Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder

Background: Manic-depression or bipolar disorder (BD) is a multi-faceted illness with an inevitably complex treatment. Methods: This article summarizes the current status of our knowledge and practice of its treatment. Results: It is widely accepted that lithium is moderately useful during all phase...

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Autores: Fountoulakis, Konstantinos N., Vieta i Pascual, Eduard, 1963-, Siamouli, Melenia, Valentí Ribas, Marc, Magiria, Stamatia, Oral, Timuciu, Fresno, David, Giannakopoulos, Panteleimon, Kaprinis, George S.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2007
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/7306
Acesso em linha:https://hdl.handle.net/2445/7306
Access Level:acceso abierto
Palavra-chave:Psicosi maníacodepressiva
Teràpia cognitiva
Bipolar disorders
Cognitive therapy
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spelling Treatment of bipolar disorder: a complex treatment for a multi-faceted disorderFountoulakis, Konstantinos N.Vieta i Pascual, Eduard, 1963-Siamouli, MeleniaValentí Ribas, MarcMagiria, StamatiaOral, TimuciuFresno, DavidGiannakopoulos, PanteleimonKaprinis, George S.Psicosi maníacodepressivaTeràpia cognitivaBipolar disordersCognitive therapyBackground: Manic-depression or bipolar disorder (BD) is a multi-faceted illness with an inevitably complex treatment. Methods: This article summarizes the current status of our knowledge and practice of its treatment. Results: It is widely accepted that lithium is moderately useful during all phases of bipolar illness and it might possess a specific effectiveness on suicidal prevention. Both first and second generation antipsychotics are widely used and the FDA has approved olanzapine, risperidone, quetiapine, ziprasidone and aripiprazole for the treatment of acute mania. These could also be useful in the treatment of bipolar depression, but only limited data exists so far to support the use of quetiapine monotherapy or the olanzapine-fluoxetine combination. Some, but not all, anticonvulsants possess a broad spectrum of effectiveness, including mixed dysphoric and rapid-cycling forms. Lamotrigine may be effective in the treatment of depression but not mania. Antidepressant use is controversial. Guidelines suggest their cautious use in combination with an antimanic agent, because they are supposed to induce switching to mania or hypomania, mixed episodes and rapid cycling. Conclusion: The first-line psychosocial intervention in BD is psychoeducation, followed by cognitive-behavioral therapy. Other treatment options include Electroconvulsive therapy and transcranial magnetic stimulation. There is a gap between the evidence base, which comes mostly from monotherapy trials, and clinical practice, where complex treatment regimens are the rule.BioMed Central200920092007info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/7306Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a http://dx.doi.org/10.1186/1744-859X-6-27Annals of General Psychiatry, 2007, vol. 6, núm. 27http://dx.doi.org/10.1186/1744-859X-6-27cc-by, (c) Fountoulakis et al., 2007http://creativecommons.org/licenses/by/2.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/73062026-05-29T05:05:01Z
dc.title.none.fl_str_mv Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder
title Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder
spellingShingle Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder
Fountoulakis, Konstantinos N.
Psicosi maníacodepressiva
Teràpia cognitiva
Bipolar disorders
Cognitive therapy
title_short Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder
title_full Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder
title_fullStr Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder
title_full_unstemmed Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder
title_sort Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder
dc.creator.none.fl_str_mv Fountoulakis, Konstantinos N.
Vieta i Pascual, Eduard, 1963-
Siamouli, Melenia
Valentí Ribas, Marc
Magiria, Stamatia
Oral, Timuciu
Fresno, David
Giannakopoulos, Panteleimon
Kaprinis, George S.
author Fountoulakis, Konstantinos N.
author_facet Fountoulakis, Konstantinos N.
Vieta i Pascual, Eduard, 1963-
Siamouli, Melenia
Valentí Ribas, Marc
Magiria, Stamatia
Oral, Timuciu
Fresno, David
Giannakopoulos, Panteleimon
Kaprinis, George S.
author_role author
author2 Vieta i Pascual, Eduard, 1963-
Siamouli, Melenia
Valentí Ribas, Marc
Magiria, Stamatia
Oral, Timuciu
Fresno, David
Giannakopoulos, Panteleimon
Kaprinis, George S.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psicosi maníacodepressiva
Teràpia cognitiva
Bipolar disorders
Cognitive therapy
topic Psicosi maníacodepressiva
Teràpia cognitiva
Bipolar disorders
Cognitive therapy
description Background: Manic-depression or bipolar disorder (BD) is a multi-faceted illness with an inevitably complex treatment. Methods: This article summarizes the current status of our knowledge and practice of its treatment. Results: It is widely accepted that lithium is moderately useful during all phases of bipolar illness and it might possess a specific effectiveness on suicidal prevention. Both first and second generation antipsychotics are widely used and the FDA has approved olanzapine, risperidone, quetiapine, ziprasidone and aripiprazole for the treatment of acute mania. These could also be useful in the treatment of bipolar depression, but only limited data exists so far to support the use of quetiapine monotherapy or the olanzapine-fluoxetine combination. Some, but not all, anticonvulsants possess a broad spectrum of effectiveness, including mixed dysphoric and rapid-cycling forms. Lamotrigine may be effective in the treatment of depression but not mania. Antidepressant use is controversial. Guidelines suggest their cautious use in combination with an antimanic agent, because they are supposed to induce switching to mania or hypomania, mixed episodes and rapid cycling. Conclusion: The first-line psychosocial intervention in BD is psychoeducation, followed by cognitive-behavioral therapy. Other treatment options include Electroconvulsive therapy and transcranial magnetic stimulation. There is a gap between the evidence base, which comes mostly from monotherapy trials, and clinical practice, where complex treatment regimens are the rule.
publishDate 2007
dc.date.none.fl_str_mv 2007
2009
2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/7306
url https://hdl.handle.net/2445/7306
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a http://dx.doi.org/10.1186/1744-859X-6-27
Annals of General Psychiatry, 2007, vol. 6, núm. 27
http://dx.doi.org/10.1186/1744-859X-6-27
dc.rights.none.fl_str_mv cc-by, (c) Fountoulakis et al., 2007
http://creativecommons.org/licenses/by/2.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by, (c) Fountoulakis et al., 2007
http://creativecommons.org/licenses/by/2.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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