TNFAIP3, TNIP1, and MyD88 polymorphisms predict septic-shock-related death in patients who underwent major surgery

Producción Científica

Detalles Bibliográficos
Autores: Jiménez Sousa, María Ángeles, Fadrique, Alejandra, Liu, Pilar, Fernández Rodríguez, Amanda, Lorenzo López, Mario, Gómez Sánchez, Esther, Gómez Sanz, Alicia, Heredia Rodríguez, María, Gómez Pesquera, Estefanía, Marti­nez, Isidoro, Tamayo Gómez, Eduardo, Resino, Salvador
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/56433
Acceso en línea:https://doi.org/10.3390/jcm8030283
https://uvadoc.uva.es/handle/10324/56433
Access Level:acceso abierto
Palabra clave:Major surgery
Cirugía mayor
Septic shock
Shock séptico
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spelling TNFAIP3, TNIP1, and MyD88 polymorphisms predict septic-shock-related death in patients who underwent major surgeryJiménez Sousa, María ÁngelesFadrique, AlejandraLiu, PilarFernández Rodríguez, AmandaLorenzo López, MarioGómez Sánchez, EstherGómez Sanz, AliciaHeredia Rodríguez, MaríaGómez Pesquera, EstefaníaMarti­nez, IsidoroTamayo Gómez, EduardoResino, SalvadorMajor surgeryCirugía mayorSeptic shockShock sépticoProducción CientíficaBackground: In many immune-related diseases, inflammatory responses and several clinical outcomes are related to increased NF-κB activity. We aimed to evaluate whether SNPs related to the NF-κB signaling pathway are associated with higher susceptibility to infection, septic shock, and septic-shock-related death in European patients who underwent major surgery. Methods: We performed a case-control study on 184 patients with septic shock and 212 with systemic inflammatory response syndrome, and a longitudinal substudy on septic shock patients. Thirty-three SNPs within genes belonging to or regulating the NF-κB signaling pathway were genotyped by Agena Bioscience’s MassARRAY platform. Results: No significant results were found for susceptibility to infection and septic shock in the multivariate analysis after adjusting for multiple comparisons. Regarding septic-shock-related death, patients with TNFAIP3 rs6920220 AA, TNIP1 rs73272842 AA, TNIP1 rs3792783 GG, and TNIP1 rs7708392 CC genotypes had the highest risk of septic-shock-related death in the first 28 and 90 days. Also, the MyD88 rs7744 GG genotype was associated with a higher risk of death during the first 90 days. Haplotype analysis shows us that patients with the TNIP1 GAG haplotype (composed of rs73272842, rs3792783, and rs7708392) had a lower risk of death in the first 28 days and the TNIP1 AGC haplotype was associated with a higher risk of death in the first 90 days. Conclusions: The SNPs in the genes TNFAIP3, TNIP1, and MyD88 were linked to the risk of septic-shock-related death in patients who underwent major surgery.Instituto de Salud Carlos III - Fondo Europeo de Desarrollo Regional (grant PT13/0001)MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/jcm8030283https://uvadoc.uva.es/handle/10324/56433reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/2077-0383/8/3/283info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/564332026-06-13T12:44:47Z
dc.title.none.fl_str_mv TNFAIP3, TNIP1, and MyD88 polymorphisms predict septic-shock-related death in patients who underwent major surgery
title TNFAIP3, TNIP1, and MyD88 polymorphisms predict septic-shock-related death in patients who underwent major surgery
spellingShingle TNFAIP3, TNIP1, and MyD88 polymorphisms predict septic-shock-related death in patients who underwent major surgery
Jiménez Sousa, María Ángeles
Major surgery
Cirugía mayor
Septic shock
Shock séptico
title_short TNFAIP3, TNIP1, and MyD88 polymorphisms predict septic-shock-related death in patients who underwent major surgery
title_full TNFAIP3, TNIP1, and MyD88 polymorphisms predict septic-shock-related death in patients who underwent major surgery
title_fullStr TNFAIP3, TNIP1, and MyD88 polymorphisms predict septic-shock-related death in patients who underwent major surgery
title_full_unstemmed TNFAIP3, TNIP1, and MyD88 polymorphisms predict septic-shock-related death in patients who underwent major surgery
title_sort TNFAIP3, TNIP1, and MyD88 polymorphisms predict septic-shock-related death in patients who underwent major surgery
dc.creator.none.fl_str_mv Jiménez Sousa, María Ángeles
Fadrique, Alejandra
Liu, Pilar
Fernández Rodríguez, Amanda
Lorenzo López, Mario
Gómez Sánchez, Esther
Gómez Sanz, Alicia
Heredia Rodríguez, María
Gómez Pesquera, Estefanía
Marti­nez, Isidoro
Tamayo Gómez, Eduardo
Resino, Salvador
author Jiménez Sousa, María Ángeles
author_facet Jiménez Sousa, María Ángeles
Fadrique, Alejandra
Liu, Pilar
Fernández Rodríguez, Amanda
Lorenzo López, Mario
Gómez Sánchez, Esther
Gómez Sanz, Alicia
Heredia Rodríguez, María
Gómez Pesquera, Estefanía
Marti­nez, Isidoro
Tamayo Gómez, Eduardo
Resino, Salvador
author_role author
author2 Fadrique, Alejandra
Liu, Pilar
Fernández Rodríguez, Amanda
Lorenzo López, Mario
Gómez Sánchez, Esther
Gómez Sanz, Alicia
Heredia Rodríguez, María
Gómez Pesquera, Estefanía
Marti­nez, Isidoro
Tamayo Gómez, Eduardo
Resino, Salvador
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Major surgery
Cirugía mayor
Septic shock
Shock séptico
topic Major surgery
Cirugía mayor
Septic shock
Shock séptico
description Producción Científica
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm8030283
https://uvadoc.uva.es/handle/10324/56433
url https://doi.org/10.3390/jcm8030283
https://uvadoc.uva.es/handle/10324/56433
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2077-0383/8/3/283
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
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