Interrelation of adipose tissue macrophages and fibrosis in obesity

Obesity is characterized by adipose tissue expansion, extracellular matrix remodelling and unresolved inflammation that contribute to insulin resistance and fibrosis. Adipose tissue macrophages represent the most abundant class of immune cells in adipose tissue inflammation and could be key mediator...

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Detalles Bibliográficos
Autores: Dahdah, Norma, Tercero Alcázar, Carmen, Malagón Poyato, María del Mar, García Roves, Pablo Miguel, Guzmán Ruiz, Rocío
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/214192
Acceso en línea:https://hdl.handle.net/2445/214192
Access Level:acceso abierto
Palabra clave:Obesitat
Comorbiditat
Obesity
Comorbidity
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spelling Interrelation of adipose tissue macrophages and fibrosis in obesityDahdah, NormaTercero Alcázar, CarmenMalagón Poyato, María del MarGarcía Roves, Pablo MiguelGuzmán Ruiz, RocíoObesitatComorbiditatObesityComorbidityObesity is characterized by adipose tissue expansion, extracellular matrix remodelling and unresolved inflammation that contribute to insulin resistance and fibrosis. Adipose tissue macrophages represent the most abundant class of immune cells in adipose tissue inflammation and could be key mediators of adipocyte dysfunction and fibrosis in obesity. Although macrophage activation states are classically defined by the M1/M2 polarization nomenclature, novel studies have revealed a more complex range of macrophage phenotypes in response to external condition or the surrounding microenvironment. Here, we discuss the plasticity of adipose tissue macrophages (ATMs) in response to their microenvironment in obesity, with special focus on macrophage infiltration and polarization, and their contribution to adipose tissue fibrosis. A better understanding of the role of ATMs as regulators of adipose tissue remodelling may provide novel therapeutic strategies against obesity and associated metabolic diseases.Elsevier BV2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/214192Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.bcp.2024.116324Biochemical Pharmacology, 2024, vol. 225, p. 116324https://doi.org/10.1016/j.bcp.2024.116324cc by (c) Dahdah, Norma et al, 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2141922026-05-27T06:46:51Z
dc.title.none.fl_str_mv Interrelation of adipose tissue macrophages and fibrosis in obesity
title Interrelation of adipose tissue macrophages and fibrosis in obesity
spellingShingle Interrelation of adipose tissue macrophages and fibrosis in obesity
Dahdah, Norma
Obesitat
Comorbiditat
Obesity
Comorbidity
title_short Interrelation of adipose tissue macrophages and fibrosis in obesity
title_full Interrelation of adipose tissue macrophages and fibrosis in obesity
title_fullStr Interrelation of adipose tissue macrophages and fibrosis in obesity
title_full_unstemmed Interrelation of adipose tissue macrophages and fibrosis in obesity
title_sort Interrelation of adipose tissue macrophages and fibrosis in obesity
dc.creator.none.fl_str_mv Dahdah, Norma
Tercero Alcázar, Carmen
Malagón Poyato, María del Mar
García Roves, Pablo Miguel
Guzmán Ruiz, Rocío
author Dahdah, Norma
author_facet Dahdah, Norma
Tercero Alcázar, Carmen
Malagón Poyato, María del Mar
García Roves, Pablo Miguel
Guzmán Ruiz, Rocío
author_role author
author2 Tercero Alcázar, Carmen
Malagón Poyato, María del Mar
García Roves, Pablo Miguel
Guzmán Ruiz, Rocío
author2_role author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Comorbiditat
Obesity
Comorbidity
topic Obesitat
Comorbiditat
Obesity
Comorbidity
description Obesity is characterized by adipose tissue expansion, extracellular matrix remodelling and unresolved inflammation that contribute to insulin resistance and fibrosis. Adipose tissue macrophages represent the most abundant class of immune cells in adipose tissue inflammation and could be key mediators of adipocyte dysfunction and fibrosis in obesity. Although macrophage activation states are classically defined by the M1/M2 polarization nomenclature, novel studies have revealed a more complex range of macrophage phenotypes in response to external condition or the surrounding microenvironment. Here, we discuss the plasticity of adipose tissue macrophages (ATMs) in response to their microenvironment in obesity, with special focus on macrophage infiltration and polarization, and their contribution to adipose tissue fibrosis. A better understanding of the role of ATMs as regulators of adipose tissue remodelling may provide novel therapeutic strategies against obesity and associated metabolic diseases.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214192
url https://hdl.handle.net/2445/214192
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.bcp.2024.116324
Biochemical Pharmacology, 2024, vol. 225, p. 116324
https://doi.org/10.1016/j.bcp.2024.116324
dc.rights.none.fl_str_mv cc by (c) Dahdah, Norma et al, 2024
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Dahdah, Norma et al, 2024
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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