10 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Nature Publishing Group |
| publisher.none.fl_str_mv |
Nature Publishing Group |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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