Human-specific changes in two functional enhancers of FOXP2

FOXP2 is a gene involved in language development and function. Neanderthals and humans share the same coding region of the gene, although the formers are thought to have exhibited less sophisticated language abilities. In this paper, we report on several human-specific changes in two functional enha...

Descripción completa

Detalles Bibliográficos
Autores: Benítez Burraco, Antonio, Torres-Ruiz, Raúl, Gelabert, Pere, Lalueza-Fox, Carles, Rodríguez-Perales, Sandra, García-Bellido, Paloma
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/170776
Acceso en línea:https://hdl.handle.net/11441/170776
https://doi.org/10.14715/cmb/2022.68.11.3
Access Level:acceso abierto
Palabra clave:human evolution
language evolution
FOXP2
enhancers
Neanderthals
SMARCC1
id ES_fde641e6578f66a0ecf0b7ef6e42ac8a
oai_identifier_str oai:idus.us.es:11441/170776
network_acronym_str ES
network_name_str España
repository_id_str
spelling Human-specific changes in two functional enhancers of FOXP2Benítez Burraco, AntonioTorres-Ruiz, RaúlGelabert, PereLalueza-Fox, CarlesRodríguez-Perales, SandraGarcía-Bellido, Palomahuman evolutionlanguage evolutionFOXP2enhancersNeanderthalsSMARCC1FOXP2 is a gene involved in language development and function. Neanderthals and humans share the same coding region of the gene, although the formers are thought to have exhibited less sophisticated language abilities. In this paper, we report on several human-specific changes in two functional enhancers of FOXP2. Two of these variants are located within the binding sites for the transcription factors POLR2A and SMARCC1, respectively. Interestingly, SMARCC1 is involved in brain development and vitamin D metabolism. We hypothesize that the human specific change in this position might have resulted in a different regulation pattern of FOXP2 expression in our species compared to extinct hominins, with a potential impact on our language abilities.Cellular and Molecular BiologyLengua Española, Lingüística y Teoría de la LiteraturaHUM972: Biolingüística2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/170776https://doi.org/10.14715/cmb/2022.68.11.3reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésCellular and Molecular Biology, 68 (11), 16-19.https://cellmolbiol.org/index.php/CMB/article/view/4586info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1707762026-06-17T12:51:07Z
dc.title.none.fl_str_mv Human-specific changes in two functional enhancers of FOXP2
title Human-specific changes in two functional enhancers of FOXP2
spellingShingle Human-specific changes in two functional enhancers of FOXP2
Benítez Burraco, Antonio
human evolution
language evolution
FOXP2
enhancers
Neanderthals
SMARCC1
title_short Human-specific changes in two functional enhancers of FOXP2
title_full Human-specific changes in two functional enhancers of FOXP2
title_fullStr Human-specific changes in two functional enhancers of FOXP2
title_full_unstemmed Human-specific changes in two functional enhancers of FOXP2
title_sort Human-specific changes in two functional enhancers of FOXP2
dc.creator.none.fl_str_mv Benítez Burraco, Antonio
Torres-Ruiz, Raúl
Gelabert, Pere
Lalueza-Fox, Carles
Rodríguez-Perales, Sandra
García-Bellido, Paloma
author Benítez Burraco, Antonio
author_facet Benítez Burraco, Antonio
Torres-Ruiz, Raúl
Gelabert, Pere
Lalueza-Fox, Carles
Rodríguez-Perales, Sandra
García-Bellido, Paloma
author_role author
author2 Torres-Ruiz, Raúl
Gelabert, Pere
Lalueza-Fox, Carles
Rodríguez-Perales, Sandra
García-Bellido, Paloma
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Lengua Española, Lingüística y Teoría de la Literatura
HUM972: Biolingüística
dc.subject.none.fl_str_mv human evolution
language evolution
FOXP2
enhancers
Neanderthals
SMARCC1
topic human evolution
language evolution
FOXP2
enhancers
Neanderthals
SMARCC1
description FOXP2 is a gene involved in language development and function. Neanderthals and humans share the same coding region of the gene, although the formers are thought to have exhibited less sophisticated language abilities. In this paper, we report on several human-specific changes in two functional enhancers of FOXP2. Two of these variants are located within the binding sites for the transcription factors POLR2A and SMARCC1, respectively. Interestingly, SMARCC1 is involved in brain development and vitamin D metabolism. We hypothesize that the human specific change in this position might have resulted in a different regulation pattern of FOXP2 expression in our species compared to extinct hominins, with a potential impact on our language abilities.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/170776
https://doi.org/10.14715/cmb/2022.68.11.3
url https://hdl.handle.net/11441/170776
https://doi.org/10.14715/cmb/2022.68.11.3
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cellular and Molecular Biology, 68 (11), 16-19.
https://cellmolbiol.org/index.php/CMB/article/view/4586
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cellular and Molecular Biology
publisher.none.fl_str_mv Cellular and Molecular Biology
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425608406073344
score 15,811543

Similares en LA Referencia