Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.

382 p.

Bibliographic Details
Author: Pérez del Palomar Asín, Blanca
Format: doctoral thesis
Publication Date:2019
Country:España
Institution:Universidad del País Vasco
Repository:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/45007
Online Access:http://hdl.handle.net/10810/45007
Access Level:Open access
Keyword:psychopharmacology
psicofarmacología
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.Pérez del Palomar Asín, Blancapsychopharmacologypsicofarmacología382 p.Schizophrenia is a multi multifaceted, heterogeneous, chronic and debilitating disorder triggered by a series of interacting genetic, developmental and environmental factors. Cognitive impairment is considered a core feature of this disorder and highly dependent on the correct functioning of the prefrontal cortex, however, current antipsychotics lack efficacy for treating this condition. Prenatal exposure to infection is contemplated as one the most significant environmental risk factors for developing schizophrenia in the offspring. In this context, maternal immune activation animal models produce neurochemical and behavioral alterations considered relevant for the study of schizophrenia dysfunctions.The first part of this thesis consists of a neurochemical and behavioral characterization of an animal model of cognitive impairment associated with schizophrenia by the administration of the immunostimulant agent Poly (I:C). The second part involves the study of the effects of ¿2-adrenoceptor compounds on cognitive performance in the offspring. Finally, selective targeting of the locus coeruleus-prefrontal cortex circuit by different optogenetic approaches was performed.The Poly (I:C) animal model shows a catecholaminergic hypofunction in the prefrontal cortex with marked cognitive deficits, which are reversed by the administration of 2A-adrenoceptor agonist guanfacine and the 2C-adrenoceptor antagonist MK-912.These results support the important role of the noradrenergic system in the prefrontal cortex-dependent cognitive functions and the Poly (I:C) animal model as a promising translational model of cognitive impairment associated with schizophrenia.Meana Martínez, José JavierOrtega Calvo, Jorge2020202020192019info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10810/45007reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/semantics/openAccess(c)2019 BLANCA PEREZ DEL PALOMAR ASINoai:addi.ehu.eus:10810/450072026-06-18T09:23:17Z
dc.title.none.fl_str_mv Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
title Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
spellingShingle Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
Pérez del Palomar Asín, Blanca
psychopharmacology
psicofarmacología
title_short Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
title_full Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
title_fullStr Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
title_full_unstemmed Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
title_sort Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
dc.creator.none.fl_str_mv Pérez del Palomar Asín, Blanca
author Pérez del Palomar Asín, Blanca
author_facet Pérez del Palomar Asín, Blanca
author_role author
dc.contributor.none.fl_str_mv Meana Martínez, José Javier
Ortega Calvo, Jorge
dc.subject.none.fl_str_mv psychopharmacology
psicofarmacología
topic psychopharmacology
psicofarmacología
description 382 p.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/45007
url http://hdl.handle.net/10810/45007
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
(c)2019 BLANCA PEREZ DEL PALOMAR ASIN
eu_rights_str_mv openAccess
rights_invalid_str_mv (c)2019 BLANCA PEREZ DEL PALOMAR ASIN
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425674503061504
score 15,300719

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