The reversibility of cellular mechano-activation

The cellular microenvironment is highly heterogeneous and dynamic. Therefore, cells must be equipped with molecular tools to adapt and respond to constantly fluctuating inputs. One such input is mechanical force, which activates signalling and regulates cell behaviour in the process of mechanotransd...

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Detalles Bibliográficos
Autores: Beedle, Amy E. M., Roca-Cusachs Soulere, Pere
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/201872
Acceso en línea:https://hdl.handle.net/2445/201872
Access Level:acceso abierto
Palabra clave:Transducció de senyal cel·lular
Fisiologia cel·lular
Cellular signal transduction
Cell physiology
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spelling The reversibility of cellular mechano-activationBeedle, Amy E. M.Roca-Cusachs Soulere, PereTransducció de senyal cel·lularFisiologia cel·lularCellular signal transductionCell physiologyThe cellular microenvironment is highly heterogeneous and dynamic. Therefore, cells must be equipped with molecular tools to adapt and respond to constantly fluctuating inputs. One such input is mechanical force, which activates signalling and regulates cell behaviour in the process of mechanotransduction. Whereas the mechanisms activating mechanotransduction are well studied, the reversibility of this process, whereby cells disassemble and reverse force-activated signalling pathways upon cessation of mechanical stimulation is far less understood. In this review we will outline some of the key experimental techniques to investigate the reversibility of mechanical signalling, and key discoveries arising from them.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.Elsevier BV2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/201872Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaIngléshttps://doi.org/10.1016/j.ceb.2023.102229Current Opinion In Cell Biology, 2023, vol. 84https://doi.org/10.1016/j.ceb.2023.102229cc by-nc (c) Beedle, Amy EM. et al., 2023http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2018722026-05-27T06:46:51Z
dc.title.none.fl_str_mv The reversibility of cellular mechano-activation
title The reversibility of cellular mechano-activation
spellingShingle The reversibility of cellular mechano-activation
Beedle, Amy E. M.
Transducció de senyal cel·lular
Fisiologia cel·lular
Cellular signal transduction
Cell physiology
title_short The reversibility of cellular mechano-activation
title_full The reversibility of cellular mechano-activation
title_fullStr The reversibility of cellular mechano-activation
title_full_unstemmed The reversibility of cellular mechano-activation
title_sort The reversibility of cellular mechano-activation
dc.creator.none.fl_str_mv Beedle, Amy E. M.
Roca-Cusachs Soulere, Pere
author Beedle, Amy E. M.
author_facet Beedle, Amy E. M.
Roca-Cusachs Soulere, Pere
author_role author
author2 Roca-Cusachs Soulere, Pere
author2_role author
dc.subject.none.fl_str_mv Transducció de senyal cel·lular
Fisiologia cel·lular
Cellular signal transduction
Cell physiology
topic Transducció de senyal cel·lular
Fisiologia cel·lular
Cellular signal transduction
Cell physiology
description The cellular microenvironment is highly heterogeneous and dynamic. Therefore, cells must be equipped with molecular tools to adapt and respond to constantly fluctuating inputs. One such input is mechanical force, which activates signalling and regulates cell behaviour in the process of mechanotransduction. Whereas the mechanisms activating mechanotransduction are well studied, the reversibility of this process, whereby cells disassemble and reverse force-activated signalling pathways upon cessation of mechanical stimulation is far less understood. In this review we will outline some of the key experimental techniques to investigate the reversibility of mechanical signalling, and key discoveries arising from them.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/201872
url https://hdl.handle.net/2445/201872
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.ceb.2023.102229
Current Opinion In Cell Biology, 2023, vol. 84
https://doi.org/10.1016/j.ceb.2023.102229
dc.rights.none.fl_str_mv cc by-nc (c) Beedle, Amy EM. et al., 2023
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Beedle, Amy EM. et al., 2023
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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