Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004)

We provide population-based long-term survival indicators of breast cancer patients by quantifying the observed survival, and the probabilities of death due to breast cancer and to other causes by age and tumor stage at diagnosis. Methods: We included a total of 10,195 female patients diagnosed befo...

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Autores: Clèries, Ramon, Ameijide, Alberto, Buxó Pujolràs, Maria, Martínez, José Miguel, Marcos-Gragera, Rafael, Vilardell, Maria Loreto, Carulla, Marià, Yasui, Yutaka, Vilardell, Mireia, Espinàs, Josep Alfons, Borràs Andrés, Josep Maria, Galceran, Jaume, Izquierdo i Font, Àngel Xavier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/16975
Acceso en línea:http://hdl.handle.net/10256/16975
Access Level:acceso abierto
Palabra clave:Mama -- Càncer
Breast -- Cancer
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spelling Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004)Clèries, RamonAmeijide, AlbertoBuxó Pujolràs, MariaMartínez, José MiguelMarcos-Gragera, RafaelVilardell, Maria LoretoCarulla, MariàYasui, YutakaVilardell, MireiaEspinàs, Josep AlfonsBorràs Andrés, Josep MariaGalceran, JaumeIzquierdo i Font, Àngel XavierMama -- CàncerBreast -- CancerWe provide population-based long-term survival indicators of breast cancer patients by quantifying the observed survival, and the probabilities of death due to breast cancer and to other causes by age and tumor stage at diagnosis. Methods: We included a total of 10,195 female patients diagnosed before 85 years with invasive primary breast cancer in Girona and Tarragona during the periods 1985–1994 and 1995–2004 and followed-up until December 31st 2014. The survival indicators were estimated at 5, 10, 15 and 20 years of follow-up comparing diagnostic periods. Results: Comparing diagnostic periods: I) the probability of death due to other causes did not change; II) the 20-year survival for women diagnosed ≤ 49 years increased 13% (1995–2004 = 68%; 1985–1994:55%), whereas their probability of death due to breast cancer decreased at the same pace (1995–2004 = 29%; 1985–1994 = 42%); III) at 10 years of follow-up, decreases in the probabilities of death due to breast cancer across age groups switched from 11 to 17% resulting in a risk of death reduction of 19% after adjusting by stage. During 1995–2004, the stage-specific 10-year probabilities of death due to breast cancer switched from: 3–6% in stage I, 18–20% in stage II, 34–46% in stage III and surpassed 70% in stage IV beyond 5 years after diagnosis. Conclusions: In our study, women diagnosed with breast cancer had higher long-term probability to die from breast cancer than from other causes. The improvements in treatment and the lead-time bias in detecting cancer in an early stage resulted in a reduction of 19% in the risk of death between diagnostic periodsThis work was supported by Instituto de Salud Carlos III through the Project PI14/01041, co-funded by FEDER funds/ European Regional Development Fund (ERDF)-a way to Build Europe-// FONDOS FEDER “una manera de hacer Europa”. The Agència d’Avaluació d’Universitats i Recerca (2014SGR0635) partially supported this studySpringer2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/16975Clinical and Translational Oncology, 2018, vol. 20, núm. 10, p. 1252-1260Articles publicats (D-I)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s12094-018-1852-1info:eu-repo/semantics/altIdentifier/issn/1699-048Xinfo:eu-repo/semantics/altIdentifier/eissn/1699-3055Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/169752026-05-29T05:05:01Z
dc.title.none.fl_str_mv Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004)
title Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004)
spellingShingle Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004)
Clèries, Ramon
Mama -- Càncer
Breast -- Cancer
title_short Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004)
title_full Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004)
title_fullStr Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004)
title_full_unstemmed Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004)
title_sort Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004)
dc.creator.none.fl_str_mv Clèries, Ramon
Ameijide, Alberto
Buxó Pujolràs, Maria
Martínez, José Miguel
Marcos-Gragera, Rafael
Vilardell, Maria Loreto
Carulla, Marià
Yasui, Yutaka
Vilardell, Mireia
Espinàs, Josep Alfons
Borràs Andrés, Josep Maria
Galceran, Jaume
Izquierdo i Font, Àngel Xavier
author Clèries, Ramon
author_facet Clèries, Ramon
Ameijide, Alberto
Buxó Pujolràs, Maria
Martínez, José Miguel
Marcos-Gragera, Rafael
Vilardell, Maria Loreto
Carulla, Marià
Yasui, Yutaka
Vilardell, Mireia
Espinàs, Josep Alfons
Borràs Andrés, Josep Maria
Galceran, Jaume
Izquierdo i Font, Àngel Xavier
author_role author
author2 Ameijide, Alberto
Buxó Pujolràs, Maria
Martínez, José Miguel
Marcos-Gragera, Rafael
Vilardell, Maria Loreto
Carulla, Marià
Yasui, Yutaka
Vilardell, Mireia
Espinàs, Josep Alfons
Borràs Andrés, Josep Maria
Galceran, Jaume
Izquierdo i Font, Àngel Xavier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mama -- Càncer
Breast -- Cancer
topic Mama -- Càncer
Breast -- Cancer
description We provide population-based long-term survival indicators of breast cancer patients by quantifying the observed survival, and the probabilities of death due to breast cancer and to other causes by age and tumor stage at diagnosis. Methods: We included a total of 10,195 female patients diagnosed before 85 years with invasive primary breast cancer in Girona and Tarragona during the periods 1985–1994 and 1995–2004 and followed-up until December 31st 2014. The survival indicators were estimated at 5, 10, 15 and 20 years of follow-up comparing diagnostic periods. Results: Comparing diagnostic periods: I) the probability of death due to other causes did not change; II) the 20-year survival for women diagnosed ≤ 49 years increased 13% (1995–2004 = 68%; 1985–1994:55%), whereas their probability of death due to breast cancer decreased at the same pace (1995–2004 = 29%; 1985–1994 = 42%); III) at 10 years of follow-up, decreases in the probabilities of death due to breast cancer across age groups switched from 11 to 17% resulting in a risk of death reduction of 19% after adjusting by stage. During 1995–2004, the stage-specific 10-year probabilities of death due to breast cancer switched from: 3–6% in stage I, 18–20% in stage II, 34–46% in stage III and surpassed 70% in stage IV beyond 5 years after diagnosis. Conclusions: In our study, women diagnosed with breast cancer had higher long-term probability to die from breast cancer than from other causes. The improvements in treatment and the lead-time bias in detecting cancer in an early stage resulted in a reduction of 19% in the risk of death between diagnostic periods
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/16975
url http://hdl.handle.net/10256/16975
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s12094-018-1852-1
info:eu-repo/semantics/altIdentifier/issn/1699-048X
info:eu-repo/semantics/altIdentifier/eissn/1699-3055
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Clinical and Translational Oncology, 2018, vol. 20, núm. 10, p. 1252-1260
Articles publicats (D-I)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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