Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?

Background: This study was aimed to investigate the acute effect of medium-distance running on bile acids concentration and composition, in order to verify whether the positive impact of physical exercise on cancer risk may also be mediated by variation of bile acids concentration and composition in...

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Autores: Danese, E, Salvagno, GL, Tarperi, C, Negrini, D, Montagnana, M, Festa, L, Sanchis-Gomar, F, Schena, F, Lippi, G
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p4650
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/4650
Access Level:acceso abierto
Palabra clave:bile acids
damage
exercise
sport
gastrointestinal cancer
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spelling Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?Danese, ESalvagno, GLTarperi, CNegrini, DMontagnana, MFesta, LSanchis-Gomar, FSchena, FLippi, Gbile acidsdamageexercisesportgastrointestinal cancerBackground: This study was aimed to investigate the acute effect of medium-distance running on bile acids concentration and composition, in order to verify whether the positive impact of physical exercise on cancer risk may also be mediated by variation of bile acids concentration and composition in serum. Methods: The concentration and composition of serum bile acids was analyzed in 30 middle-aged and healthy recreational athletes with a reference liquid chromatography-mass spectrometry technique, immediately before and shortly after the end of the running trial. The concentration of bile acids after the run was adjusted for plasma volume change. Results: All athletes successfully completed the trial. After correction of values for the individual plasma volume change calculated after the run, the serum concentration of total bile acids was found to be significantly reduced by approximately 46%. A statistically significant decrease was observed for cholic, deoxycholic, chenodeoxycholic, ursodeoxycholic, glycoursodeoxycholic and hyodeoxycholic acids, whereas the concentration of the remaining compounds remained unvaried after the run. A considerable variation of bile acids profile was also observed. No significant association was found between running performance and variation of bile acids concentrations. Conclusion: These results show that middle distance running acutely decreases the concentration of total bile acids in serum, especially that of the more mutagenic and carcinogenic compounds, so providing an intriguing support to the favorable effects of physical exercise for lowering the risk of many gastrointestinal cancers.IMPACT JOURNALS LLC2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/4650OncotargetISSN: 19492553reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p46502026-06-07T16:35:31Z
dc.title.none.fl_str_mv Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?
title Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?
spellingShingle Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?
Danese, E
bile acids
damage
exercise
sport
gastrointestinal cancer
title_short Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?
title_full Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?
title_fullStr Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?
title_full_unstemmed Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?
title_sort Middle-distance running acutely influences the concentration and composition of serum bile acids. Potential implications for cancer risk?
dc.creator.none.fl_str_mv Danese, E
Salvagno, GL
Tarperi, C
Negrini, D
Montagnana, M
Festa, L
Sanchis-Gomar, F
Schena, F
Lippi, G
author Danese, E
author_facet Danese, E
Salvagno, GL
Tarperi, C
Negrini, D
Montagnana, M
Festa, L
Sanchis-Gomar, F
Schena, F
Lippi, G
author_role author
author2 Salvagno, GL
Tarperi, C
Negrini, D
Montagnana, M
Festa, L
Sanchis-Gomar, F
Schena, F
Lippi, G
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv bile acids
damage
exercise
sport
gastrointestinal cancer
topic bile acids
damage
exercise
sport
gastrointestinal cancer
description Background: This study was aimed to investigate the acute effect of medium-distance running on bile acids concentration and composition, in order to verify whether the positive impact of physical exercise on cancer risk may also be mediated by variation of bile acids concentration and composition in serum. Methods: The concentration and composition of serum bile acids was analyzed in 30 middle-aged and healthy recreational athletes with a reference liquid chromatography-mass spectrometry technique, immediately before and shortly after the end of the running trial. The concentration of bile acids after the run was adjusted for plasma volume change. Results: All athletes successfully completed the trial. After correction of values for the individual plasma volume change calculated after the run, the serum concentration of total bile acids was found to be significantly reduced by approximately 46%. A statistically significant decrease was observed for cholic, deoxycholic, chenodeoxycholic, ursodeoxycholic, glycoursodeoxycholic and hyodeoxycholic acids, whereas the concentration of the remaining compounds remained unvaried after the run. A considerable variation of bile acids profile was also observed. No significant association was found between running performance and variation of bile acids concentrations. Conclusion: These results show that middle distance running acutely decreases the concentration of total bile acids in serum, especially that of the more mutagenic and carcinogenic compounds, so providing an intriguing support to the favorable effects of physical exercise for lowering the risk of many gastrointestinal cancers.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/4650
url https://incliva.portalinvestigacion.com/publicaciones/4650
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv IMPACT JOURNALS LLC
publisher.none.fl_str_mv IMPACT JOURNALS LLC
dc.source.none.fl_str_mv Oncotarget
ISSN: 19492553
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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