ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay

Data de publicació electrònica: 09-06-2025

Detalles Bibliográficos
Autores: Poliński, Patryk, Miret-Cuesta, Marta, Irimia Martínez, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/70977
Acceso en línea:http://hdl.handle.net/10230/70977
http://dx.doi.org/10.1002/cm.22051
Access Level:acceso abierto
Palabra clave:ARC
Alternative splicing
Formin
Synapse
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spelling ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK InterplayPoliński, PatrykMiret-Cuesta, MartaIrimia Martínez, ManuelARCAlternative splicingForminSynapseData de publicació electrònica: 09-06-2025Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural-specific microexon in DAAM1 in modulating actin's role in synaptic processes. This article discusses the impact of this microexon on actin polymerization, the RHOA/ROCK signaling pathway, and cognitive functions. Furthermore, we present new results that reveal a more complex scenario involving the upregulation of the activity-regulated cytoskeleton-associated protein (ARC) protein in DAAM1 microexon KO models, which may further affect synaptic function and cognition.The research has been funded by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (ERCCoG-LS2-101002275 to M.I.), Spanish Ministry of Science and Innovation (PID2020-115040GB-I00 to M.I.), the European Union's Horizon 2020 research and innovation program under grant agreements No. 721890 to P.P.Wiley202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/70977http://dx.doi.org/10.1002/cm.22051http://hdl.handle.net/10230/70977reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCytoskeleton (Hoboken). 2025 Jun 9info:eu-repo/grantAgreement/EC/H2020/101002275info:eu-repo/grantAgreement/ES/2PE/PID2020-115040GB-I00info:eu-repo/grantAgreement/EC/H2020/721890© 2025 The Author(s). Cytoskeleton published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/709772026-05-29T05:05:01Z
dc.title.none.fl_str_mv ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
title ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
spellingShingle ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
Poliński, Patryk
ARC
Alternative splicing
Formin
Synapse
title_short ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
title_full ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
title_fullStr ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
title_full_unstemmed ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
title_sort ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
dc.creator.none.fl_str_mv Poliński, Patryk
Miret-Cuesta, Marta
Irimia Martínez, Manuel
author Poliński, Patryk
author_facet Poliński, Patryk
Miret-Cuesta, Marta
Irimia Martínez, Manuel
author_role author
author2 Miret-Cuesta, Marta
Irimia Martínez, Manuel
author2_role author
author
dc.subject.none.fl_str_mv ARC
Alternative splicing
Formin
Synapse
topic ARC
Alternative splicing
Formin
Synapse
description Data de publicació electrònica: 09-06-2025
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/70977
http://dx.doi.org/10.1002/cm.22051
http://hdl.handle.net/10230/70977
url http://hdl.handle.net/10230/70977
http://dx.doi.org/10.1002/cm.22051
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cytoskeleton (Hoboken). 2025 Jun 9
info:eu-repo/grantAgreement/EC/H2020/101002275
info:eu-repo/grantAgreement/ES/2PE/PID2020-115040GB-I00
info:eu-repo/grantAgreement/EC/H2020/721890
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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