Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol—A naturally occurring brominated substance

© 2014 by the authors; licensee MDPI, Basel, Switzerland. A new type of antimicrobial, biocompatible and toughness enhanced ultra-thin fiber mats for biomedical applications is presented. The tough and porous fiber mats were obtained by electrospinning solution-blended poly (methyl methacrylate) (PM...

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Autores: Andersson, R.L, Martínez-Abad, Antonio, Lagarón Cabello, José María, Gedde, U.W., Mallon, P.E., Olsson, R.T., Hedenqvist, M.S.
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/109578
Acceso en línea:http://hdl.handle.net/10261/109578
Access Level:acceso abierto
Palabra clave:Poly (methyl methacrylate)
electrospun PMMA/PEO
Fiber mats
Polyethylene oxide
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spelling Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol—A naturally occurring brominated substanceAndersson, R.LMartínez-Abad, AntonioLagarón Cabello, José MaríaGedde, U.W.Mallon, P.E.Olsson, R.T.Hedenqvist, M.S.Poly (methyl methacrylate)electrospun PMMA/PEOFiber matsPolyethylene oxide© 2014 by the authors; licensee MDPI, Basel, Switzerland. A new type of antimicrobial, biocompatible and toughness enhanced ultra-thin fiber mats for biomedical applications is presented. The tough and porous fiber mats were obtained by electrospinning solution-blended poly (methyl methacrylate) (PMMA) and polyethylene oxide (PEO), filled with up to 25 wt % of Lanasol—a naturally occurring brominated cyclic compound that can be extracted from red sea algae. Antibacterial effectiveness was tested following the industrial Standard JIS L 1902 and under agitated medium (ASTM E2149). Even at the lowest concentrations of Lanasol, 4 wt %, a significant bactericidal effect was seen with a 4-log (99.99%) reduction in bacterial viability against S. aureus, which is one of the leading causes of hospital-acquired (nosocomial) infections in the world. The mechanical fiber toughness was insignificantly altered up to the maximum Lanasol concentration tested, and was for all fiber mats orders of magnitudes higher than electrospun fibers based on solely PMMA. This antimicrobial fiber system, relying on a dissolved antimicrobial agent (demonstrated by X-ray diffraction and Infrared (IR)-spectroscopy) rather than a dispersed and “mixed-in” solid antibacterial particle phase, presents a new concept which opens the door to tougher, stronger and more ductile antimicrobial fibers.The Swedish International Development Cooperation Agency (SIDA) is acknowledged for financial support. We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI)Peer ReviewedMultidisciplinary Digital Publishing InstituteConsejo Superior de Investigaciones Científicas (España)2015201520142015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/109578reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglésinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1095782026-05-22T06:33:51Z
dc.title.none.fl_str_mv Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol—A naturally occurring brominated substance
title Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol—A naturally occurring brominated substance
spellingShingle Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol—A naturally occurring brominated substance
Andersson, R.L
Poly (methyl methacrylate)
electrospun PMMA/PEO
Fiber mats
Polyethylene oxide
title_short Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol—A naturally occurring brominated substance
title_full Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol—A naturally occurring brominated substance
title_fullStr Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol—A naturally occurring brominated substance
title_full_unstemmed Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol—A naturally occurring brominated substance
title_sort Antibacterial properties of tough and strong electrospun PMMA/PEO fiber mats filled with lanasol—A naturally occurring brominated substance
dc.creator.none.fl_str_mv Andersson, R.L
Martínez-Abad, Antonio
Lagarón Cabello, José María
Gedde, U.W.
Mallon, P.E.
Olsson, R.T.
Hedenqvist, M.S.
author Andersson, R.L
author_facet Andersson, R.L
Martínez-Abad, Antonio
Lagarón Cabello, José María
Gedde, U.W.
Mallon, P.E.
Olsson, R.T.
Hedenqvist, M.S.
author_role author
author2 Martínez-Abad, Antonio
Lagarón Cabello, José María
Gedde, U.W.
Mallon, P.E.
Olsson, R.T.
Hedenqvist, M.S.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas (España)
dc.subject.none.fl_str_mv Poly (methyl methacrylate)
electrospun PMMA/PEO
Fiber mats
Polyethylene oxide
topic Poly (methyl methacrylate)
electrospun PMMA/PEO
Fiber mats
Polyethylene oxide
description © 2014 by the authors; licensee MDPI, Basel, Switzerland. A new type of antimicrobial, biocompatible and toughness enhanced ultra-thin fiber mats for biomedical applications is presented. The tough and porous fiber mats were obtained by electrospinning solution-blended poly (methyl methacrylate) (PMMA) and polyethylene oxide (PEO), filled with up to 25 wt % of Lanasol—a naturally occurring brominated cyclic compound that can be extracted from red sea algae. Antibacterial effectiveness was tested following the industrial Standard JIS L 1902 and under agitated medium (ASTM E2149). Even at the lowest concentrations of Lanasol, 4 wt %, a significant bactericidal effect was seen with a 4-log (99.99%) reduction in bacterial viability against S. aureus, which is one of the leading causes of hospital-acquired (nosocomial) infections in the world. The mechanical fiber toughness was insignificantly altered up to the maximum Lanasol concentration tested, and was for all fiber mats orders of magnitudes higher than electrospun fibers based on solely PMMA. This antimicrobial fiber system, relying on a dissolved antimicrobial agent (demonstrated by X-ray diffraction and Infrared (IR)-spectroscopy) rather than a dispersed and “mixed-in” solid antibacterial particle phase, presents a new concept which opens the door to tougher, stronger and more ductile antimicrobial fibers.
publishDate 2014
dc.date.none.fl_str_mv 2014
2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/109578
url http://hdl.handle.net/10261/109578
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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