Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers

Producción Científica

Detalles Bibliográficos
Autores: Fernández Colino, Alicia, Wolf, Frederic, Moreira, Ricardo, Rütten, Stephan, Schmitz-Rode, Thomas, Rodríguez Cabello, José Carlos, Jockenhoevel, Stefan, Mela, Petra
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2019
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/40371
Acceso en línea:https://doi.org/10.1016/j.eurpolymj.2019.109334
http://uvadoc.uva.es/handle/10324/40371
Access Level:acceso abierto
Palabra clave:Coronary stents
Stents coronarios
Elastin-like recombinamers
Recombinantes tipo elastina
Click chemistry
Química click
Hemocompatibility
Hemocompatibilidad
id ES_fd7db6df65166bcb8d9b1245ba588b61
oai_identifier_str oai:uvadoc.uva.es:10324/40371
network_acronym_str ES
network_name_str España
repository_id_str
spelling Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamersFernández Colino, AliciaWolf, FredericMoreira, RicardoRütten, StephanSchmitz-Rode, ThomasRodríguez Cabello, José CarlosJockenhoevel, StefanMela, PetraCoronary stentsStents coronariosElastin-like recombinamersRecombinantes tipo elastinaClick chemistryQuímica clickHemocompatibilityHemocompatibilidadProducción CientíficaCoronary artery disease is the leading cause of death around the world. Endovascular stenting is the preferred treatment option to restore blood flow in the coronary arteries due to the lower perioperative morbidity when compared with more invasive treatment options. However, stent failure is still a major clinical problem, and further technological solutions are required to improve the performance of current stents. Here, we developed coronary stents covered with elastin-like recombinamers (ELRs) by exploiting a layer-by-layer technique combined with catalyst-free click chemistry. The resulting ELR-covered stents were intact after an in vitro simulated implantation procedure by balloon dilatation, which evidenced the elastic performance of the membrane. Additionally, the stents were mechanically stable under high flow conditions, which is in agreement with the covalent and stable nature of the click chemistry crosslinking strategy exploited during the ELR-membrane manufacturing and the successful embedding of the stent. Minimal platelet adhesion was detected after blood exposure in a Chandler loop as shown by scanning electron microscopy. The seeding of human endothelial progenitor cells (EPCs) on the ELR-membranes resulted in a confluent endothelial layer. These results prove the potential of this strategy to develop an advanced generation of coronary stents, with a stable and bioactive elastin-like membrane to exclude the atherosclerotic plaque from the blood stream or to seal coronary perforations and aneurysms, while providing a luminal surface with minimal platelet adhesion and favouring endothelialization.German federal and state governments (project StUpPD_330-18)Ministerio de Economía, Industria y Competitividad (projects PCIN-2015-010 / MAT2016-78903-R)Junta de Castilla y León (project VA317P18)Elsevier2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionapplication/pdfhttps://doi.org/10.1016/j.eurpolymj.2019.109334http://uvadoc.uva.es/handle/10324/40371reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.sciencedirect.com/science/article/pii/S0014305719313035info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/403712026-06-13T12:44:47Z
dc.title.none.fl_str_mv Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers
title Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers
spellingShingle Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers
Fernández Colino, Alicia
Coronary stents
Stents coronarios
Elastin-like recombinamers
Recombinantes tipo elastina
Click chemistry
Química click
Hemocompatibility
Hemocompatibilidad
title_short Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers
title_full Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers
title_fullStr Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers
title_full_unstemmed Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers
title_sort Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers
dc.creator.none.fl_str_mv Fernández Colino, Alicia
Wolf, Frederic
Moreira, Ricardo
Rütten, Stephan
Schmitz-Rode, Thomas
Rodríguez Cabello, José Carlos
Jockenhoevel, Stefan
Mela, Petra
author Fernández Colino, Alicia
author_facet Fernández Colino, Alicia
Wolf, Frederic
Moreira, Ricardo
Rütten, Stephan
Schmitz-Rode, Thomas
Rodríguez Cabello, José Carlos
Jockenhoevel, Stefan
Mela, Petra
author_role author
author2 Wolf, Frederic
Moreira, Ricardo
Rütten, Stephan
Schmitz-Rode, Thomas
Rodríguez Cabello, José Carlos
Jockenhoevel, Stefan
Mela, Petra
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Coronary stents
Stents coronarios
Elastin-like recombinamers
Recombinantes tipo elastina
Click chemistry
Química click
Hemocompatibility
Hemocompatibilidad
topic Coronary stents
Stents coronarios
Elastin-like recombinamers
Recombinantes tipo elastina
Click chemistry
Química click
Hemocompatibility
Hemocompatibilidad
description Producción Científica
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.eurpolymj.2019.109334
http://uvadoc.uva.es/handle/10324/40371
url https://doi.org/10.1016/j.eurpolymj.2019.109334
http://uvadoc.uva.es/handle/10324/40371
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0014305719313035
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425544819376128
score 15,300719

Similares en LA Referencia