Bovine host genome acts on rumen microbiome function linked to methane emissions

[EN] Our study provides substantial evidence that the host genome affects the comprehensive function of the microbiome in the rumen of bovines. Of 1,107/225/1,141 rumen microbial genera/metagenome assembled uncultured genomes (RUGs)/genes identified from whole metagenomics sequencing, 194/14/337 had...

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Autores: Martínez-Álvaro, Marina|||0000-0003-2295-5839, Auffret, Marc D., Duthie, Carol-Anne, Dewhurst, Richard J., Cleveland, Matthew A., Watson, Mick, Roehe, Rainer
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/232548
Acceso en línea:https://riunet.upv.es/handle/10251/232548
Access Level:acceso abierto
Palabra clave:Rumen microbiome
Host genomic control
Methane emissions
Bovine genetics
Microbiome heritability
Greenhouse gas mitigation
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spelling Bovine host genome acts on rumen microbiome function linked to methane emissionsMartínez-Álvaro, Marina|||0000-0003-2295-5839Auffret, Marc D.Duthie, Carol-AnneDewhurst, Richard J.Cleveland, Matthew A.Watson, MickRoehe, RainerRumen microbiomeHost genomic controlMethane emissionsBovine geneticsMicrobiome heritabilityGreenhouse gas mitigation[EN] Our study provides substantial evidence that the host genome affects the comprehensive function of the microbiome in the rumen of bovines. Of 1,107/225/1,141 rumen microbial genera/metagenome assembled uncultured genomes (RUGs)/genes identified from whole metagenomics sequencing, 194/14/337 had significant host genomic effects (heritabilities ranging from 0.13 to 0.61), revealing that substantial variation of the microbiome is under host genomic control. We found 29/22/115 microbial genera/RUGs/genes host-genomically correlated (|0.59| to |0.93|) with emissions of the potent greenhouse gas methane (CH4), highlighting the strength of a common host genomic control of specific microbial processes and CH4. Only one of these microbial genes was directly involved in methanogenesis (cofG), whereas others were involved in providing substrates for archaea (e.g. bcd and pccB), important microbial interspecies communication mechanisms (ABC.PE.P), host-microbiome interaction (TSTA3) and genetic information processes (RP-L35). In our population, selection based on abundances of the 30 most informative microbial genes provided a mitigation potential of 17% of mean CH4 emissions per generation, which is higher than for selection based on measured CH4 using respiration chambers (13%), indicating the high potential of microbiome-driven breeding to cumulatively reduce CH4 emissions and mitigate climate change.Springer NatureDepartamento de Ciencia AnimalInstituto Universitario de Ciencia y Tecnología AnimalEscuela Técnica Superior de Ingeniería Agronómica y del Medio NaturalRepositorio Institucional de la Universitat Politècnica de València Riunet20222022-04-12journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/232548reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2325482026-06-13T07:49:27Z
dc.title.none.fl_str_mv Bovine host genome acts on rumen microbiome function linked to methane emissions
title Bovine host genome acts on rumen microbiome function linked to methane emissions
spellingShingle Bovine host genome acts on rumen microbiome function linked to methane emissions
Martínez-Álvaro, Marina|||0000-0003-2295-5839
Rumen microbiome
Host genomic control
Methane emissions
Bovine genetics
Microbiome heritability
Greenhouse gas mitigation
title_short Bovine host genome acts on rumen microbiome function linked to methane emissions
title_full Bovine host genome acts on rumen microbiome function linked to methane emissions
title_fullStr Bovine host genome acts on rumen microbiome function linked to methane emissions
title_full_unstemmed Bovine host genome acts on rumen microbiome function linked to methane emissions
title_sort Bovine host genome acts on rumen microbiome function linked to methane emissions
dc.creator.none.fl_str_mv Martínez-Álvaro, Marina|||0000-0003-2295-5839
Auffret, Marc D.
Duthie, Carol-Anne
Dewhurst, Richard J.
Cleveland, Matthew A.
Watson, Mick
Roehe, Rainer
author Martínez-Álvaro, Marina|||0000-0003-2295-5839
author_facet Martínez-Álvaro, Marina|||0000-0003-2295-5839
Auffret, Marc D.
Duthie, Carol-Anne
Dewhurst, Richard J.
Cleveland, Matthew A.
Watson, Mick
Roehe, Rainer
author_role author
author2 Auffret, Marc D.
Duthie, Carol-Anne
Dewhurst, Richard J.
Cleveland, Matthew A.
Watson, Mick
Roehe, Rainer
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Ciencia Animal
Instituto Universitario de Ciencia y Tecnología Animal
Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Rumen microbiome
Host genomic control
Methane emissions
Bovine genetics
Microbiome heritability
Greenhouse gas mitigation
topic Rumen microbiome
Host genomic control
Methane emissions
Bovine genetics
Microbiome heritability
Greenhouse gas mitigation
description [EN] Our study provides substantial evidence that the host genome affects the comprehensive function of the microbiome in the rumen of bovines. Of 1,107/225/1,141 rumen microbial genera/metagenome assembled uncultured genomes (RUGs)/genes identified from whole metagenomics sequencing, 194/14/337 had significant host genomic effects (heritabilities ranging from 0.13 to 0.61), revealing that substantial variation of the microbiome is under host genomic control. We found 29/22/115 microbial genera/RUGs/genes host-genomically correlated (|0.59| to |0.93|) with emissions of the potent greenhouse gas methane (CH4), highlighting the strength of a common host genomic control of specific microbial processes and CH4. Only one of these microbial genes was directly involved in methanogenesis (cofG), whereas others were involved in providing substrates for archaea (e.g. bcd and pccB), important microbial interspecies communication mechanisms (ABC.PE.P), host-microbiome interaction (TSTA3) and genetic information processes (RP-L35). In our population, selection based on abundances of the 30 most informative microbial genes provided a mitigation potential of 17% of mean CH4 emissions per generation, which is higher than for selection based on measured CH4 using respiration chambers (13%), indicating the high potential of microbiome-driven breeding to cumulatively reduce CH4 emissions and mitigate climate change.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-04-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/232548
url https://riunet.upv.es/handle/10251/232548
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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