A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children

Acute respiratory infections remain the principal cause of morbidity and mortality in Moroccan children. Besides bacterial infections, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are prominent among other viruses due to their high prevalence and association with severe clinica...

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Autores: Jroundi I, Mahraoui C, Benmessaoud R, Moraleda C, Tligui H, Seffar M, El Kettani SE, Benjelloun BS, Chaacho S, Muñoz-Almagro C, Ruiz J, Alonso PL, Bassat Q
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p11513
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11513
Access Level:acceso abierto
Palabra clave:Human metapneumovirus
respiratory syncytial virus
pneumonia
Morocco
children
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spelling A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan childrenJroundi IMahraoui CBenmessaoud RMoraleda CTligui HSeffar MEl Kettani SEBenjelloun BSChaacho SMuñoz-Almagro CRuiz JAlonso PLBassat QHuman metapneumovirusrespiratory syncytial viruspneumoniaMoroccochildrenAcute respiratory infections remain the principal cause of morbidity and mortality in Moroccan children. Besides bacterial infections, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are prominent among other viruses due to their high prevalence and association with severe clinical episodes. We aimed to describe and compare RSV- and hMPV-associated cases of WHO-defined severe pneumonia in a paediatric population admitted to Morocco's reference hospital. Children aged 2-59 months admitted to the Hopital d'Enfants de Rabat, Morocco meeting WHO-defined severe pneumonia criteria were recruited during 14 months and thoroughly investigated to ascertain a definitive diagnosis. Viral prevalence of RSV, hMPV and other viruses causing respiratory symptoms was investigated in nasopharyngeal aspirate samples through the use of molecular methods. Of the 683 children recruited and included in the final analysis, 61/683 (8.9%) and 124/683 (18.2%) were infected with hMPV and RSV, respectively. Besides a borderline significant tendency for higher age in hMPV cases, patients infected with either of the viruses behaved similarly in terms of demographics, patient history, past morbidity and comorbidity, vaccination history, socioeconomic background and family environment. Clinical presentation on arrival was also similar for both viruses, but hMPV cases were associated with more severity than RSV cases, had a higher risk of intensive care need, and received antibiotic treatment more frequently. RSV and hMPV are common and potentially life-threatening causes of WHO-defined pneumonia in Moroccan children. Both viruses show indistinctive clinical symptomatology, but in Moroccan children, hMPV was associated with a more severe evolution.CAMBRIDGE UNIV PRESS2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11513Epidemiology & InfectionISSN: 09502688ISSNe: 14694409reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p115132026-05-27T12:37:41Z
dc.title.none.fl_str_mv A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children
title A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children
spellingShingle A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children
Jroundi I
Human metapneumovirus
respiratory syncytial virus
pneumonia
Morocco
children
title_short A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children
title_full A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children
title_fullStr A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children
title_full_unstemmed A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children
title_sort A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children
dc.creator.none.fl_str_mv Jroundi I
Mahraoui C
Benmessaoud R
Moraleda C
Tligui H
Seffar M
El Kettani SE
Benjelloun BS
Chaacho S
Muñoz-Almagro C
Ruiz J
Alonso PL
Bassat Q
author Jroundi I
author_facet Jroundi I
Mahraoui C
Benmessaoud R
Moraleda C
Tligui H
Seffar M
El Kettani SE
Benjelloun BS
Chaacho S
Muñoz-Almagro C
Ruiz J
Alonso PL
Bassat Q
author_role author
author2 Mahraoui C
Benmessaoud R
Moraleda C
Tligui H
Seffar M
El Kettani SE
Benjelloun BS
Chaacho S
Muñoz-Almagro C
Ruiz J
Alonso PL
Bassat Q
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Human metapneumovirus
respiratory syncytial virus
pneumonia
Morocco
children
topic Human metapneumovirus
respiratory syncytial virus
pneumonia
Morocco
children
description Acute respiratory infections remain the principal cause of morbidity and mortality in Moroccan children. Besides bacterial infections, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are prominent among other viruses due to their high prevalence and association with severe clinical episodes. We aimed to describe and compare RSV- and hMPV-associated cases of WHO-defined severe pneumonia in a paediatric population admitted to Morocco's reference hospital. Children aged 2-59 months admitted to the Hopital d'Enfants de Rabat, Morocco meeting WHO-defined severe pneumonia criteria were recruited during 14 months and thoroughly investigated to ascertain a definitive diagnosis. Viral prevalence of RSV, hMPV and other viruses causing respiratory symptoms was investigated in nasopharyngeal aspirate samples through the use of molecular methods. Of the 683 children recruited and included in the final analysis, 61/683 (8.9%) and 124/683 (18.2%) were infected with hMPV and RSV, respectively. Besides a borderline significant tendency for higher age in hMPV cases, patients infected with either of the viruses behaved similarly in terms of demographics, patient history, past morbidity and comorbidity, vaccination history, socioeconomic background and family environment. Clinical presentation on arrival was also similar for both viruses, but hMPV cases were associated with more severity than RSV cases, had a higher risk of intensive care need, and received antibiotic treatment more frequently. RSV and hMPV are common and potentially life-threatening causes of WHO-defined pneumonia in Moroccan children. Both viruses show indistinctive clinical symptomatology, but in Moroccan children, hMPV was associated with a more severe evolution.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11513
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11513
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
dc.source.none.fl_str_mv Epidemiology & Infection
ISSN: 09502688
ISSNe: 14694409
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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