Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance

Multi-resistant pathogens can cause several nosocomial infections that can harm hospital interventions or undermine biological processes. In this scenario, the development of novel and efficient antimicrobial materials is essential for reducing pathogen spread. Though many approaches have been follo...

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Autores: Bolaños-Cardet, Jose, Ruiz Molina, Daniel, Yuste, Víctor J., Suárez-García, Salvio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/356572
Acceso en línea:http://hdl.handle.net/10261/356572
Access Level:acceso abierto
Palabra clave:Bioinspired
Catechol
Coatings
Multi-resistant bacteria
Antimicrobial
Healthcare
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spelling Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistanceBolaños-Cardet, JoseRuiz Molina, DanielYuste, Víctor J.Suárez-García, SalvioBioinspiredCatecholCoatingsMulti-resistant bacteriaAntimicrobialHealthcareMulti-resistant pathogens can cause several nosocomial infections that can harm hospital interventions or undermine biological processes. In this scenario, the development of novel and efficient antimicrobial materials is essential for reducing pathogen spread. Though many approaches have been followed with this aim, scalability, safety, and efficiency concerns still hamper their clinical transfer. In this work, we overcome these limitations by co-polymerizing phenolic derivatives with amino-terminal ligands. The resulting coatings are successfully applied to woven and non-woven-based materials used in healthcare: paper, cotton and polypropylene. Moreover, the coatings demonstrate multi-pathway antimicrobial activity against six bacteria (E. coli, P. aeruginosa, S. aureus, methicillin-resistant S. aureus, E. faecalis, and B. subtilis) and two fungi (C. albicans and C. auris), a fact attributed to i) reactive oxygen species generation over time and ii) protic amino groups exposed on the surface. After 180 min, viable bacteria are reduced by more than 99.9 %, with a comparable decline in fungi after 24 h. As a proof-of-concept, coated commercial band-aids tested on skin ex vivo reduced bacterial growth by about 90 %. Considering these results and long-lasting, in vitro biocompatibility, scalability and eco-friendly technology, these coatings represent a promising alternative to be applied in healthcare environments, avoiding pathogen spread, infections and antimicrobial resistance.This work was supported by grant PID2021-127983OB-C21 financed by MCIN/ AEI/10.13039/501100011033/ and ERDF “A way to make Europe”, and SAF2017-83206-R funded by MCIN/Government of Spain and ERDF “A way to make Europe”. The ICN2 is funded by the CERCA programme/Generalitat de Catalunya. The ICN2 is supported by the Severo Ochoa Centres of Excellence programme, Grant CEX2021-001214-S, funded by MCIN/AEI/10.13039.501100011033. JB-C is recipient of a “Personal Investigador en Formació” fellow (2020/D/LE/CC/3) from Universitat Autònoma de Barcelona.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001214-S).Peer reviewedElsevierMinisterio de Ciencia, Innovación y Universidades (España)European CommissionMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Generalitat de CatalunyaUniversidad Autónoma de BarcelonaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/356572reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127983OB-C21info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-83206-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001214-SThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.cej.2024.148674https://doi.org/10.1016/j.cej.2024.148674Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3565722026-05-22T06:33:51Z
dc.title.none.fl_str_mv Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance
title Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance
spellingShingle Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance
Bolaños-Cardet, Jose
Bioinspired
Catechol
Coatings
Multi-resistant bacteria
Antimicrobial
Healthcare
title_short Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance
title_full Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance
title_fullStr Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance
title_full_unstemmed Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance
title_sort Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance
dc.creator.none.fl_str_mv Bolaños-Cardet, Jose
Ruiz Molina, Daniel
Yuste, Víctor J.
Suárez-García, Salvio
author Bolaños-Cardet, Jose
author_facet Bolaños-Cardet, Jose
Ruiz Molina, Daniel
Yuste, Víctor J.
Suárez-García, Salvio
author_role author
author2 Ruiz Molina, Daniel
Yuste, Víctor J.
Suárez-García, Salvio
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Generalitat de Catalunya
Universidad Autónoma de Barcelona
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bioinspired
Catechol
Coatings
Multi-resistant bacteria
Antimicrobial
Healthcare
topic Bioinspired
Catechol
Coatings
Multi-resistant bacteria
Antimicrobial
Healthcare
description Multi-resistant pathogens can cause several nosocomial infections that can harm hospital interventions or undermine biological processes. In this scenario, the development of novel and efficient antimicrobial materials is essential for reducing pathogen spread. Though many approaches have been followed with this aim, scalability, safety, and efficiency concerns still hamper their clinical transfer. In this work, we overcome these limitations by co-polymerizing phenolic derivatives with amino-terminal ligands. The resulting coatings are successfully applied to woven and non-woven-based materials used in healthcare: paper, cotton and polypropylene. Moreover, the coatings demonstrate multi-pathway antimicrobial activity against six bacteria (E. coli, P. aeruginosa, S. aureus, methicillin-resistant S. aureus, E. faecalis, and B. subtilis) and two fungi (C. albicans and C. auris), a fact attributed to i) reactive oxygen species generation over time and ii) protic amino groups exposed on the surface. After 180 min, viable bacteria are reduced by more than 99.9 %, with a comparable decline in fungi after 24 h. As a proof-of-concept, coated commercial band-aids tested on skin ex vivo reduced bacterial growth by about 90 %. Considering these results and long-lasting, in vitro biocompatibility, scalability and eco-friendly technology, these coatings represent a promising alternative to be applied in healthcare environments, avoiding pathogen spread, infections and antimicrobial resistance.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/356572
url http://hdl.handle.net/10261/356572
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127983OB-C21
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-83206-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001214-S
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.cej.2024.148674
https://doi.org/10.1016/j.cej.2024.148674
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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