Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

HIV infections; Restriction factors

Detalles Bibliográficos
Autores: Kobayashi-Ishihara, Mie, Frazão Smutná, Katarína, Alonso, Florencia E., Argilaguet, Jordi, Esteve-Codina, Anna, Geiger, Kerstin, Genescà Ferrer, Meritxell, Grau Exposito, Judith, Buzon, Maria Jose
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/9537
Acceso en línea:https://hdl.handle.net/11351/9537
http://hdl.handle.net/11351/9537
Access Level:acceso abierto
Palabra clave:VIH (Virus)
Lentivirus
RNA
PHENOMENA AND PROCESSES::Microbiological Phenomena::Virus Physiological Phenomena::Virus Latency
ORGANISMS::Viruses::RNA Viruses::Retroviridae::Lentivirus::Lentiviruses, Primate::HIV::HIV-1
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Viral
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos de los virus::latencia viral
ORGANISMOS::virus::virus ARN::Retroviridae::Lentivirus::Lentivirus de los primates::VIH::VIH-1
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ARN::ARN vírico
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network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
title Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
spellingShingle Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
Kobayashi-Ishihara, Mie
VIH (Virus)
Lentivirus
RNA
PHENOMENA AND PROCESSES::Microbiological Phenomena::Virus Physiological Phenomena::Virus Latency
ORGANISMS::Viruses::RNA Viruses::Retroviridae::Lentivirus::Lentiviruses, Primate::HIV::HIV-1
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Viral
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos de los virus::latencia viral
ORGANISMOS::virus::virus ARN::Retroviridae::Lentivirus::Lentivirus de los primates::VIH::VIH-1
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ARN::ARN vírico
title_short Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
title_full Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
title_fullStr Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
title_full_unstemmed Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
title_sort Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
dc.creator.none.fl_str_mv Kobayashi-Ishihara, Mie
Frazão Smutná, Katarína
Alonso, Florencia E.
Argilaguet, Jordi
Esteve-Codina, Anna
Geiger, Kerstin
Genescà Ferrer, Meritxell
Grau Exposito, Judith
Buzon, Maria Jose
author Kobayashi-Ishihara, Mie
author_facet Kobayashi-Ishihara, Mie
Frazão Smutná, Katarína
Alonso, Florencia E.
Argilaguet, Jordi
Esteve-Codina, Anna
Geiger, Kerstin
Genescà Ferrer, Meritxell
Grau Exposito, Judith
Buzon, Maria Jose
author_role author
author2 Frazão Smutná, Katarína
Alonso, Florencia E.
Argilaguet, Jordi
Esteve-Codina, Anna
Geiger, Kerstin
Genescà Ferrer, Meritxell
Grau Exposito, Judith
Buzon, Maria Jose
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Kobayashi-Ishihara M] Infection Biology Group, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan. [Frazão Smutná K, Alonso FE, Geiger K] Infection Biology Group, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain. [Argilaguet J] Infection Biology Group, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Unitat mixta d’Investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. IRTA. Programa de Sanitat Animal. Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. [Esteve-Codina A] Centro Nacional de Análisis Genómico (CNAG-CRG), Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain. [Genescà M, Grau-Expósito J, Buzon MJ] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv VIH (Virus)
Lentivirus
RNA
PHENOMENA AND PROCESSES::Microbiological Phenomena::Virus Physiological Phenomena::Virus Latency
ORGANISMS::Viruses::RNA Viruses::Retroviridae::Lentivirus::Lentiviruses, Primate::HIV::HIV-1
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Viral
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos de los virus::latencia viral
ORGANISMOS::virus::virus ARN::Retroviridae::Lentivirus::Lentivirus de los primates::VIH::VIH-1
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ARN::ARN vírico
topic VIH (Virus)
Lentivirus
RNA
PHENOMENA AND PROCESSES::Microbiological Phenomena::Virus Physiological Phenomena::Virus Latency
ORGANISMS::Viruses::RNA Viruses::Retroviridae::Lentivirus::Lentiviruses, Primate::HIV::HIV-1
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Viral
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos de los virus::latencia viral
ORGANISMOS::virus::virus ARN::Retroviridae::Lentivirus::Lentivirus de los primates::VIH::VIH-1
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ARN::ARN vírico
description HIV infections; Restriction factors
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/9537
http://hdl.handle.net/11351/9537
url https://hdl.handle.net/11351/9537
http://hdl.handle.net/11351/9537
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Communications Biology;6
https://doi.org/10.1038/s42003-023-04841-y
info:eu-repo/grantAgreement/ES/PE2017-2020/RTI2018-101082-B-I00
info:eu-repo/grantAgreement/ES/PEICTI2021-2023/PID2021-123321OB-I00
info:eu-repo/grantAgreement/ES/PE2017-2020/CP17%2F00179
info:eu-repo/grantAgreement/ES/PEICTI2021-2023/CPII22%2F00005
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Portfolio
publisher.none.fl_str_mv Nature Portfolio
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cellsKobayashi-Ishihara, MieFrazão Smutná, KatarínaAlonso, Florencia E.Argilaguet, JordiEsteve-Codina, AnnaGeiger, KerstinGenescà Ferrer, MeritxellGrau Exposito, JudithBuzon, Maria JoseVIH (Virus)LentivirusRNAPHENOMENA AND PROCESSES::Microbiological Phenomena::Virus Physiological Phenomena::Virus LatencyORGANISMS::Viruses::RNA Viruses::Retroviridae::Lentivirus::Lentiviruses, Primate::HIV::HIV-1CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, ViralFENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos de los virus::latencia viralORGANISMOS::virus::virus ARN::Retroviridae::Lentivirus::Lentivirus de los primates::VIH::VIH-1COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ARN::ARN víricoHIV infections; Restriction factorsInfecciones por VIH; Factores de restricciónInfeccions pel VIH; Factors de restriccióLatency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood. Here we describe the Schlafen 12 protein (SLFN12) as an HIV-1 restriction factor that establishes a post-transcriptional block in HIV-1-infected cells and thereby inhibits HIV-1 replication and virus reactivation from latently infected cells. The inhibitory activity is dependent on the HIV-1 codon usage and on the SLFN12 RNase active sites. Within HIV-1-infected individuals, SLFN12 expression in PBMCs correlated with HIV-1 plasma viral loads and proviral loads suggesting a link with the general activation of the immune system. Using an RNA FISH-Flow HIV-1 reactivation assay, we demonstrate that SLFN12 expression is enriched in infected cells positive for HIV-1 transcripts but negative for HIV-1 proteins. Thus, codon-usage dependent translation inhibition of HIV-1 proteins participates in HIV-1 latency and can restrict the amount of virus release after latency reversal.This work was supported by following grants: M.K.I., JSPS Oversea Research Fellowship and Takeda Science Foundation; A.E.C., PT17/0009/0019 (ISCIII/MINECO and FEDER); M.J.B., RTI2018-101082-B-I00 and PID2021-123321OB-I00 [MINECO/FEDER]), and the Miguel Servet program by ISCIII (CP17/00179 and CPII22/00005); C.B., M.R.R., C.D.C., European Union’s Horizon 2020 research and innovation program under grant agreement 681137-EAVI2020 and NIH grant P01-AI131568; J.D., the Spanish Ministry of Science and Innovation (PID2019106959RB-I00/AEI/10.13039/501100011033); A.M., the Spanish Ministry of Science and Innovation (PID2019-106323RB-I00 AEI//10.13039/501100011033) and the institutional “María de Maeztu” Programme for Units of Excellence in R&D (CEX2018-000792-M).Nature PortfolioInstitut Català de la Salut[Kobayashi-Ishihara M] Infection Biology Group, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan. [Frazão Smutná K, Alonso FE, Geiger K] Infection Biology Group, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain. [Argilaguet J] Infection Biology Group, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Unitat mixta d’Investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. IRTA. Programa de Sanitat Animal. Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. [Esteve-Codina A] Centro Nacional de Análisis Genómico (CNAG-CRG), Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain. [Genescà M, Grau-Expósito J, Buzon MJ] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/9537http://hdl.handle.net/11351/9537Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCommunications Biology;6https://doi.org/10.1038/s42003-023-04841-yinfo:eu-repo/grantAgreement/ES/PE2017-2020/RTI2018-101082-B-I00info:eu-repo/grantAgreement/ES/PEICTI2021-2023/PID2021-123321OB-I00info:eu-repo/grantAgreement/ES/PE2017-2020/CP17%2F00179info:eu-repo/grantAgreement/ES/PEICTI2021-2023/CPII22%2F00005Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/95372026-05-29T05:05:01Z
score 15,811543

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