Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder

Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship with cortical thickness (CTh), clinical features, and neurop...

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Authors: Pardo, Jèssica, Roura, Ignacio, Montal, Victor, Martín Barceló, Cristina, Oltra González, Javier, Campabadal Delgado, Anna, Bargalló Alabart, Núria, Serradell, Mónica, Mayà Casalprim, Gerard, Montini, Angelica, Gaig, Carles, Pont Sunyer, Claustre, Fortea, Juan, Iranzo, Alex, Junqué i Plaja, Carme, 1955-, Segura i Fàbregas, Bàrbara
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Universidad de Oviedo (UNIOVI)
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/225906
Online Access:https://hdl.handle.net/2445/225906
Access Level:Open access
Keyword:Malalties neurodegeneratives
Demència amb cossos de Lewy
Escorça cerebral
Neurodegenerative Diseases
Lewy body dementia
Cerebral cortex
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spelling Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorderPardo, JèssicaRoura, IgnacioMontal, VictorMartín Barceló, CristinaOltra González, JavierCampabadal Delgado, AnnaBargalló Alabart, NúriaSerradell, MónicaMayà Casalprim, GerardMontini, AngelicaGaig, CarlesPont Sunyer, ClaustreFortea, JuanIranzo, AlexJunqué i Plaja, Carme, 1955-Segura i Fàbregas, BàrbaraMalalties neurodegenerativesDemència amb cossos de LewyEscorça cerebralNeurodegenerative DiseasesLewy body dementiaCerebral cortexCortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship with cortical thickness (CTh), clinical features, and neuropsychological performance is also unknown. We assessed cMD and CTh in thirty-six patients with iRBD at high risk of conversion and 29 healthy controls (HC), examining associations with clinical and cognitive measures. Effect sizes were calculated using Cohen's d. Patients with iRBD showed increased cMD in rostral and caudal cortical regions compared to HC (d > 0.5). Cortical thinning was restricted to caudal areas. Higher cMD correlated with longer iRBD duration, later onset, MDS-UPDRS III, apathy, and poorer performance on Grooved Pegboard and Symbol-Digit Modality Tests. These findings suggest that cMD may be more sensitive than CTh and serve as a valuable imaging biomarker for detecting early cortical changes in prodromal LB diseases.   Springer Nature2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/225906Articles publicats en revistes (Fonaments Clínics)reponame:Dipòsit Digital de la UBinstname:Universidad de Oviedo (UNIOVI)InglésReproducció del document publicat a: https://doi.org/10.1038/s41531-025-01058-0npj Parkinson's Disease, 2025, vol. 11, num.1https://doi.org/10.1038/s41531-025-01058-0cc-by-nc-nd (c) Pardo J et al., 2025http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2259062026-05-27T06:46:51Z
dc.title.none.fl_str_mv Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder
title Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder
spellingShingle Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder
Pardo, Jèssica
Malalties neurodegeneratives
Demència amb cossos de Lewy
Escorça cerebral
Neurodegenerative Diseases
Lewy body dementia
Cerebral cortex
title_short Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder
title_full Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder
title_fullStr Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder
title_full_unstemmed Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder
title_sort Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder
dc.creator.none.fl_str_mv Pardo, Jèssica
Roura, Ignacio
Montal, Victor
Martín Barceló, Cristina
Oltra González, Javier
Campabadal Delgado, Anna
Bargalló Alabart, Núria
Serradell, Mónica
Mayà Casalprim, Gerard
Montini, Angelica
Gaig, Carles
Pont Sunyer, Claustre
Fortea, Juan
Iranzo, Alex
Junqué i Plaja, Carme, 1955-
Segura i Fàbregas, Bàrbara
author Pardo, Jèssica
author_facet Pardo, Jèssica
Roura, Ignacio
Montal, Victor
Martín Barceló, Cristina
Oltra González, Javier
Campabadal Delgado, Anna
Bargalló Alabart, Núria
Serradell, Mónica
Mayà Casalprim, Gerard
Montini, Angelica
Gaig, Carles
Pont Sunyer, Claustre
Fortea, Juan
Iranzo, Alex
Junqué i Plaja, Carme, 1955-
Segura i Fàbregas, Bàrbara
author_role author
author2 Roura, Ignacio
Montal, Victor
Martín Barceló, Cristina
Oltra González, Javier
Campabadal Delgado, Anna
Bargalló Alabart, Núria
Serradell, Mónica
Mayà Casalprim, Gerard
Montini, Angelica
Gaig, Carles
Pont Sunyer, Claustre
Fortea, Juan
Iranzo, Alex
Junqué i Plaja, Carme, 1955-
Segura i Fàbregas, Bàrbara
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties neurodegeneratives
Demència amb cossos de Lewy
Escorça cerebral
Neurodegenerative Diseases
Lewy body dementia
Cerebral cortex
topic Malalties neurodegeneratives
Demència amb cossos de Lewy
Escorça cerebral
Neurodegenerative Diseases
Lewy body dementia
Cerebral cortex
description Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship with cortical thickness (CTh), clinical features, and neuropsychological performance is also unknown. We assessed cMD and CTh in thirty-six patients with iRBD at high risk of conversion and 29 healthy controls (HC), examining associations with clinical and cognitive measures. Effect sizes were calculated using Cohen's d. Patients with iRBD showed increased cMD in rostral and caudal cortical regions compared to HC (d > 0.5). Cortical thinning was restricted to caudal areas. Higher cMD correlated with longer iRBD duration, later onset, MDS-UPDRS III, apathy, and poorer performance on Grooved Pegboard and Symbol-Digit Modality Tests. These findings suggest that cMD may be more sensitive than CTh and serve as a valuable imaging biomarker for detecting early cortical changes in prodromal LB diseases.   
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/225906
url https://hdl.handle.net/2445/225906
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41531-025-01058-0
npj Parkinson's Disease, 2025, vol. 11, num.1
https://doi.org/10.1038/s41531-025-01058-0
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Pardo J et al., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Pardo J et al., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Dipòsit Digital de la UB
instname:Universidad de Oviedo (UNIOVI)
instname_str Universidad de Oviedo (UNIOVI)
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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