Severe COVID-19 pneumonia in Piacenza, Italy – a cohort study of the first pandemic wave

[Background] Piacenza is the closest city to the first coronavirus disease 2019 (COVID-19) cluster in Italy and has the highest national COVID-19 death rates per population. The objective of this study is to present characteristics and outcomes of patients admitted to medical departments of the Hosp...

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Autores: Guglielmetti, Lorenzo, Kontsevaya, Irina, Leoni, Maria Cristina, Ferrante, Patrizia, Fronti, Elisa, Gerna, Laura, Valdatta, Caterina, Donisi, Alessandra, Faggi, Alberto, Paolillo, Franco, Ratti, Giovanna, Ruggieri, Alessandro, Scotti, Marta, Sacchini, Daria, Taliani, Gloria, Codeluppi, Mauro
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/226731
Acesso em linha:http://hdl.handle.net/10261/226731
Access Level:acceso abierto
Palavra-chave:SARS-CoV-2
Coronavirus
Viral pneumonia
Acute respiratory distress syndromemortality
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spelling Severe COVID-19 pneumonia in Piacenza, Italy – a cohort study of the first pandemic waveGuglielmetti, LorenzoKontsevaya, IrinaLeoni, Maria CristinaFerrante, PatriziaFronti, ElisaGerna, LauraValdatta, CaterinaDonisi, AlessandraFaggi, AlbertoPaolillo, FrancoRatti, GiovannaRuggieri, AlessandroScotti, MartaSacchini, DariaTaliani, GloriaCodeluppi, MauroSARS-CoV-2CoronavirusViral pneumoniaAcute respiratory distress syndromemortality[Background] Piacenza is the closest city to the first coronavirus disease 2019 (COVID-19) cluster in Italy and has the highest national COVID-19 death rates per population. The objective of this study is to present characteristics and outcomes of patients admitted to medical departments of the Hospital of Piacenza during the first wave of the epidemic.[Methods] A total of 218 patients with confirmed or suspect COVID-19 and severe pneumonia were included from February 21st to May 15th, 2020. Routinely-collected clinical and laboratory data were retrospectively retrieved from electronic medical files. A Cox proportional-hazards model was fit to assess the association of treatment and other variables with death.[Results] Median age of patients was 68 years; 150 patients (69%) had comorbidities, mainly hypertension (107, 49%). Overall, 185 (85%) patients had acute respiratory distress syndrome (ARDS) on admission, including 103 (47%) with moderate or severe ARDS. Chest computed tomography scan showed bilateral disease in 201 (98%) and extensive lung involvement in 79 (50%) patients. Most patients received antiviral treatment (187, 86%) and corticosteroids (134, 61%). All patients received respiratory support and 64 (29%) were admitted to intensive care unit. As of June 30th, 100 patients (46%) died, 109 patients (50%) were discharged, and 9 patients (4%) were still hospitalized. In multivariable Cox analysis, age above 65 years, having more than one comorbidity, severe ARDS, low platelet counts, and high LDH levels at admission were associated with mortality, while having diarrhea at admission was associated with survival. The use of antivirals or corticosteroids was not associated with survival.[Conclusions] Overall case fatality rates were high and associated with comorbidities, extensive lung involvement, ARDS at admission, and advanced age. The use of antivirals was not associated with increased survival.Peer reviewedElsevier BVGuglielmetti, Lorenzo [0000-0003-0886-9635]Kontsevaya, Irina [0000-0003-3421-7550]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/226731reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.jiph.2020.11.012Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2267312026-05-22T06:33:51Z
dc.title.none.fl_str_mv Severe COVID-19 pneumonia in Piacenza, Italy – a cohort study of the first pandemic wave
title Severe COVID-19 pneumonia in Piacenza, Italy – a cohort study of the first pandemic wave
spellingShingle Severe COVID-19 pneumonia in Piacenza, Italy – a cohort study of the first pandemic wave
Guglielmetti, Lorenzo
SARS-CoV-2
Coronavirus
Viral pneumonia
Acute respiratory distress syndromemortality
title_short Severe COVID-19 pneumonia in Piacenza, Italy – a cohort study of the first pandemic wave
title_full Severe COVID-19 pneumonia in Piacenza, Italy – a cohort study of the first pandemic wave
title_fullStr Severe COVID-19 pneumonia in Piacenza, Italy – a cohort study of the first pandemic wave
title_full_unstemmed Severe COVID-19 pneumonia in Piacenza, Italy – a cohort study of the first pandemic wave
title_sort Severe COVID-19 pneumonia in Piacenza, Italy – a cohort study of the first pandemic wave
dc.creator.none.fl_str_mv Guglielmetti, Lorenzo
Kontsevaya, Irina
Leoni, Maria Cristina
Ferrante, Patrizia
Fronti, Elisa
Gerna, Laura
Valdatta, Caterina
Donisi, Alessandra
Faggi, Alberto
Paolillo, Franco
Ratti, Giovanna
Ruggieri, Alessandro
Scotti, Marta
Sacchini, Daria
Taliani, Gloria
Codeluppi, Mauro
author Guglielmetti, Lorenzo
author_facet Guglielmetti, Lorenzo
Kontsevaya, Irina
Leoni, Maria Cristina
Ferrante, Patrizia
Fronti, Elisa
Gerna, Laura
Valdatta, Caterina
Donisi, Alessandra
Faggi, Alberto
Paolillo, Franco
Ratti, Giovanna
Ruggieri, Alessandro
Scotti, Marta
Sacchini, Daria
Taliani, Gloria
Codeluppi, Mauro
author_role author
author2 Kontsevaya, Irina
Leoni, Maria Cristina
Ferrante, Patrizia
Fronti, Elisa
Gerna, Laura
Valdatta, Caterina
Donisi, Alessandra
Faggi, Alberto
Paolillo, Franco
Ratti, Giovanna
Ruggieri, Alessandro
Scotti, Marta
Sacchini, Daria
Taliani, Gloria
Codeluppi, Mauro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Guglielmetti, Lorenzo [0000-0003-0886-9635]
Kontsevaya, Irina [0000-0003-3421-7550]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv SARS-CoV-2
Coronavirus
Viral pneumonia
Acute respiratory distress syndromemortality
topic SARS-CoV-2
Coronavirus
Viral pneumonia
Acute respiratory distress syndromemortality
description [Background] Piacenza is the closest city to the first coronavirus disease 2019 (COVID-19) cluster in Italy and has the highest national COVID-19 death rates per population. The objective of this study is to present characteristics and outcomes of patients admitted to medical departments of the Hospital of Piacenza during the first wave of the epidemic.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/226731
url http://hdl.handle.net/10261/226731
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.jiph.2020.11.012
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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