Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity

Pujante, P. (P.)|||/items/ce6ab1ac-0af8-456e-a071-70c97d8fd195; Abreu, C. (Cristina)|||/items/de111e9f-c5b5-4f80-8990-abc6b3ee712f; Moreno-Arribas, J. (José)|||/items/7617cda1-9964-4d8b-b9c4-209b1ac7ed65; Barrero-Alegria, E. (Eduardo)|||/items/6fb45860-a4be-4dcf-9227-f3de66547637; Azcarate, P.M. (Pedro María)|||/items/4bb480b2-102f-4072-bdb0-eac8fc9953ea; Campo, A. (Arantza)|||/items/815c51d2-2d5b-42a8-a048-4679199d5367; Urrestarazu-Bolumburu, E. (Elena)|||/items/be7fd807-8726-4879-9e1e-3cf201af34f2; Silva-Frojan, C. (Camilo)|||/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef; Gil-Maria, J. (Jesús)|||/items/cc9bc51c-44e3-49ca-befd-76689ca17f4e; Tebar, J. (Javier)|||/items/adedfd12-2a06-45db-b370-dd936509463c; Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b; Salvador-Rodríguez, F.J. (Francisco Javier)|||/items/1175815b-412b-41a6-b91f-6dbfa349f9c8

Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity

OBJECTIVE: To evaluate the relation between obstructive sleep apnea (OSA) and left ventricular mass (LVM) in morbid obesity and the influence of gender, menopausal status, anthropometry, body composition, hypertension, and other cardiovascular risk factors in this relationship. DESIGN: Cross-section...

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Autores:	Pujante, P. (P.)\|\|\|/items/ce6ab1ac-0af8-456e-a071-70c97d8fd195, Abreu, C. (Cristina)\|\|\|/items/de111e9f-c5b5-4f80-8990-abc6b3ee712f, Moreno-Arribas, J. (José)\|\|\|/items/7617cda1-9964-4d8b-b9c4-209b1ac7ed65, Barrero-Alegria, E. (Eduardo)\|\|\|/items/6fb45860-a4be-4dcf-9227-f3de66547637, Azcarate, P.M. (Pedro María)\|\|\|/items/4bb480b2-102f-4072-bdb0-eac8fc9953ea, Campo, A. (Arantza)\|\|\|/items/815c51d2-2d5b-42a8-a048-4679199d5367, Urrestarazu-Bolumburu, E. (Elena)\|\|\|/items/be7fd807-8726-4879-9e1e-3cf201af34f2, Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef, Gil-Maria, J. (Jesús)\|\|\|/items/cc9bc51c-44e3-49ca-befd-76689ca17f4e, Tebar, J. (Javier)\|\|\|/items/adedfd12-2a06-45db-b370-dd936509463c, Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b, Salvador-Rodríguez, F.J. (Francisco Javier)\|\|\|/items/1175815b-412b-41a6-b91f-6dbfa349f9c8
Tipo de recurso:	artículo
Fecha de publicación:	2013
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/36333
Acceso en línea:	https://hdl.handle.net/10171/36333
Access Level:	acceso abierto
Palabra clave:	Sleep apnea Apnea-hypopnea index Left ventricular mass Morbid obesity Neurofisiología Bioquímica clínica

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spelling	Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesityPujante, P. (P.)\|\|\|/items/ce6ab1ac-0af8-456e-a071-70c97d8fd195Abreu, C. (Cristina)\|\|\|/items/de111e9f-c5b5-4f80-8990-abc6b3ee712fMoreno-Arribas, J. (José)\|\|\|/items/7617cda1-9964-4d8b-b9c4-209b1ac7ed65Barrero-Alegria, E. (Eduardo)\|\|\|/items/6fb45860-a4be-4dcf-9227-f3de66547637Azcarate, P.M. (Pedro María)\|\|\|/items/4bb480b2-102f-4072-bdb0-eac8fc9953eaCampo, A. (Arantza)\|\|\|/items/815c51d2-2d5b-42a8-a048-4679199d5367Urrestarazu-Bolumburu, E. (Elena)\|\|\|/items/be7fd807-8726-4879-9e1e-3cf201af34f2Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465efGil-Maria, J. (Jesús)\|\|\|/items/cc9bc51c-44e3-49ca-befd-76689ca17f4eTebar, J. (Javier)\|\|\|/items/adedfd12-2a06-45db-b370-dd936509463cFrühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663bSalvador-Rodríguez, F.J. (Francisco Javier)\|\|\|/items/1175815b-412b-41a6-b91f-6dbfa349f9c8Sleep apneaApnea-hypopnea indexLeft ventricular massMorbid obesityNeurofisiologíaBioquímica clínicaOBJECTIVE: To evaluate the relation between obstructive sleep apnea (OSA) and left ventricular mass (LVM) in morbid obesity and the influence of gender, menopausal status, anthropometry, body composition, hypertension, and other cardiovascular risk factors in this relationship. DESIGN: Cross-sectional descriptive study. METHODS: Polysomnographic and echocardiographic studies were performed in a cohort of 242 patients (86 men, 100 premenopausal (PreM) and 56 postmenopausal (PostM) women), with grade II obesity and above (BMI: 43.7 ± 0.4 kg/m(2)) to investigate OSA and LVM respectively. Anthropometry, body composition, glucose tolerance, and blood pressure were also recorded. RESULTS: OSA to different degrees was diagnosed in 76.2% of the patients (n: 166), its prevalence being 90.9% (n: 70) for men, and 76% (n: 38) and 63.8% (n: 58) for PostM and PreM women, respectively (p < 0.01). LVM excess was greatest for PostM women (90.2%), followed by men (81.9%) and PreM females (69.6%) (p < 0.01). LVM values increased in accordance to OSA severity (absence, 193.7 ± 6.9 g; mild, 192.6 ± 7.8 g; moderate, 240.5 ± 12.5 g; severe, 273.6 ± 14.6 g; p < 0.01). LVM magnitude correlated with the menopausal state, age, central adiposity, hypertension (HT), type 2 diabetes (DM), desaturation index (DI), and apnea-hypopnea index (AHI) (r = 0.41; p < 0.01). The relationship between LVM and AHI persisted in the multivariate analysis (β = 0.25; p < 0.05) after adjusting for age, gender, menopausal state, BMI, waist circumference, neck circumference, DI, fasting plasma glucose, DM, and HT. But if tobacco habits are included, the statistical difference disappears (β = 0.22; p = 0.06). CONCLUSIONS: Morbid obesity is frequently associated with abnormal LVM, particularly in patients with OSA; this association is independent of HT, BMI, body composition, and other clinical factors, supporting a direct role of OSA on LVM in morbid obesity. This suggests that OSA and LVM might be taken as predictors of the cardiovascular risk in these patients. KEYWORDS: Sleep apnea; apnea-hypopnea index; left ventricular mass; morbid obesityAmerican Academy of Sleep MedicineDadun. Depósito Académico Digital Universidad de Navarra20142014-08-1920132013-01-0120132013-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/36333reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/363332026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity
title	Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity
spellingShingle	Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity Pujante, P. (P.)\|\|\|/items/ce6ab1ac-0af8-456e-a071-70c97d8fd195 Sleep apnea Apnea-hypopnea index Left ventricular mass Morbid obesity Neurofisiología Bioquímica clínica
title_short	Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity
title_full	Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity
title_fullStr	Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity
title_full_unstemmed	Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity
title_sort	Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity
dc.creator.none.fl_str_mv	Pujante, P. (P.)\|\|\|/items/ce6ab1ac-0af8-456e-a071-70c97d8fd195 Abreu, C. (Cristina)\|\|\|/items/de111e9f-c5b5-4f80-8990-abc6b3ee712f Moreno-Arribas, J. (José)\|\|\|/items/7617cda1-9964-4d8b-b9c4-209b1ac7ed65 Barrero-Alegria, E. (Eduardo)\|\|\|/items/6fb45860-a4be-4dcf-9227-f3de66547637 Azcarate, P.M. (Pedro María)\|\|\|/items/4bb480b2-102f-4072-bdb0-eac8fc9953ea Campo, A. (Arantza)\|\|\|/items/815c51d2-2d5b-42a8-a048-4679199d5367 Urrestarazu-Bolumburu, E. (Elena)\|\|\|/items/be7fd807-8726-4879-9e1e-3cf201af34f2 Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef Gil-Maria, J. (Jesús)\|\|\|/items/cc9bc51c-44e3-49ca-befd-76689ca17f4e Tebar, J. (Javier)\|\|\|/items/adedfd12-2a06-45db-b370-dd936509463c Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Salvador-Rodríguez, F.J. (Francisco Javier)\|\|\|/items/1175815b-412b-41a6-b91f-6dbfa349f9c8
author	Pujante, P. (P.)\|\|\|/items/ce6ab1ac-0af8-456e-a071-70c97d8fd195
author_facet	Pujante, P. (P.)\|\|\|/items/ce6ab1ac-0af8-456e-a071-70c97d8fd195 Abreu, C. (Cristina)\|\|\|/items/de111e9f-c5b5-4f80-8990-abc6b3ee712f Moreno-Arribas, J. (José)\|\|\|/items/7617cda1-9964-4d8b-b9c4-209b1ac7ed65 Barrero-Alegria, E. (Eduardo)\|\|\|/items/6fb45860-a4be-4dcf-9227-f3de66547637 Azcarate, P.M. (Pedro María)\|\|\|/items/4bb480b2-102f-4072-bdb0-eac8fc9953ea Campo, A. (Arantza)\|\|\|/items/815c51d2-2d5b-42a8-a048-4679199d5367 Urrestarazu-Bolumburu, E. (Elena)\|\|\|/items/be7fd807-8726-4879-9e1e-3cf201af34f2 Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef Gil-Maria, J. (Jesús)\|\|\|/items/cc9bc51c-44e3-49ca-befd-76689ca17f4e Tebar, J. (Javier)\|\|\|/items/adedfd12-2a06-45db-b370-dd936509463c Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Salvador-Rodríguez, F.J. (Francisco Javier)\|\|\|/items/1175815b-412b-41a6-b91f-6dbfa349f9c8
author_role	author
author2	Abreu, C. (Cristina)\|\|\|/items/de111e9f-c5b5-4f80-8990-abc6b3ee712f Moreno-Arribas, J. (José)\|\|\|/items/7617cda1-9964-4d8b-b9c4-209b1ac7ed65 Barrero-Alegria, E. (Eduardo)\|\|\|/items/6fb45860-a4be-4dcf-9227-f3de66547637 Azcarate, P.M. (Pedro María)\|\|\|/items/4bb480b2-102f-4072-bdb0-eac8fc9953ea Campo, A. (Arantza)\|\|\|/items/815c51d2-2d5b-42a8-a048-4679199d5367 Urrestarazu-Bolumburu, E. (Elena)\|\|\|/items/be7fd807-8726-4879-9e1e-3cf201af34f2 Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef Gil-Maria, J. (Jesús)\|\|\|/items/cc9bc51c-44e3-49ca-befd-76689ca17f4e Tebar, J. (Javier)\|\|\|/items/adedfd12-2a06-45db-b370-dd936509463c Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Salvador-Rodríguez, F.J. (Francisco Javier)\|\|\|/items/1175815b-412b-41a6-b91f-6dbfa349f9c8
author2_role	author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Sleep apnea Apnea-hypopnea index Left ventricular mass Morbid obesity Neurofisiología Bioquímica clínica
topic	Sleep apnea Apnea-hypopnea index Left ventricular mass Morbid obesity Neurofisiología Bioquímica clínica
description	OBJECTIVE: To evaluate the relation between obstructive sleep apnea (OSA) and left ventricular mass (LVM) in morbid obesity and the influence of gender, menopausal status, anthropometry, body composition, hypertension, and other cardiovascular risk factors in this relationship. DESIGN: Cross-sectional descriptive study. METHODS: Polysomnographic and echocardiographic studies were performed in a cohort of 242 patients (86 men, 100 premenopausal (PreM) and 56 postmenopausal (PostM) women), with grade II obesity and above (BMI: 43.7 ± 0.4 kg/m(2)) to investigate OSA and LVM respectively. Anthropometry, body composition, glucose tolerance, and blood pressure were also recorded. RESULTS: OSA to different degrees was diagnosed in 76.2% of the patients (n: 166), its prevalence being 90.9% (n: 70) for men, and 76% (n: 38) and 63.8% (n: 58) for PostM and PreM women, respectively (p < 0.01). LVM excess was greatest for PostM women (90.2%), followed by men (81.9%) and PreM females (69.6%) (p < 0.01). LVM values increased in accordance to OSA severity (absence, 193.7 ± 6.9 g; mild, 192.6 ± 7.8 g; moderate, 240.5 ± 12.5 g; severe, 273.6 ± 14.6 g; p < 0.01). LVM magnitude correlated with the menopausal state, age, central adiposity, hypertension (HT), type 2 diabetes (DM), desaturation index (DI), and apnea-hypopnea index (AHI) (r = 0.41; p < 0.01). The relationship between LVM and AHI persisted in the multivariate analysis (β = 0.25; p < 0.05) after adjusting for age, gender, menopausal state, BMI, waist circumference, neck circumference, DI, fasting plasma glucose, DM, and HT. But if tobacco habits are included, the statistical difference disappears (β = 0.22; p = 0.06). CONCLUSIONS: Morbid obesity is frequently associated with abnormal LVM, particularly in patients with OSA; this association is independent of HT, BMI, body composition, and other clinical factors, supporting a direct role of OSA on LVM in morbid obesity. This suggests that OSA and LVM might be taken as predictors of the cardiovascular risk in these patients. KEYWORDS: Sleep apnea; apnea-hypopnea index; left ventricular mass; morbid obesity
publishDate	2013
dc.date.none.fl_str_mv	2013 2013-01-01 2013 2013-01-01 2014 2014-08-19
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/36333
url	https://hdl.handle.net/10171/36333
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	American Academy of Sleep Medicine
publisher.none.fl_str_mv	American Academy of Sleep Medicine
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Obstructive sleep apnea severity is associated with left ventricular mass independent of other cardiovascular risk factors in morbid obesity

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