Subthalamic stimulation elicits different transient properties of cortical rhythms during open-eyes and closed-eyes resting states

Background: Several studies have emphasized on variations in brain functional features between spontaneous brain activity between the eyes-open (EO) and eyes-closed (EC) resting states, assuming that brain activity is a static phenomenon. Besides, Parkinson’s disease (PD) has been associated with ch...

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Authors: Méndez Bértolo, Constantino José, Sanmartino, Florencia, López-Sosa, Fernando, Cruz-Gómez, Álvaro J., Lozano-Soto, Elena, Espinosa-Rosso, Raúl, Rashid-López, Raúl, González-Rosa, Javier J.
Format: article
Publication Date:2023
Country:España
Institution:Universidad Nacional de Educación a Distancia
Repository:e-spacio (DSpace). Repositorio Institucional de la UNED
Language:Spanish
OAI Identifier:oai:e-spacio.uned.es:20.500.14468/31863
Online Access:https://hdl.handle.net/20.500.14468/31863
Access Level:Open access
Keyword:2490 Neurociencias
Spontaneous EEG activity
Deep brain stimulation
Subthalamic nucleus
Parkinson’s disease
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spelling Subthalamic stimulation elicits different transient properties of cortical rhythms during open-eyes and closed-eyes resting statesMéndez Bértolo, Constantino JoséSanmartino, FlorenciaLópez-Sosa, FernandoCruz-Gómez, Álvaro J.Lozano-Soto, ElenaEspinosa-Rosso, RaúlRashid-López, RaúlGonzález-Rosa, Javier J.2490 NeurocienciasSpontaneous EEG activityDeep brain stimulationSubthalamic nucleusParkinson’s diseaseBackground: Several studies have emphasized on variations in brain functional features between spontaneous brain activity between the eyes-open (EO) and eyes-closed (EC) resting states, assuming that brain activity is a static phenomenon. Besides, Parkinson’s disease (PD) has been associated with characteristic patterns of synchronous oscillatory activity within cortico-basal-ganglia circuits, but the functional relationship between STN-DBS and the brain’s resting state activity is still unclear. The purpose of this study was to investigate the dynamic nature of brain activity in different EO and EC resting conditions and the transient effects on sensorimotor and cortical networks in response to subthalamic stimulation in unmedicated PD patients. Methods: Fifteen unmedicated PD patients treated with bilateral STN-DBS and 17 matched-healthy controls were recruited. Spontaneous electroencephalographic (EEG) activity at rest was recorded during 4 min EC and 4 min EO and during STN-DBS On/Off states in the case of PD patients. Grand average topographical maps were analyzed for extraction of logarithmic spectral power of each EEG frequency band at posterior, central and frontocentral regions. Results: Compared to DBS ‘Off’ state, STN stimulation modulated activity in all frequency bands was unaltered between EC and EO states while dopamine depleted patients power in alpha and theta bands differed. Low and high beta and gamma activity of PD patients in the stimulation OFF condition showed no increases or reductions in comparison with healthy controls while activation in all those frequency bands were modulated by the stimulator state. Conclusions: Our findings may provide insights into the dynamic nature of the resting-state brain activity in PD and suggest that STN-DBS in a dopamine deprived state can selectively regulate the focal character of cortical frequency bands in addition to between EC and EO resting states and particularly for posterior cortical alpha activity, which would rise during PD disease progression.Elseviere-Spacio UNED20262026-02-1620232023-02-1520232023-02-15journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14468/31863reponame:e-spacio (DSpace). Repositorio Institucional de la UNEDinstname:Universidad Nacional de Educación a DistanciaEspañolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.esoai:e-spacio.uned.es:20.500.14468/318632026-06-15T06:41:27Z
dc.title.none.fl_str_mv Subthalamic stimulation elicits different transient properties of cortical rhythms during open-eyes and closed-eyes resting states
title Subthalamic stimulation elicits different transient properties of cortical rhythms during open-eyes and closed-eyes resting states
spellingShingle Subthalamic stimulation elicits different transient properties of cortical rhythms during open-eyes and closed-eyes resting states
Méndez Bértolo, Constantino José
2490 Neurociencias
Spontaneous EEG activity
Deep brain stimulation
Subthalamic nucleus
Parkinson’s disease
title_short Subthalamic stimulation elicits different transient properties of cortical rhythms during open-eyes and closed-eyes resting states
title_full Subthalamic stimulation elicits different transient properties of cortical rhythms during open-eyes and closed-eyes resting states
title_fullStr Subthalamic stimulation elicits different transient properties of cortical rhythms during open-eyes and closed-eyes resting states
title_full_unstemmed Subthalamic stimulation elicits different transient properties of cortical rhythms during open-eyes and closed-eyes resting states
title_sort Subthalamic stimulation elicits different transient properties of cortical rhythms during open-eyes and closed-eyes resting states
dc.creator.none.fl_str_mv Méndez Bértolo, Constantino José
Sanmartino, Florencia
López-Sosa, Fernando
Cruz-Gómez, Álvaro J.
Lozano-Soto, Elena
Espinosa-Rosso, Raúl
Rashid-López, Raúl
González-Rosa, Javier J.
author Méndez Bértolo, Constantino José
author_facet Méndez Bértolo, Constantino José
Sanmartino, Florencia
López-Sosa, Fernando
Cruz-Gómez, Álvaro J.
Lozano-Soto, Elena
Espinosa-Rosso, Raúl
Rashid-López, Raúl
González-Rosa, Javier J.
author_role author
author2 Sanmartino, Florencia
López-Sosa, Fernando
Cruz-Gómez, Álvaro J.
Lozano-Soto, Elena
Espinosa-Rosso, Raúl
Rashid-López, Raúl
González-Rosa, Javier J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv e-Spacio UNED
dc.subject.none.fl_str_mv 2490 Neurociencias
Spontaneous EEG activity
Deep brain stimulation
Subthalamic nucleus
Parkinson’s disease
topic 2490 Neurociencias
Spontaneous EEG activity
Deep brain stimulation
Subthalamic nucleus
Parkinson’s disease
description Background: Several studies have emphasized on variations in brain functional features between spontaneous brain activity between the eyes-open (EO) and eyes-closed (EC) resting states, assuming that brain activity is a static phenomenon. Besides, Parkinson’s disease (PD) has been associated with characteristic patterns of synchronous oscillatory activity within cortico-basal-ganglia circuits, but the functional relationship between STN-DBS and the brain’s resting state activity is still unclear. The purpose of this study was to investigate the dynamic nature of brain activity in different EO and EC resting conditions and the transient effects on sensorimotor and cortical networks in response to subthalamic stimulation in unmedicated PD patients. Methods: Fifteen unmedicated PD patients treated with bilateral STN-DBS and 17 matched-healthy controls were recruited. Spontaneous electroencephalographic (EEG) activity at rest was recorded during 4 min EC and 4 min EO and during STN-DBS On/Off states in the case of PD patients. Grand average topographical maps were analyzed for extraction of logarithmic spectral power of each EEG frequency band at posterior, central and frontocentral regions. Results: Compared to DBS ‘Off’ state, STN stimulation modulated activity in all frequency bands was unaltered between EC and EO states while dopamine depleted patients power in alpha and theta bands differed. Low and high beta and gamma activity of PD patients in the stimulation OFF condition showed no increases or reductions in comparison with healthy controls while activation in all those frequency bands were modulated by the stimulator state. Conclusions: Our findings may provide insights into the dynamic nature of the resting-state brain activity in PD and suggest that STN-DBS in a dopamine deprived state can selectively regulate the focal character of cortical frequency bands in addition to between EC and EO resting states and particularly for posterior cortical alpha activity, which would rise during PD disease progression.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-02-15
2023
2023-02-15
2026
2026-02-16
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14468/31863
url https://hdl.handle.net/20.500.14468/31863
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:e-spacio (DSpace). Repositorio Institucional de la UNED
instname:Universidad Nacional de Educación a Distancia
instname_str Universidad Nacional de Educación a Distancia
reponame_str e-spacio (DSpace). Repositorio Institucional de la UNED
collection e-spacio (DSpace). Repositorio Institucional de la UNED
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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